Preface 2013
Contents
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Figure 2 Survival of patients treated with EMR/ESD according to the pathological depth of tumor invasion, pT (JES 10th)
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Figure 9 Survival of patients who underwent esophagectomy according to clinical stage (UICC TNM 7th)
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Figure 10 Survival of patients who underwent esophagectomy according to the depth of tumor invasion, pT (JES 10th)
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Figure 11 Survival of patients who underwent esophagectomy according to lymph node metastasis (JES 10th)
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Figure 12 Survival of patients who underwent esophagectomy according to lymph node metastasis (UICC TNM 7th)
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Figure 13 Survival of patients who underwent esophagectomy according to pathological stage (JES 10th)
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Figure 14 Survival of patients who underwent esophagectomy according to pathological stage (UICC TNM 7th)
I. Clinical features of esophageal cancer patients treated in 2013
Institutions |
---|
Ageo Central General Hospital |
Aichi Cancer Center |
Aichi Medical University Hospital |
Aizawa Hospital |
Akita University Hospital |
Aomori Prefectural Central Hospital |
Arao Municipal Hospital |
Asahikawa Medical University Hospital |
Cancer Institute Hospital of JFCR |
Chiba Cancer Center |
Chiba University Hospital |
Chibaken Saiseikai Narashino Hospital |
Chiba-Nishi General Hospital |
Chigasaki Municipal Hospital |
Chugoku Rosai Hospital |
Dokkyo Medical University Hospital |
Ehime Prefectural Central Hospital |
Eijyu General Hospital |
Fuchinobe General Hospital |
Fuchu Hospital |
Fujinomiya City General Hospital |
Fujioka General Hospital |
Fujisaki Hospital |
Fujita Health University Hospital |
Fukaya Red Cross Hospital |
Fukui Prefectural Hospital |
Fukui University Hospital |
Fukui-ken Saiseikai Hospital |
Fukuoka City Hospital |
Fukuoka Shin Mizumaki Hospital |
Fukuoka University Chikushi Hospital |
Fukuoka University Hospital |
Fukuoka Wajiro Hospital |
Fukushima Medical University Hospital |
Fukuyama City Hospital |
Gifu Prefectural General Center |
Gifu University Hospital |
Gunma Prefectural Cancer Center |
Gunma Saiseikai Maebashi Hospital |
Gunma University Hospital |
Hachinohe City Hospital |
Hakodate City Hospital |
Hakodate Goryokaku Hospital |
Hakodate National Hospital |
Hamamatsu University Hospital |
Heartlife Hospital |
Higashiosaka City Medical Center |
Hiraka General Hospital |
Hiratsuka City Hospital |
Hiratsuka Kyosai Hospital |
Hirosaki University Hospital |
Hiroshima City Asa Hospital |
Hiroshima City Hospital |
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital |
Hiroshima University Hospital |
Hitachi General Hospital |
Hofu Institute of Gastroenterology |
Hokkaido University Hospital |
