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19.05.2017 | Special Article | Ausgabe 3/2017 Open Access

Esophagus 3/2017

Comprehensive Registry of Esophageal Cancer in Japan, 2010

Zeitschrift:
Esophagus > Ausgabe 3/2017
Autoren:
Yuji Tachimori, Soji Ozawa, Hodaka Numasaki, Ryu Ishihara, Hisahiro Matsubara, Kei Muro, Tsuneo Oyama, Yasushi Toh, Harushi Udagawa, Takashi Uno, The Registration Committee for Esophageal Cancer of the Japan Esophageal Society
Wichtige Hinweise
These data were first made available on January 2017, as the Comprehensive Registry of Esophageal Cancer in Japan, 2010. Not all the pages are reprinted here.
The authors were members of the Registration Committee for Esophageal Cancer, the Japan Esophageal Society, and made great contributions to the preparation of this material.

Preface 2010

We deeply appreciate the great contributions of many physicians in the registry of esophageal cancer cases. The Comprehensive Registry of Esophageal Cancer in Japan, 2010, was published here, despite some delay. The registry complies with the Act for the Protection of Personal Information. The encryption with a HASH function is used for ‘‘anonymity in an unlinkable fashion’’.
We briefly summarized the Comprehensive Registry of Esophageal Cancer in Japan, 2010. Japanese Classification of Esophageal Cancer 10th and UICC TNM Classification 7th were used for cancer staging according to the subjected year. A total of 5878 cases were registered from 280 institutions in Japan. Tumor locations were cervical: 4.3%, upper thoracic: 12.7%, middle thoracic: 48.8%, lower thoracic: 26.5% and EG junction: 6.5%. Superficial carcinomas (Tis, T1a, T1b) were 34.9%. As for the histologic type of biopsy specimens, squamous cell carcinoma and adenocarcinoma accounted for 90.5 and 4.0%, respectively. Regarding clinical results, the 5-year survival rates of patients treated using endoscopic mucosal resection, concurrent chemoradiotherapy, or esophagectomy were 85.5, 27.3, and 55.5%, respectively. Esophagectomy was performed in 3564 cases. Concerning the approach used for esophagectomy, 30.4% of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.61% and the hospital mortality was 4.29%.
We hope that this Comprehensive Registry of Esophageal Cancer in Japan for 2010 will help to improve all aspects of the diagnosis and treatment of esophageal cancer in Japan.

Contents

I.
I. Clinical factors of esophageal cancer patients treated in 2010
1.
Institution-registered cases in 2010
 
2.
Patient background
  • Table 1 Age and gender
  • Table 2 Primary treatment
  • Table 3 Tumor location
  • Table 4 Histologic types of biopsy specimens
  • Table 5 Depth of tumor invasion, cT (UICC TNM 7th)
  • Table 6 Lymph node metastasis, cN (UICC TNM 7th)
  • Table 7 Distant metastasis, cM (UICC TNM 7th)
  • Table 8 Clinical Stage (UICC TNM 7th)
 
 
II.
Results of endoscopically treated patients in 2010
  • Table 9 Details of endoscopic treatment
  • Table 10 Complications of EMR/ESD
  • Table 11 Pathological depth of tumor invasion of EMR/ESD specimens
  • Figure 1 Survival of patients treated with EMR/ESD
  • Figure 2 Survival of patients treated with EMR/ESD according to the pathological depth of tumor invasion (pT)
  • Figure 3 Survival of patients treated with EMR/ESD according to the lymphatic and venous invasion
 
III.
Results in patients treated with chemotherapy and/or radiotherapy in 2010
  • Table 12 Dose of irradiation (non-surgically treated cases)
  • Table 13 Dose of irradiation (surgically treated cases)
  • Figure 4 Survival of patients treated with chemotherapy and/or radiotherapy
  • Figure 5 Survival of patients treated with definitive chemoradiotherapy according to clinical stage (UICC TNM 7th)
 
