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Journal of Assisted Reproduction and Genetics
Erschienen in: Journal of Assisted Reproduction and Genetics 6/2018

25.04.2018 | Review

Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology

verfasst von: Victoria K. Cortessis, Moosa Azadian, James Buxbaum, Fatimata Sanogo, Ashley Y. Song, Intira Sriprasert, Pengxiao C. Wei, Jing Yu, Karine Chung, Kimberly D. Siegmund

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 6/2018

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Abstract

Purpose

To determine whether a history of conception by assisted reproductive technology (ART) is associated with occurrence of one or more imprinting disorders of either maternal or paternal origin.

Methods

We implemented a systematic review of scholarly literature followed by comprehensive meta-analysis to quantitatively synthesize data from reports relating to use of ART to occurrence of any imprinting disorder of humans, including Beckwith-Wiedemann (BWS), Angelman (AS), Prader-Willi (PWS), and Silver-Russell (SRS) syndromes, as well as transient neonatal diabetes mellitus (TNDB) and sporadic retinoblasoma (RB).

Results

The systematic review identified 13 reports presenting unique data from 23 studies that related conception following ART to occurrence of imprinting disorders. Multiple studies of four disorder were identified, for which meta-analysis yielded the following summary estimates of associations with a history of ART: AS, summary odds ratio (sOR) = 4.7 (95% confidence interval (CI) 2.6–8.5, 4 studies); BWS, sOR = 5.8 (95% CI 3.1–11.1, 8 studies); PWS, sOR = 2.2 (95% CI 1.6–3.0, 6 studies); SRS, sOR = 11.3 (95% CI 4.5–28.5, 3 studies). Only one study reported on each of TNDB and RB.

Conclusion

Published data reveal positive associations between history of ART conception and each of four imprinting disorders. Reasons for these associations warrant further investigation.
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Metadaten
Titel
Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology
verfasst von
Victoria K. Cortessis
Moosa Azadian
James Buxbaum
Fatimata Sanogo
Ashley Y. Song
Intira Sriprasert
Pengxiao C. Wei
Jing Yu
Karine Chung
Kimberly D. Siegmund
Publikationsdatum
25.04.2018
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 6/2018
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-1173-x

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