Hospital of the University of Occupational and Environmental Health, Japan |
Hyogo Cancer Center |
Hyogo Prefectural Amagasaki General Medical Center |
Ibaraki Prefectural Central Hospital |
Iizuka Hospital |
International Goodwill Hospital |
International University of Health and Welfare Atami Hospital |
International University of Health and Welfare Hospital |
International University of Health and Welfare Ichikawa Hospital |
International University of Health and Welfare Mita Hospital |
Isehara Kyodo Hospital |
Ishikawa Prefectural Central Hospital |
Itami City Hospital |
Iwata City Hospital |
Iwate Medical University Hospital |
Iwate Prefectural Central Hospital |
Iwate Prefectural Chubu Hospital |
JA Hiroshima General Hospital |
JA Kouseiren Enshu Hospital |
JA Onomichi General Hospital |
Japanese Red Cross Ashikaga Hospital |
Japanese Red Cross Fukuoka Hospital |
Japanese Red Cross Ishinomaki Hospital |
Japanese Red Cross Kitami Hospital |
Japanese Red Cross Kyoto Daiichi Hospital |
Japanese Red Cross Maebashi Hospital |
Japanese Red Cross Medical Center |
Japanese Red Cross Musashino Hospital |
Japanese Red Cross Nagasaki Genbaku Hospital |
Japanese Red Cross Nagoya Daiichi Hospital |
Japanese Red Cross Saitama Hospital |
Japanese Red Cross Society Nagano Hospital |
Japanese Red Cross Tottori Hospital |
Japanese Red Cross Wakayama Medical Center |
JCHO Gunma Chuo Hospital |
JCHO Kyushu Hospital |
JCHO Miyazaki Konan Hospital |
JCHO Osaka Hospital |
JCHO Saitama Medical Center |
JCHO Tokuyama Central Hospital |
JCHO Yokohama Chuo Hospital |
Jichi Medical University Hospital |
Jichi Medical University Saitama Medical Center |
Juntendo University Hospital |
Juntendo University Shizuoka Hospital |
Juntendo University Urayasu Hospital |
Junwakai Memorial Hospital |
Kagawa Prefectural Central Hospital |
Kagawa Rosai Hospital |
Kagawa University Hospital |
Kagoshima University Hospital |
Kaizuka City Hospital |
Kakogawa Central City hospital |
Kanagawa Cancer Center |
Kanazawa Medical University Hospital |
Kanazawa University Hospital |
Kansai Denryoku Hospital |
Kansai Medical University Hospital |
Kansai Medical University Medical Center |
Kansai Rosai Hospital |
Kanto Central Hospital |
Kashiwa Kousei General Hospital |
Kasugai Municipal Hospital |
Kawasaki Hospital |
Kawasaki Medical School Hospital |
Kawasaki Medical School Kawasaki Hospital |
Kawasaki Municipal Hospital |
Kawasaki Municipal Ida Hospital |
Kawasaki Saiwai Hospital |
Keio University Hospital |
Keiyukai Sapporo Hospital |
Kindai University Hospital |
Kindai University Nara Hospital |
Kinki Central Hospital |
Kiryu Kousei General Hospital |
Kitaakita Municipal Hospital |
Kitaharima Medical Center |
Kitakyushu General Hospital |
Kitakyushu Municipal Medical Center |
Kitano Hospital |
Kitasato University Hospital |
Kobe City Medical Center General Hospital |
Kobe University Hospital |
Kochi Health Science Center |
Kochi University Hospital |
Kokura Memorial Hospital |
Kouseiren Takaoka Hospital |
Kumagai General Hospital |