IV.
Results in patients who underwent esophagectomy in 2010
  • Table 14 Treatment modalities of esophagectomy
  • Table 15 Tumor location
  • Table 16 Approaches to tumor resection
  • Table 17 Video-assisted surgery
  • Table 18 Fields of lymph node dissection according to the location of the tumor
  • Table 19 Reconstruction route
  • Table 20 Organs used for reconstruction
  • Table 21 Histological classification
  • Table 22 Depth of tumor invasion, pT (JES 10th)
  • Table 23 Pathological grading of lymph node metastasis, pN (JES 10th)
  • Table 24 Pathological findings of lymph node metastasis, pN (UICC 7th)
  • Table 25 Pathological findings of distant organ metastasis, pM (JES 10th)
  • Table 26 Residual tumor
  • Table 27 Causes of death
  • Figure 6 Survival of patients who underwent esophagectomy
  • Figure 7 Survival of patients who underwent esophagectomy according to clinical stage (JES 10th)
  • Figure 8 Survival of patients who underwent esophagectomy according to clinical stage (UICC 7th)
  • Figure 9 Survival of patients who underwent esophagectomy according to the depth of tumor invasion, pT (JES 10th)
  • Figure 10 Survival of patients who underwent esophagectomy according to lymph node metastasis, pN (JES 10th)
  • Figure 11 Survival of patients who underwent esophagectomy according to lymph node metastasis, pN (UICC 7th)
  • Figure 12 Survival of patients who underwent esophagectomy according to pathological stage (JES 10th)
  • Figure 13 Survival of patients who underwent esophagectomy according to pathological stage (UICC TNM 7th)
  • Figure 14 Survival of patients who underwent esophagectomy according to residual tumor (R)
 

