It is widely acknowledged that compliance and persistence with oral osteoporosis medications, particularly with bisphosphonates, is poor. Several excellent reviews have been written on compliance and persistence with osteoporosis medications and have discussed improvements seen with extended dosing intervals. This review begins with studies on extended dosing intervals to examine the limitations of administrative claims data. It also looks at compliance and persistence across multiple medical conditions, examining the importance of prescription fulfillment, intentional choice, causation and possible interventions.
Granger BB, Swedberg K, Ekman I, et al. Adherence to candesartan and placebo and outcomes in chronic renal failure in the CHARM program, double-blind randomized controlled trial. Lancet. 2005;366:2005–11. CrossRef
Curtis J, Larson J, Delzell E, Judd S, Safford MM, LaCroix A, et al. Does the benefit of medication adherence relate more to a drug effect or the behavior Itself? Quantifying the effect of adherence behavior using data from the placebo arms of the WHI. [abstract]. Arthritis Rheum. 2009;60 Suppl 10:613. doi: 10.1002/art.25693.
Silverman SL, Cramer JA, Sunyecz JA, et al (2007) Women are more persistent with monthly bisphosphonate therapy compared to weekly bisphosphonates: 12 month results from two retrospective databases. Presented at ASBMR Montreal Sept 19, 2007. Abstract W366.
Griswold ME, Localio AR, Mulrow C. Propensity score adjustment with multilevel data: setting your sites on decreasing selection bias. Ann Int Med. 2010;152:393–5. PubMed
Hamilton B, McCoy K, Taggart H. Tolerability and compliance with risedronate in clinical practice. Osteoporos Int. 2003;14:259–62.
Kennedy J, Teleu I, Mackay K. Unfilled prescriptions of Medicare beneficiaries: prevalence, reasons, and types of medicines prescribed. J Manage Care Pharm. 2008;14:553–60.
Boston Consulting Group (BCG) (2002) Analysis: Harris Interactive 10,000 Patient Survey 2002 at http://www.bcg.com/documents/file14265.pdf accessed October 21,2009.
Rees, G., Leong, O., Crowston, J. C. Intentional and Unintentional Nonadherence to Ocular or Hypertensive Treatment in Patients with Glaucoma, Ophthalmology, 2010, doi: 10.1016/j.ophtha.2009.10.038.
Christensen AJ, Howren MB, Hillis SL, Kaboli P, Carter BL, Cvengros JA, Wallston KA, Rosenthal GE. Patient and physician beliefs about control over health: association of symmetrical beliefs with medication regimen adherence. J Gen Intern Med. 2010;25(5):397–402.
Trinacty CM, Adams AS, Soumerai SB, et al. Racial differences in long term adherence to oral antidiabetic drug theraphy: a longitudinal cohort study. BMC Health Services Research 2009;9:24–34. doi: 10.1186/1472-6963-9-24.
Cramer JA. Systematic review of adherence with medicines for diabetes. Diabetes Care. 2004;2712:18–24.
Zivin K, Ganoczy D, Pfeiffer PN, Miller EM, Valenstein M. Antidepressant adherence after psychiatric hospitalization among VA patients with depression. Admin Pol Ment Health. 2009;36(6):406–15. CrossRef
Cizza G, Primma S, Csako G. Depression as a risk factor for osteoporosis. Trends Endocrinol Metabol. 2009;20(8):367–73. CrossRef
Buist DS, LaCroix AZ, Black DM, Harris F, Blank J, Ensrud K, et al. Inclusion of older women in randomized clinical trials: factors associated with taking study medication in the fracture intervention trial. J Am Geriatr Soc. 2000;48(9):1126–31. PubMed
Bryson CL, Au DH, et al. Alcohol screening scores and medication non-adherence. Ann Intern Med. 2008;149:795–804. PubMed
Thiebaud P, Patel BV, Nichol MB, Berenbeim DM. The effect of switching on compliance and persistence: the case of statin treatment. Am J Manag Care. 2005;11:670–74. PubMed
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008;16(2):CD000011.
Wilson Sr , Stroub P, Buist AS, et al. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med. 2010;181:566–77. CrossRef
- Compliance and persistence with osteoporosis medications: A critical review of the literature
Deborah T. Gold
- Springer US
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