Kumamoto University Hospital |
Kummoto Regional Medical Center |
Kurashiki Central Hospital |
Kurume University Hospital |
Kyorin University Hospital |
Kyoto University Hospital |
Kyoto-Katsura Hospital |
Kyushu Central Hospital |
Kyushu University Hospital |
Machida Municipal hospital |
Matsudo City General Hospital |
Matsushita Memorial Hospital |
Matsuyama Red Cross Hospital |
Mie University Hospital |
Minamiosaka Hospital |
Minoh City Hospital |
Mito Red Cross Hospital |
Mitsui Memorial Hospital |
Miyazaki University Hospital |
Mizushima Kyudo Hospital |
Moriguchi Keijinkai Hospital |
Murakami General Hospital |
Nagahama City Hospital |
Nagahama Red Cross Hospital |
Nagano Municipal Hospital |
Nagaoka Chuo General Hospital |
Nagasaki University Hospital |
Nagoya City University Hospital |
Nagoya City West Medical Center |
Nagoya University Hospital |
Nanpuh Hospital |
Nara City Hospital |
Nara Medical University Hospital |
Nasu Red Cross Hospital |
National Cancer Center Hospital |
National Cancer Center Hospital East |
National Center for Global Health and Medicine |
National Defence Medical College Hospital |
New Tokyo Hospital |
NHO Beppu Medical Center |
NHO Chiba Medical Center |
NHO Fukuoka-Higashi Medical Center |
NHO Iwakuni Clinincal Center |
NHO Kanmon Medical Center |
NHO Kure Medical Center |
NHO Kyoto Medical Center |
NHO Kyushu Cancer Center |
NHO Matsumoto Medical Center |
NHO Mito Medical Center |
NHO Miyakonojo Medical Center |
NHO Nagasaki Medical Center |
NHO Nagoya Medical Center |
NHO Okayama Medical Center |
NHO Osaka Medical Center |
NHO Saitama Hospital |
NHO Sendai Medical Center |
NHO Shikoku Cancer Center |
NHO Tokyo Medical Center |
NHO Yokohama Medical Center |
Nihonkai General Hospital |
Niigata Cancer Center Hospital |
Niigata City General Hospital |
Niigata Prefectural Central Hospital |
Niigata Prefectural Shibata Hospital |
Niigata University Medical & Detal Hospital |
Nikko Memorial Hospital |
Nippon Medical School Chiba Hokusou Hospital |
Nippon Medical School Hospital |
Nippon Medical School Musashi Kosugi Hospital |
Nippon Medical School Tama Nagayama Hospital |
Nishi Kobe Medical Center |
Nissan Tamagawa Hospital |
Nozaki Tokushukai Hospital |
Numazu City Hospital |
Obihiro Kousei Hospital |
Ogaki Municipal Hospital |
Ohta Hospital |
Ohta Nishinouchi Hospital |
Oita Red Cross Hospital |
Oita University Hospital |
Okayama Red Cross General Hospital |
Okayama Saiseikai General Hospital |
Okayama University Hospital |
Okitama Public General Hospital |
Onomichi Municipal Hospital |
Osaka City General Hospital |
Osaka City University Hospital |
Osaka Ekisaikai Hospital |
Osaka General Medical Center |
Osaka International Cancer Institute |
Osaka Medical College Hospital |
Osaka Police Hospital |
Osaka Red Cross Hospital |
Osaki City Hospital |
Otsu City Hospital |
Rinku General Medical Center |
Saga Prefectural Hospital Koseikan |
Saga University Hospital |
Sagamihara National Hospital |
Saiseikai Fukuoka General Hospital |