I. Clinical factors of esophageal cancer patients treated in 2010

Institution-registered cases in 2010

Institution
Aichi Cancer Center
Aichi Medical University Hospital
Aizawa Hospital
Akita Kouseiren Hiraka Hospital
Akita University Hospital
Arao Municipal Hospital
Asahikawa Medical College Hospital
Chiba Aoba Municipal Hospital
Chiba Cancer Center
Chiba Medical Center
Chiba Prefectural Sawara Hospital
Chiba University Hospital
Chibaken Saiseikai Narashino Hospital
Dokkyo Medical University Hospital
Ehime University Hospital
Foundation for Detection of Early Gastric Carcinoma
Fuchu Hospital
Fujioka General Hospital
Fujisawa Shounandai Hospital
Fujita Health University
Fukui Prefectural Hospital
Fukui University Hospital
Fukuoka Dental College and Dental Hospital
Fukuoka Saiseikai General Hospital
Fukuoka University Chikushi Hospital
Fukuoka University Hospital
Fukuoka Wajiro Hospital
Fukushima Medical University Hospital
Fukuyama City Hospital
Fussa Hospital
Gifu Prefectural General Medical Center
Gifu University Hospital
Gunma Central General Hospital
Gunma Prefectural Cancer Center
Gunma University Hospital
Gunmaken Saiseikai Maebashi Hospital
Hachinohe City Hospital
Hakodate Goryokaku Hospital
Hakodate National Hospital
Hamamatsu University School of Medicine, University Hospital
Hannan Chuo Hospital
Heartlife Hospital
Higashiosaka City General Hospital
Hiratsuka City Hospital
Hiratsuka Kyosai Hospital
Hirosaki University Hospital
Hiroshima City Asa Hospital
Hiroshima University Research Institute for Radiation Biology Medicine
Hofu Institute of Gastroenterology
Hokkaido Kin-Ikyo Chuo Hospital
Hokkaido University Hospital
Hyogo Cancer Center
Hyogo College of Medicine
Hyogo Prefectural Nishinomiya Hospital
Ibaraki Prefectural Central Hospital
Iizuka Hospital
Ikeda Municipal Hospital
Imazu Surgical Clinic
Inazawa City Hospital
International University of Health and Welfare Hospital
International University of Health and Welfare, Mita Hospital
Isehara Kyodo Hospital
Ishikawa Prefectural Central Hospital
Iwakuni Medical Center
Iwate Medical University Hospital
Iwate Prefectural Chubu Hospital
Japanese Red Cross Fukui Hospital
Japanese Red Cross Ishinomaki Hospital
Japanese Red Cross Kyoto Daini Hospital?
Japanese Red Cross Maebashi Hospital
Japanese Red Cross Nagaoka Hospital
Japanese Red Cross Okayama Hospital
Japanese Red Cross Society Azumino Hospital
Japanese Red Cross Tottori Hospital
Jichi Medical University Hospital
Juntendo University Hospital
Juntendo University Shizuoka Hospital
Junwakai Memorial Hospital
Kagawa Prefectural Central Hospital
Kagawa Rosai Hospital
Kagawa University Hospital
Kagoshima Kenritsu Satsunan Hospital
Kagoshima University Hospital
Kameda General Hospital
Kanagawa Cancer Center
Kanazawa Medical University Hospital
Kanazawa University Hospital
Kansai Medical University Hirakata Hospital
Kansai Medical University Medical Center
Kansai Rosai Hospital
Kasamatsu Hospital
Kashiwa Kousei General Hospital
Kawakita General Hospital
Kawasaki Medical School Hospital
Kawasaki Medical School Kawasaki Hospital
Kawasaki Municipal Ida Hospital
Keio University Hospital
Keiyukai Sapporo Hospital
Kikuna Memorial Hospital
Kinki Central Hospital
Kinki University Hospital
Kiryu Kosei General Hospital
Kishiwada City Hospital
Kitaakita Municipal Hospital
Kitakyushu Municipal Medical Center
Kitano Hospital
Kobe City Medical Center General Hospital
Kobe University Hospital
Kochi Health Science Center
Kochi University Hospital
Kokura Memorial Hospital
Kumamoto City Hospital
Kumamoto University Hospital
Kurashiki Central Hospital
Kurume General Hospital
Kurume University Hospital
Kyoto University Hospital
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
Kyushu Hospital
Kyushu Medical Center
Kyushu University Hospital
Machida Municipal Hospital
Matsuda Hospital
Matsushita Memorial Hospital
Matsuyama Red Cross Hospital
Mie University Hospital
Mino City Hospital
Mito Red Cross Hospital
Mitsui Memorial Hospital
Miyazaki Konan Hospital
Murakami General Hospital
Musashino Red Cross Hospital
Nagahama City Hospital
Nagano Red Cross Hospital
Nagaoka Chuo General Hospital
Nagasaki University Hospital
Nagayoshi General Hospital
Nagoya City University Hospital
Nagoya City West Medical Center
Nagoya Daiichi Red Cross Hospital
Nagoya University Hospital
Nanpuh Hospital
Nara Hospital Kinki University Faculty of Medicine
Nara Medical University Hospital
National Cancer Center Hospital
National Cancer Center Hospital East
National Defense Medical College Hospital
National Hospital Organization Beppu Medical Center
National Hospital Organization Chiba-East-Hospital
National Hospital Organization Fukuoka-Higashi Medical Center
National Hospital Organization Iwakuni Medical Center
National Hospital Organization Kure Medical Center
National Hospital Organization Kyoto Medical Center
National Hospital Organization Kyushu Cancer Center
National Hospital Organization Matsumoto National Hospital
National Hospital Organization Nagasaki Medical Center
National Hospital Organization Nagoya Medical Center
National Hospital Organization Osaka National Hospital
National Hospital Organization Tokyo Medical Center
Niigata Cancer Center Hospital
Niigata City General Hospital
Niigata Prefectural Shibata Hospital
Niigata University Medical and Dental Hospital
Nikko Memorial Hospital
Nippon Medical School Chiba Hokusoh Hospital
Nippon Medical School Hospital
Nippon Medical School Musashi Kosugi Hospital
Nippon Medical School Tama Nagayama Hospital
Nishi-Kobe Medical Center
Nishinomiya Municipal Central Hospital
Numazu City Hospital
Obihiro Kousei General Hospital
Obitsusankei Hospital
Ohta General Hospital Foundation Ohta Nishinouchi Hospital
Oita Red Cross Hospital
Oita University Hospital
Okayama Saiseikai General Hospital
Okayama University Hospital
Omuta City Hospital
Osaka City University Hospital
Osaka Hospital of Japan Seafarers Relief Association
Osaka Medical Center for Cancer and Cardiovascular Diseases
Osaka Medical College Hospital
Osaka Police Hospital
Osaka Prefectural Hospital Organization Osaka General Medical Center
Osaka University Hospital
Otsu Municipal Hospital
Otsu Red Cross Hospital
Rinku General Medical Center
Ryukyu University Hospital
Saga-ken Medical Center Koseikan
Saiseikai Fukushima General Hospital
Saiseikai Hiroshima Hospital
Saiseikai Kyoto Hospital
Saiseikai Yahata General Hospital
Saitama Cancer Center
Saitama City Hospital
Saitama Medical Center
Saitama Medical University Hospital
Saitama Medical University Saitama International Medical Center
Saitama Medical University Saitama Medical Center
Sakai City Medical Center
Saku Central Hospital
Sanin Rosai Hospital
Sano Kousei General Hospital
Sendai City Hospital
Sendai Medical Center
Shiga Medical Center for Adults
Shiga University of Medical Science Hospital
Shikoku Cancer Center
Shimada Hospital
Shimane University Hospital
Shimizu Welfare Hospital
Shinshu University Hospital
Shizuoka Cancer Center
Shizuoka City Shizuoka Hospital
Shizuoka General Hospital
Showa University Fujigaoka Hospital
Showa University Hospital
Showa University Koto-Toyosu Hospital
Showa University Northern Yokohama Hospital
Social Insurance Omuta Tenryo Hospital
Social Insurance Tagawa Hospital
St. Marianna University School of Medical Hospital
St. Luke’s International Hospital
Sugita Genpaku Memorial Obama Municipal Hospital
Suita Municipal Hospital
Takasago Municipal Hospital
Takatsuki Red Cross Hospital
Takeda Hospital
Teikyo University Hospital
Teikyo University Hospital, Mizonokuchi
Tenri Hospital
The Cancer Institute Hospital of JFCR
The Jikei University Hospital
The Research Center Hospital for Charged Particle Therapy of NIRS
Tochigi Medical Center
Toho University Omori Medical Center
Toho University Sakura Medical Center
Tohoku Kosai Hospital
Tohoku University Hospital
Tokai University Hospital
Tokushima Municipal Hospital
Tokushima Prefectural Naruto Hospital
Tokushima Red Cross Hospital
Tokushima University Hospital
Tokyo Dental College Ichikawa General Hospital
Tokyo Medical and Dental University Hospital
Tokyo Medical University Hospital
Tokyo Medical University Ibaraki Medical Center
Tokyo Metropolitan Health and Medical Corporation Toshima Hospital
Tokyo University Hospital
Tokyo Women’s Medical University Hospital
Tokyo Women’s Medical University Medical Center East
Tonan Hospital
Toranomon Hospital
Tottori Prefectural Central Hospital
Tottori University Hospital
Toyama Prefectural Central Hospital
Toyama University Hospital
Toyonaka Municipal Hospital
Tsuchiura Kyodo Hospital
Tsukuba University Hospital
Tsuruoka Municipal Shonai Hospital
University Hospital, Kyoto Prefectural University of Medicine
University of Miyazaki Hospital
Wakayama Medical University Hospital
Yamagata Prefectural and Sakata Municipal Hospital Organization
Yamagata Prefectural Central Hospital
Yamagata Prefectural Shinjo Hospital
Yamaguchi University Hospital
Yamaguchi-ken Saiseikai Shimonoseki General Hospital
Yamanashi Prefectural Central Hospital
Yamanashi University Hospital
Yao Municipal Hospital
Yokohama Chuo Hospital
Yokohama City Municipal Hospital
Yokohama City University Hospital
Yokohama City University Medical Center
Yuri General Hospital
(Total 280 institutions)