Saiseikai Karatsu Hospital |
Saiseikai Noe Hospital |
Saiseikai Utsunomiya Hospital |
Saiseikai Yokohama Tobu Hospital |
Saitama Cancer Center |
Saitama Medical University International Medical Center |
Saitama Medical University Saitama Medical Center |
Sakai City Medical Center |
Saku Central Hospital |
Sapporo Medical University Hospital |
Seikei-kai Chiba Medical Center |
Sendai City Hospital |
Shiga General Hospital |
Shiga University of Medical Science Hospital |
Shimane University Hospital |
Shin Takeo Hospital |
Shinko Hospital |
Shinshu University Hospital |
Shizuoka Cancer Center |
Shizuoka City Shizuoka Hospital |
Shizuoka General Hospital |
Shizuoka Saiseikai General Hospital |
Showa University Hospital |
Southern Tohoku General Hospital |
St. Luke's International Hospital |
St. Marianna University School of Medicine Hospital |
St. Mary's Hospital |
Steel Memorial Yawata Hospital |
Suita Municipal Hospital |
Suzuka Chuo General Hospital |
Tachikawa Hospital |
Takatsuki Red Cross Hospital |
Teikyo University Chiba Medical Center |
Teikyo University Hospital |
Teine Keijinkai Hospital |
Tenri Hospital |
The Hospital of Hyogo College of Medicine |
The Jikei University Daisan Hospital |
The Jikei University Hospital |
Tochigi Cancer Center |
Toho University Ohashi Medical Center |
Toho University Omori Medical Center |
Toho University Sakura Medical Center |
Tohoku University Hospital |
Tokai University Hachioji Hospital |
Tokai University Hospital |
Tokai University Tokyo Hospital |
Tokushima Red Cross Hospital |
Tokushima University Hospital |
Tokyo Dental College Ichikawa General Hospital |
Tokyo Medical and Dental University Hospital |
Tokyo Medical University Hachioji Medical Center |
Tokyo Medical University Hospital |
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
Tokyo Metropolitan Tama Medical Center |
Tokyo Rosai Hospital |
Tokyo University Hospital |
Tokyo Women's Medical University Hospital |
Tokyo Women's Medical University Medical Center East |
Tokyo Women's Medical University Yachiyo Medical Center |
Tonan Hospital |
Toranomon Hospital |
Tosei General Hospital |
Toshima Hospital |
Tottori Prefectural Central Hospital |
Tottori University Hospital |
Toyama Prefectural Central Hospital |
Toyama University Hospital |
Toyonaka Municipal Hospital |
Toyota Memorial Hospital |
Tsuchiura Kyodo Hospital |
Tsukuba University Hospital |
Tsuruoka Municipal Shonal Hospital |
Tsuyama Chuo Hospital |
University Hospital Kyoto Prefectural University of Medicine |
University of the Ryukyus Hospital |
Wakayama Medical University Hospital |
Yamagata Prefectural Central Hospital |
Yamagata University Hospital |
Yamaguchi University Hospital |
Yamanashi Prefectural Central Hospital |
Yamanashi University Hospital |
Yao Municipal Hospital |
Yokohama City Municipal Hospital |
Yokohama City University Hospital |
Yokohama City University Medical Center |
Yokohama Sakae Kyosai Hospital |
Yokosuka General Hospital Uwamachi |
Patient background
Age | Male | Female | Cases (%) |