Patient background

Table 1
Age and gender
Age
Male
Female
Unknown
Cases (%)
≤29
1
1
 
2 (0.0%)
30–39
14
4
 
18 (0.3%)
40–49
125
44
 
169 (2.9%)
50–59
802
145
1
948 (16.1%)
60–69
2140
291
1
2432 (41.4%)
70–79
1596
267
 
1863 (31.7%)
80–89
342
78
 
420 (7.1%)
≥90
8
7
 
15 (0.3%)
Unknown
10
1
 
11 (0.2%)
Total
5038
838
2
5878
Table 2
Primary treatment
Treatments
Cases (%)
Surgery
3638 (61.9%)
 Esophagectomy
3564 (60.6%)
 Palliative
74 (1.3%)
Chemotherapy/radiotherapy
1413 (24.0%)
Endoscopic treatment
827 (14.1%)
Total
5878
Table 3
Tumor location
Location of tumor
Endoscopic treatment (%)
Surgery
Chemotherapy and/or radiotherapy (%)
Total (%)
Esophagectomy (%)
Palliative surgery (%)
Cervical
18 (2.2%)
116 (3.3%)
6 (8.1%)
114 (8.1%)
254 (4.3%)
Upper thoracic
90 (10.9%)
411 (11.5%)
15 (20.3%)
233 (16.5%)
749 (12.7%)
Middle thoracic
483 (58.4%)
1669 (46.8%)
39 (52.7%)
677 (47.9%)
2868 (48.8%)
Lower thoracic
186 (22.5%)
1054 (29.6%)
12 (16.2%)
303 (21.4%)
1555 (26.5%)
EG
34 (4.1%)
241 (6.8%)
1 (1.4%)
31 (2.2%)
307 (5.2%)
E = G
1 (0.1%)
38 (1.1%)
1 (1.4%)
1 (0.1%)
41 (0.7%)
GE
3 (0.4%)
27 (0.8%)
 
6 (0.4%)
36 (0.6%)
Unknown
12 (1.5%)
8 (0.2%)
 
48 (3.4%)
68 (1.2%)
Total
827
3564
74
1413
5878
E esophageal, G gastric
Table 4
Histologic types of biopsy specimens
Histologic types
Cases (%)
Squamous cell carcinoma
5320 (90.5%)
 Squamous cell carcinoma
3581 (60.9%)
 Well differentiated
334 (5.7%)
 Moderately differentiated
1072 (18.2%)
 Poorly differentiated
333 (5.7%)
Adenocarcinoma
233 (4.0%)
Barrett’s adenocarcinoma
64 (1.1%)
Adenosquamous carcinoma
8 (0.1%)
Mucoepidermoid carcinoma
2 (0.0%)
Basaloid carcinoma
27 (0.5%)
Endocrine cell carcinoma
13 (0.2%)
Undifferentiated carcinoma
10 (0.2%)
Sarcoma
2 (0.0%)
Malignant melanoma
16 (0.3%)
Carcinosarcoma
9 (0.2%)
GIST
1 (0.0%)
Other tumors
34 (0.6%)
Unknown
139 (2.4%)
Total
5878
Table 5
Depth of tumor invasion, cT (UICC TNM 7th)
cT
Cases (%)
cTX
16 (0.3%)
cT0
9 (0.2%)
cTis
144 (2.4%)
cT1a
780 (13.3%)
cT1b
1130 (19.2%)
cT2
813 (13.8%)
cT3
2134 (36.3%)
cT4a
357 (6.1%)
cT4b
410 (7.0%)
Unknown
85 (1.4%)
Total
5878
Table 6
Lymph node metastasis, cN (UICC TNM 7th)
cN
Cases (%)
cNX
88 (1.5%)
cN0
2646 (45.0%)
cN1
1642 (27.9%)
cN2
986 (16.8%)
cN3
342 (5.8%)
Unknown
174 (3.0%)
Total
5878
Table 7
Distant metastasis, cM (UICC TNM 7th)
cM
Cases (%)
cM0
5091 (86.6%)
cM1
652 (11.1%)
Unknown
135 (2.3%)
Total
5878
Table 8
Clinical Stage (UICC TNM 7th)
Clinical stage
Endoscopic treatment (%)
Surgery
Chemotherapy and/or radiotherapy (%)
Total (%)
Esophagectomy (%)
Palliative surgery (%)
0
112 (13.5%)
12 (0.3%)
 
1 (0.1%)
125 (2.1%)
IA
563 (68.1%)
862 (24.2%)
 
158 (11.2%)
1583 (26.9%)
IB
4 (0.5%)
299 (8.4%)
2 (2.7%)
68 (4.8%)
373 (6.3%)
IIA
2 (0.2%)
336 (9.4%)
7 (9.5%)
49 (3.5%)
394 (6.7%)
IIB
2 (0.2%)
378 (10.6%)
2 (2.7%)
64 (4.5%)
446 (7.6%)
IIIA
7 (0.8%)
783 (22.0%)
12 (16.2%)
165 (11.7%)
967 (16.5%)
IIIB
5 (0.6%)
354 (9.9%)
13 (17.6%)
92 (6.5%)
464 (7.9%)
IIIC
25 (3.0%)
241 (6.8%)
22 (29.7%)
315 (22.3%)
603 (10.3%)
IV
31 (3.7%)
145 (4.1%)
12 (16.2%)
409 (28.9%)
597 (10.2%)
Unknown
76 (9.2%)
154 (4.3%)
4 (5.4%)
92 (6.5%)
326 (5.5%)
Total
827
3564
74
1413
5878

II. Results of endoscopically treated patients in 2010

Table 9
Details of endoscopic treatment
Treatment details
Cases (%)
EMR
59 (7.8%)
EMR + YAG laser
6 (0.8%)
ESD
667 (88.5%)
ESD + EMR
6 (0.8%)
ESD + PDT
4 (0.5%)
ESD + YAG laser
1 (0.1%)
PDT
3 (0.4%)
YAG laser
8 (1.1%)
Total
754
EMR endoscopic mucosal resection, ESD endoscopic submucosal dissection, YAG yttrium aluminum garnet, PDT photodynamic therapy
Table 10
Complications of EMR/ESD
Complications of EMR/ESD
Cases (%)
None
672 (90.4%)
Perforation
13 (1.7%)
Bleeding
2 (0.3%)
Mediastinitis
4 (0.5%)
Stenosis
44 (5.9%)
Others
8 (1.1%)
Total
743
Table 11
Pathological depth of tumor invasion of EMR/ESD specimens
Pathological depth of tumor invasion (pT)
Cases (%)
pTX
1 (0.1%)
pT0
7 (0.9%)
pTis
163 (21.9%)
pT1a
482 (64.9%)
pT1b
74 (10.0%)
pT2
1 (0.1%)
Unknown
15 (2.0%)
Total
743