---|---|---|---|
≤ 29 | 12 | 1 | 13 (0.2%) |
30–39 | 16 | 6 | 22 (0.3%) |
40–49 | 164 | 59 | 223 (2.8%) |
50–59 | 917 | 174 | 1091 (13.6%) |
60–69 | 2675 | 431 | 3106 (38.7%) |
70–79 | 2403 | 437 | 2840 (35.4%) |
80–89 | 570 | 133 | 703 (8.8%) |
90 ≤ | 10 | 11 | 21 (0.3%) |
Total | 6767 | 1252 | 8019 |
Treatments | Cases (%) |
---|---|
Surgery | 5038 (62.8%) |
Esophagectomy | 4910 (61.2%) |
Palliative surgery | 128 (1.6%) |
Chemotherapy and/or Radiotherapy | 4062 (50.7%) |
Endoscopic treatment | 1421 (17.7%) |
Location of tumor | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
Cervical | 48 (3.4%) | 163 (3.3%) | 10 (7.8%) | 256 (6.3%) | 384 (4.8%) |
Upper thoracic | 142 (10.0%) | 525 (10.7%) | 25 (19.5%) | 597 (14.7%) | 969 (12.1%) |
Middle thoracic | 775 (54.5%) | 2188 (44.6%) | 61 (47.7%) | 1864 (45.9%) | 3726 (46.5%) |
Lower thoracic | 369 (26.0%) | 1544 (31.4%) | 26 (20.3%) | 1118 (27.5%) | 2264 (28.2%) |
EG | 61 (4.3%) | 356 (7.3%) | 5 (3.9%) | 165 (4.1%) | 470 (5.9%) |
E = G | 14 (1.0%) | 66 (1.3%) | 23 (0.6%) | 88 (1.1%) | |
GE | 6 (0.4%) | 61 (1.2%) | 15 (0.4%) | 72 (0.9%) | |
Unknown | 6 (0.4%) | 7 (0.1%) | 1 (0.8%) | 45 (0.6%) | 46 (0.6%) |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
Histologic types | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
Squamous cell carcinoma | 1101 (77.5%) | 4291 (87.4%) | 116 (90.6%) | 3733 (91.9%) | 6911 (86.2%) |
Squamous cell carcinoma | 867 (61.0%) | 2442 (49.7%) | 74 (57.8%) | 2330 (57.4%) | 4377 (54.6%) |
Well differentiated | 100 (7.0%) | 387 (7.9%) | 9 (7.0%) | 259 (6.4%) | 565 (7.0%) |
Moderately differentiated | 117 (8.2%) | 1093 (22.3%) | 24 (18.8%) | 805 (19.8%) | 1448 (18.1%) |
Poorly differentiated | 17 (1.2%) | 369 (7.5%) | 9 (7.0%) | 339 (8.3%) | 521 (6.5%) |
Adenocarcinoma | 38 (2.7%) | 340 (6.9%) | 4 (3.1%) | 133 (3.3%) | 419 (5.2%) |
Barrett's carcinoma | 33 (2.3%) | 91 (1.9%) | 1 (0.8%) | 25 (0.6%) | 133 (1.7%) |
Adenosquamous carcinoma | 2 (0.1%) | 11 (0.2%) | 4 (0.1%) | 14 (0.2%) | |
Mucoepidermoid carcinoma | 1 (0.0%) | 1 (0.0%) | |||
Basaloid carcinoma | 2 (0.1%) | 31 (0.6%) | 16 (0.4%) | 39 (0.5%) | |
Neuroendocrine tumor | 1 (0.0%) | 1 (0.0%) | 2 (0.0%) | ||
Neuroendocrine carcinoma | 4 (0.3%) | 21 (0.4%) | 27 (0.7%) | 34 (0.4%) | |
Undifferentiated carcinoma | 6 (0.1%) | 4 (0.1%) | 9 (0.1%) | ||
Malignant melanoma | 15 (0.3%) | 6 (0.1%) | 19 (0.2%) | ||
Carcinosarcoma | 16 (0.3%) | 1 (0.8%) | 8 (0.2%) | 19 (0.2%) | |
GIST | 1 (0.0%) | 1 (0.0%) | |||
Adenoid cystic carcinoma | 1 (0.0%) | 1 (0.0%) | |||
Nonepithelial tumors | 2 (0.1%) | 3 (0.0%) | |||
Other epithelial tumors | 17 (1.2%) | 4 (0.1%) | 8 (0.2%) | 27 (0.3%) | |
Other tumors | 51 (3.6%) | 16 (0.3%) | 13 (0.3%) | 79 (1.0%) | |
Unknown | 171 (12.0%) | 64 (1.3%) | 6 (4.7%) | 84 (2.1%) | 308 (3.8%) |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
Clinical T | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
cTX | 12 (0.8%) | 11 (0.2%) | 1 (0.8%) | 34 (0.8%) | 80 (1.0%) |
cT0 | 6 (0.6%) | 4 (0.1%) | 3 (0.1%) | 14 (0.2%) | |