III. Results in patients treated with chemotherapy and/or radiotherapy in 2010

Table 12
Dose of irradiation (non-surgically treated cases)
Dose of irradiation (Gy)
Definitive
Palliative (%)
Recurrence (%)
Others (%)
Unknown (%)
Total (%)
Radiation alone (%)
With chemotherapy (%)
≤29
5 (2.9%)
10 (1.4%)
26 (9.2%)
 
1 (2.7%)
 
42 (3.5%)
30–39
1 (0.6%)
7 (1.0%)
43 (15.1%)
3 (10.0%)
4 (10.8%)
 
58 (4.8%)
40–49
9 (5.3%)
24 (3.5%)
36 (12.7%)
1 (3.3%)
10 (27.0%)
 
80 (6.6%)
50–59
27 (15.9%)
173 (25.0%)
60 (21.1%)
9 (30.0%)
13 (35.1%)
1 (33.3%)
283 (23.3%)
60–69
124 (72.9%)
453 (65.5%)
109 (38.4%)
17 (56.7%)
9 (24.3%)
2 (66.7%)
714 (58.7%)
≥70
4 (7.2%)
14 (2.1%)
5 (0.0%)
     
23 (2.2%)
Unknown
 
11 (1.6%)
5 (1.8%)
     
16 (1.3%)
Total
170
692
284
30
37
3
1216
Median (min–max)
60.0 (2.0–105.0)
60.0 (1.8–72.0)
52.5 (1.8–90.0)
60.0 (37.5–67.0)
50.0 (9.0–66.0)
60.0 (52.0–60.0)
60.0 (1.8–105.0)
Table 13
Dose of irradiation (surgically treated cases)
Dose of irradiation (Gy)
Preoperative irradiation (%)
Postoperative irradiation (%)
≤29
2 (1.0%)
 
30–39
34 (17.5%)
1 (2.1%)
40–49
132 (68.0%)
10 (21.3%)
50–59
7 (3.6%)
12 (25.5%)
60–69
13 (6.7%)
22 (46.8%)
≥70
 
2 (1.1%)
Unknown
6 (3.1%)
 
Total
194
47
Median (min–max)
40.0 (0.0–66.0)
60.0 (30.0–79.2)

IV. Results in patients who underwent esophagectomy in 2010

Table 14
Treatment modalities of esophagectomy
Treatments
Cases (%)
Esophagectomy alone
1463 (41.0%)
Esophagectomy + endoscopic treatment
83 (2.3%)
Esophagectomy + chemoradiotherapy
571 (16.0%)
 Concurrent chemoradiotherapy
502 (14.1%)
 Other
69 (1.9%)
Esophagectomy + chemoradiotherapy + endoscopic treatment
13 (0.4%)
Esophagectomy + chemotherapy
1391 (39.0%)
 Preoperative
1027 (28.8%)
 Postoperative
183 (5.1%)
 Pre and postoperative
75 (2.1%)
 Recurrence
46 (1.3%)
 Other
60 (1.7%)
Esophagectomy + chemotherapy + endoscopic treatment
3 (0.1%)
Esophagectomy + radiotherapy
39 (1.1%)
 Preoperative
4 (0.1%)
 Postoperative
7 (0.2%)
 Recurrence
15 (0.4%)
 Other
13 (0.4%)
Esophagectomy + radiotherapy + endoscopic treatment
1 (0.0%)
Total
3564
Table 15
Tumor location
Locations
Cases (%)
Cervical
116 (3.3%)
Upper thoracic
411 (11.5%)
Middle thoracic
1669 (46.8%)
Lower thoracic
1054 (29.6%)
E > G
241 (6.8%)
E = G
38 (1.1%)
G > E
27 (0.8%)
Unknown
8 (0.2%)
Total lesions
3564
Table 16
Approaches to tumor resection
Approaches
Cases (%)
Cervical approach
150 (4.2%)
Right thoracotomy
3010 (84.5%)
Left thoracotomy
50 (1.4%)
Left thoracoabdominal approach
58 (1.6%)
Laparotomy
108 (3.0%)
Transhiatal thoracic esophagectomy
50 (1.4%)
Transhiatal lower esophagectomy
72 (2.0%)
Sternotomy
4 (0.1%)
Others
28 (0.8%)
Unknown
34 (1.0%)
Total
3564
Table 17
Video-assisted surgery
Video-assisted surgery
Cases (%)
None
2117 (59.4%)
Thoracoscopy
653 (18.3%)
Thoracoscopy + laparoscopy
431 (12.1%)
Thoracoscopy + laparoscopy + mediastinoscopy
1 (0.0%)
Thoracoscopy + laparoscopy + other
1 (0.0%)
Laparoscopy
104 (2.9%)
Laparoscopy + mediastinoscopy
8 (0.2%)
Laparoscopy + other
1 (0.0%)
Mediastinoscopy
4 (0.1%)
Others
11 (0.3%)
Total
3564
Table 18
Fields of lymph node dissection according to the location of the tumor
Field of lymphadenectomy
Cervical
Upper thoracic
Middle thoracic
Lower thoracic
E > G
E = G
G > E
Unknown
Total
None
10 (8.6%)
13 (3.2%)
59 (3.5%)
28 (2.7%)
13 (5.4%)
   