cT1a | 1139 (80.2%) | 247 (5.0%) | 102 (2.5%) | 1426 (17.8%) | |
cT1b | 196 (13.8%) | 1319 (26.9%) | 9 (7.0%) | 515 (12.7%) | 1658 (20.7%) |
cT2 | 4 (0.3%) | 832 (16.9%) | 4 (3.1%) | 609 (15.0%) | 1006 (12.5%) |
cT3 | 41 (2.9%) | 2223 (45.3%) | 49 (38.3%) | 2036 (50.1%) | 2895 (36.1%) |
cT4a | 4 (0.3%) | 133 (2.7%) | 17 (13.3%) | 257 (6.3%) | 341 (4.3%) |
cT4b | 19 (1.3%) | 141 (2.9%) | 48 (37.5%) | 506 (12.5%) | 599 (7.5%) |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
Clinical N | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
cN0 | 1351 (95.1%) | 2278 (46.4%) | 31 (24.2%) | 1117 (27.5%) | 4047 (50.5%) |
cN1 | 38 (2.7%) | 1704 (34.7%) | 37 (28.9%) | 1663 (40.9%) | 2318 (28.9%) |
cN2 | 22 (1.5%) | 800 (16.3%) | 43 (33.6%) | 1009 (24.8%) | 1301 (16.2%) |
cN3 | 10 (0.7%) | 128 (2.6%) | 17 (13.3%) | 273 (6.7%) | 353 (4.4%) |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
Clinical M | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
cM0 | 1406 (98.9%) | 4753 (96.8%) | 103 (80.5%) | 3513 (86.5%) | 7350 (91.7%) |
cM1 | 15 (1.1%) | 157 (3.2%) | 25 (19.5%) | 549 (13.5%) | 669 (8.3%) |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
Clinical stage | Endoscopic treatment | Surgery | Chemotherapy and/or radiotherapy (%) | Total (%) | |
---|---|---|---|---|---|
(%) | Esophagectomy (%) | Palliative surgery (%) | |||
Stage IA | 1317 (92.7%) | 1268 (25.8%) | 7 (5.5%) | 388 (9.6%) | 2712 (33.8%) |
Stage IB | 3 (0.2%) | 417 (8.5%) | 3 (2.3%) | 252 (6.2%) | 492 (6.1%) |
Stage IIA | 8 (0.6%) | 523 (10.7%) | 10 (7.8%) | 356 (8.8%) | 629 (7.8%) |
Stage IIB | 15 (1.1%) | 522 (10.6%) | 389 (9.6%) | 609 (7.6%) | |
Stage IIIA | 19 (1.3%) | 1169 (23.8%) | 14 (10.9%) | 952 (23.4%) | 1375 (17.1%) |
Stage IIIB | 9 (0.6%) | 514 (10.5%) | 14 (10.9%) | 488 (12.0%) | 642 (8.0%) |
Stage IIIC | 17 (1.2%) | 325 (6.6%) | 55 (43.0%) | 667 (16.4%) | 821 (10.2%) |
Stage IV | 15 (1.1%) | 157 (3.2%) | 25 (19.5%) | 549 (13.5%) | 669 (8.3%) |
Unknown | 18 (1.3%) | 15 (0.3%) | 21 (0.5%) | 70 (0.9%) | |
Total | 1421 | 4910 | 128 | 4062 | 8019 |
II. Results of endoscopically treated patients in 2013
Treatment details | Cases (%) |
---|---|
EMR | 108 (8.0%) |
EMR + YAG laser | 1 (0.1%) |
EMR + MCT/RFA | |
ESD | 1224 (90.2%) |
ESD + EMR | 4 (0.3%) |
ESD + PDT | |
ESD + YAG laser | 5 (0.4%) |
PDT | 2 (0.1%) |
YAG laser | 13 (1.0%) |
Total | 1357 |
Complications of EMR/ESD | Cases (%) |
---|---|
None | 1298 (92.7%) |
Perforation | 10 (0.7%) |
Bleeding | 1 (0.1%) |
Mediastinitis | 1 (0.1%) |
Stenosis | 23 (1.7%) |
Others | |
Unknown | 2 (0.1%) |
Total | 1335 |
Pathological depth of tumor invasion (pT) | Cases (%) |
---|---|
pTX | 22 (1.6%) |
pT0 | 7 (0.5%) |
pT1a | 1111 (82.8%) |
pT1b | 201 (15.0%) |
pT2 | |
pT3 | 1 (0.1%) |
Total | 1342 |
III. Results in patients treated with chemotherapy and/or radiotherapy in 2013
Dose of irradiation (Gy) | Definitive | Palliative (%) | Recurrence (%) | Others (%) | Total (%) | |
---|---|---|---|---|---|---|
Radiation alone (%) | With chemotherapy (%) | |||||
–29 | 2 (1.5%) | 20 (2.4%) | 23 (11.7%) | 2 (5.9%) | 1 (10.0%) | 48 (4.0%) |
30–39 | 4 (3.0%) | 16 (1.9%) | 33 (16.8%) | 1 (2.9%) | 2 (20.0%) | 56 (4.7%) |
40–49 | 7 (5.3%) | 33 (4.0%) | 40 (20.4%) | 1 (2.9%) | 3 (30.0%) | 84 (7.0%) |
50–59 | 15 (11.4%) | 233 (28.2%) | 35 (17.9%) | 10 (29.4%) | 2 (20.0%) | 295 (24.6%) |
60–69 | 98 (74.2%) | 505 (61.1%) | 63 (32.1%) | 19 (55.9%) | 2 (20.0%) | 687 (57.3%) |
70– | 6 (4.5%) | 18 (2.2%) | 1 (0.5%) | 1 (2.9%) | 26 (2.2%) | |
Unknown | 2 (0.2%) | 1 (0.5%) | 3 (0.3%) | |||
Total | 132 | 827 | 196 | 34 | 10 | 1199 |
Median (min–max) | 60.0 (5.4–80.0) | 60.0 (2.0–99.0) | 50.0 (2.0–70.0) | 60.0 (11.0–70.0) | 43.2 (26.0–66.0) | 60.0 (2.0–99.0) |
Dose of irradiation (Gy) | Preoperative irradiation (%) | Postoperative irradiation (%) |
---|---|---|
–29 | 4 (1.4%) | 6 (10.0%) |
30–39 | 62 (22.2%) | 3 (5.0%) |
40–49 | 177 (63.4%) | 5 (8.3%) |
50–59 | 19 (6.8%) | 19 (31.7%) |
60–69 | 10 (3.6%) | 24 (40.0%) |
70– | 4 (1.4%) | 2 (3.3%) |
Unknown | 3 (1.1%) | 1 (1.7%) |
Total | 279 | 60 |
Median (min–max) | 40.0 (2.0–99.0) | 55.0 (16.0–75.9) |
IV. Results in patients who underwent esophagectomy in 2013
Treatment modalities | Cases (%) |
---|---|
Esophagectomy alone | 2336 (47.6%) |
Esophagectomy + postoperative chemotherapy | 385 (7.8%) |
Esophagectomy + postoperative chemoradiotherapy | 109 (2.2%) |
Esophagectomy + postoperative radiotherapy | 34 (0.7%) |
Preoperative chemotherapy + esophagectomy | 1558 (31.7%) |
Preoperative chemoradiotherapy + esophagectomy | 286 (5.8%) |
Definitive radiotherapy + esophagectomy | 6 (0.1%) |
Definitive chemoradiotherapy + esophagectomy | 101 (2.1%) |
Others | 95 (1.9%) |
Total | 4910 |
Locations | Cases (%) |
---|---|
Cervical | 166 (3.4%) |
Upper thoracic | 536 (10.9%) |
Middle thoracic | 2165 (44.1%) |
Lower thoracic | 1507 (30.7%) |
EG | 368 (7.5%) |
E = G | 85 (1.7%) |
GE | 72 (1.5%) |
Unknown | 11 (0.2%) |
Total | 4910 |
Approaches | Cases (%) |
---|---|
Cervical | 135 (2.7%) |
Right thoracic | 4171 (84.9%) |
Left thoracic | 63 (1.3%) |
Left thoracoabdominal | 115 (2.3%) |
Abdominal | 171 (3.5%) |
Transhiatal lower esophagectomy | 94 (1.9%) |
Transhiatal thoracic esophagectomy | 100 (2.0%) |
Sternotomy | 2 (0.0%) |
Others | 46 (0.9%) |
Unknown | 13 (0.3%) |
Total | 4910 |
Video-assisted surgery | Cases (%) |
---|---|
None | 2444 (49.8%) |
Thoracoscopy | 1072 (21.8%) |
Thoracoscopy + laparoscopy | 1037 (21.1%) |
Thoracoscopy + laparoscopy + mediastinoscopy | 5 (0.1%) |
Thoracoscopy + laparoscopy + other | |
Thoracoscopy + mediastinoscopy | |
Thoracoscopy + other | 1 (0.0%) |
Laparoscopy | 237 (4.8%) |
Laparoscopy + mediastinoscopy | 11 (0.2%) |
Laparoscopy + mediastinoscopy + other | 11 (0.3%) |
Mediastinoscopy | 57 (1.2%) |
Laparoscopy + other | 2 (0.0%) |
Others | 30 (0.6%) |
Unknown | 3 (0.1%) |
Total | 4910 |
Field of lymphadenectomy | Cervical | Upper thoracic | Middle thoracic | Lower thoracic | Abdominal | E = G | GE | Unknown | Total |
---|---|---|---|---|---|---|---|---|---|