2 (25.0%)
125 (3.5%)
C
36 (31.0%)
10 (2.4%)
20 (1.2%)
3 (0.3%)
1 (0.4%)
     
70 (2.0%)
C + UM
21 (18.1%)
6 (1.5%)
3 (0.2%)
1 (0.1%)
       
31 (0.9%)
C + UM + MLM
2 (1.7%)
12 (2.9%)
28 (1.7%)
12 (1.1%)
   
1 (3.7%)
 
55 (1.5%)
C + UM + MLM + A
27 (23.3%)
257 (62.5%)
800 (47.9%)
367 (34.8%)
26 (10.8%)
6 (15.8%)
 
1 (12.5%)
1484 (41.6%)
C + UM + MLM + A+OT
     
1 (0.1%)
       
1 (0.0%)
C + UM + A
2 (1.7%)
1 (0.2%)
2 (0.1%)
2 (0.2%)
       
7 (0.2%)
C + MLM
   
1 (0.1%)
         
1 (0.0%)
C + MLM + A
3 (2.6%)
1 (0.2%)
7 (0.4%)
3 (0.3%)
       
14 (0.4%)
C + A
1 (0.9%)
2 (0.5%)
4 (0.2%)
2 (0.2%)
1 (0.4%)
     
10 (0.3%)
UM
4 (3.4%)
3 (0.7%)
5 (0.3%)
3 (0.3%)
       
15 (0.4%)
UM + MLM
1 (0.9%)
7 (1.7%)
29 (1.7%)
12 (1.1%)
1 (0.4%)
   
1 (12.5%)
51 (1.4%)
UM + MLM + A
3 (2.6%)
75 (18.2%)
627 (37.6%)
478 (45.4%)
56 (23.2%)
5 (13.2%)
1 (3.7%)
1 (12.5%)
1246 (35.0%)
UM + A
1 (0.9%)
4 (1.0%)
2 (0.1%)
2 (0.2%)
2 (0.8%)
     
11 (0.3%)
MLM
 
3 (0.7%)
10 (0.6%)
14 (1.3%)
3 (1.2%)
     
30 (0.8%)
MLM + A
1 (0.9%)
7 (1.7%)
34 (2.0%)
102 (9.7%)
108 (44.8%)
23 (60.5%)
17 (63.0%)
 
292 (8.2%)
A
1 (0.9%)
6 (1.5%)
22 (1.3%)
12 (1.1%)
28 (11.6%)
3 (7.9%)
8 (29.6%)
1 (12.5%)
81 (2.3%)
Unknown
3 (2.6%)
4 (1.0%)
16 (1.0%)
12 (1.1%)
2 (0.8%)
1 (2.6%)
 
2 (25.0%)
40 (1.1%)
Total
116
411
1669
1054
241
38
27
8
3564
C bilateral cervical nodes, UM upper mediastinal nodes, MLM middle-lower mediastinal nodes, A abdominal nodes
Table 19
Reconstruction route
Reconstruction route
Cases (%)
None
57 (1.6%)
Subcutaneous
302 (8.5%)
Retrosternal
1191 (33.4%)
Posterior mediastinal
1473 (41.3%)
Intrathoracic
435 (12.2%)
Cervical
50 (1.4%)
Others
34 (1.0%)
Unknown
22 (0.6%)
Total
3564
Table 20
Organs used for reconstruction
Organs used for reconstruction
Cases (%)
None
72 (2.0%)
Whole stomach
71 (2.0%)
Gastric tube
3059 (85.0%)
Jejunum
176 (4.9%)
Free jejunum
69 (1.9%)
Colon
114 (3.2%)
Free colon
10 (0.3%)
Others
13 (0.4%)
Unknown
16 (0.4%)
Total organs
3600
Total cases
3564
Table 21
Histological classification
Histological classification
Cases (%)
Squamous cell carcinoma
3045 (86.0%)
 Squamous cell carcinoma
584 (16.5%)
 Well differentiated
566 (16.0%)
 Moderately differentiated
1445 (40.8%)
 Poorly differentiated
450 (12.7%)
Adenocarcinoma
161 (4.5%)
Barrett’s adenocarcinoma
71 (2.0%)
Adenosquamous cell carcinoma
20 (0.6%)
Mucoepidermoid carcinoma
3 (0.1%)
Adenoid cystic carcinoma
2 (0.1%)
Basaloid carcinoma
71 (2.0%)
Endocrine cell carcinoma
15 (0.4%)
Undifferentiated carcinoma
6 (0.2%)
Other carcinoma
14 (0.4%)
Carcinosarcoma
18 (0.5%)
Malignant melanoma
16 (0.5%)
GIST
1 (0.0%)
Other
33 (0.9%)
Unknown
66 (1.9%)
Total
3542
Table 22
Depth of tumor invasion, pT (JES 10th)
pT category
Cases (%)
pTX
25 (0.7%)
pT0
79 (2.2%)
pTis
25 (0.7%)
pT1a
373 (10.5%)
pT1b
943 (26.5%)
pT2
450 (12.6%)
pT3
1368 (38.4%)
pT4
111 (3.1%)
pT4a
34 (1.0%)
pT4b
33 (0.9%)
Unknown
123 (3.5%)
Total
3564
Table 23
Pathological grading of lymph node metastasis, pN (JES 10th)
Lymph node metastasis
Cases (%)
pN0
2079 (58.3%)
pN1
474 (13.3%)
pN2
564 (15.8%)
pN3
233 (6.5%)
pN4
149 (4.2%)
Unknown
65 (1.8%)
Total
3564
Table 24
Pathological findings of lymph node metastasis, pN (UICC 7th)
Lymph node metastasis
Cases (%)
pN0
1571 (44.1%)
pN1 (1–2)
956 (26.8%)
pN2 (3–6)
623 (17.5%)
pN3 (7–)
351 (9.8%)
Unknown
63 (1.8%)
Total
3564
Regional lymph nodes are different in JES 10th and UICC 7th
Data for Tables  23 and 24 are analyzed from different variables in the registration application
Table 25
Pathological findings of distant organ metastasis, pM (JES 10th)
Distant metastasis
Cases (%)
pMX
62 (1.7%)
pM0
3446 (96.7%)
pM1
56 (1.6%)
Total
3564
Table 26
Residual tumor
Residual tumor
Cases (%)
RX
156 (4.1%)
R0
3345 (87.0%)
R1
187 (4.9%)
R2
156 (4.1%)
Total
3844
Table 27
Causes of death
Cause of death
Cases (%)
Death due to recurrence
1139 (72.8%)
Death due to other cancer
65 (4.2%)
Death due to other disease (rec+)
44 (2.8%)
Death due to other disease (rec−)
179 (11.4%)
Death due to other disease (rec?)
7 (0.4%)
Operative death*
39 (2.5%)
Postoperative hospital death**
40 (2.6%)
Unknown
52 (3.3%)
Total of death cases
1565 (100%)
rec recurrence
* Operative death means death within 30 days after operation in or out of hospital
** Hospital death is defined as death during the same hospitalization, regardless of department at time of death
Operative mortality after esophagectomy: 0.61%
Hospital mortality after esophagectomy: 4.29%
https://static-content.springer.com/image/art%3A10.1007%2Fs10388-017-0578-4/MediaObjects/10388_2017_578_Figa_HTML.gif

Acknowledgements

This study was supported by Health and Labour Sciences Research Grants for Promotion of Cancer Control Programs (H26-Cancer Policy-General-014) from the Ministry of Health, Labour and Welfare of Japan.

Compliance with ethical standards

Conflict of interest

All authors have nothing to disclose with regard to commercial support.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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