None | 5 (3.0%) | 15 (2.8%) | 24 (1.1%) | 31 (2.1%) | 6 (1.6%) | 2 (2.4%) | 2 (2.8%) | 3 (27.3%) | 88 (1.8%) |
C | 36 (21.7%) | 8 (1.5%) | 16 (0.7%) | 10 (0.7%) | 70 (1.4%) | ||||
C + UM | 21 (12.7%) | 1 (0.2%) | 1 (0.0%) | 4 (0.3%) | 1 (9.1%) | 28 (0.6%) | |||
C + UM + MLM | 10 (6.0%) | 14 (2.6%) | 47 (2.2%) | 15 (1.0%) | 1 (0.3%) | 87 (1.8%) | |||
C + UM + MLM + A | 69 (41.6%) | 336 (62.7%) | 1098 (50.7%) | 532 (35.3%) | 62 (16.8%) | 10 (11.8%) | 1 (1.4%) | 5 (45.5%) | 2113 (43.0%) |
C + UM + A | 5 (3.0%) | 4 (0.7%) | 17 (0.8%) | 7 (0.5%) | 1 (0.3%) | 1 | 35 (0.7%) | ||
C + MLM | 1 (0.1%) | 1 (0.0%) | |||||||
C + MLM + A | 3 (1.8%) | 6 (1.1%) | 14 (0.6%) | 9 (0.6%) | 1 (0.3%) | 33 (0.7%) | |||
C + A | 3 (1.8%) | 3 (0.6%) | 4 (0.2%) | 6 (0.4%) | 1 (1.4%) | 17 (0.3%) | |||
UM | 1 (0.6%) | 2 (0.4%) | 9 (0.4%) | 1 (0.1%) | 1 (0.3%) | 14 (0.3%) | |||
UM + MLM | 3 (1.8%) | 8 (1.5%) | 41 (1.9%) | 24 (1.6%) | 5 (1.4%) | 1 (1.2%) | 82 (1.7%) | ||
UM + MLM + A | 3 (1.8%) | 124 (23.1%) | 792 (36.6%) | 668 (44.3%) | 116 (31.5%) | 16 (18.8%) | 10 (13.9%) | 1729 (35.2%) | |
UM + A | 2 (0.4%) | 12 (0.6% | 9 (0.6%) | 2 (0.5%) | 25 (0.5%) | ||||
MLM | 3 (0.6%) | 8 (0.4%) | 8 (0.5%) | 4 (1.1%) | 1 1.2%) | 2 (2.8%) | 26 (0.5%) | ||
MLM + A | 3 (1.8%) | 4 (0.7%) | 62 (2.9%) | 154 (10.2%) | 141 (38.3%) | 43 (50.6%) | 39 (54.2%) | 446 (9.1%) | |
A | 4 (2.4%) | 6 (1.1%) | 20 (0.9%) | 28 (1.9%) | 28 (7.6%) | 12 (14.1%) | 16 (22.0%) | 2 (18.2%) | 116 (2.4%) |
Total | 166 | 536 | 2165 | 1507 | 368 | 85 | 72 | 11 | 4910 |
Route | Cases (%) |
---|---|
None | 62 (1.3%) |
Subcutaneous | 353 (7.2%) |
Retrosternal | 1971 (40.1%) |
Posterior mediastinal | 1972 (40.2%) |
Intrathoracic | 462 (9.4%) |
Cervical | 49 (1.0%) |
Others | 26 (0.5%) |
Unknown | 15 (0.3%) |
Total | 4910 |
Organs | Cases (%) |
---|---|
None | 88 (1.3%) |
Whole stomach | 215 (4.3%) |
Gastric tube | 4114 (83.1%) |
Jejunum | 249 (5.0%) |
Free jejunum | 85 (1.7%) |
Colon | 162 (3.3%) |
Free colon | 8 (0.2%) |
Others | 32 (0.6%) |
Total organs | 4953 |
Total cases | 4822 |
Histological classification | Cases (%) |
---|---|
Squamous cell carcinoma | 4086 (83.2%) |
Squamous cell carcinoma | 756 (15.4%) |
Well differentiated | 750 (15.3%) |
Moderately differentiated | 1989 (40.5%) |
Poorly differentiated | 591 (12.0%) |
Adenocarcinoma | 306 (6.2%) |
Barrett's carcinoma | 118 (2.4%) |
Adenosquamous carcinoma | 22 (0.4%) |
Mucoepidermoid carcinoma | 1 (0.0%) |
Basaloid carcinoma | 86 (1.8%) |
Neuroendocrine tumor | 1 (0.0%) |
Neuroendocrine carcinoma | 32 (0.7%) |
Undifferentiated carcinoma | 8 (0.2%) |
Malignant melanoma | 16 (0.3%) |
Carcinosarcoma | 43 (0.9%) |
GIST | 2 (0.0%) |
Adenoid cystic carcinoma | 3 (0.1%) |
Sarcoma | 2 (0.0%) |
Other carcinomas | 3 (0.1%) |
Other tumors | 41 (0.8%) |
Unknown | 140 (2.9%) |
Total | 4910 |
Pathological depth of tumor invasion | Cases (%) |
---|---|
pTx | 72 (1.5%) |
pT0 | 161 (3.3%) |
pT1a | 589 (12.0%) |
pT1b | 1339 (27.3%) |
pT2 | 607 (12.4%) |
pT3 | 1898 (38.7%) |
pT4a | 138 (0.8%) |
pT4b | 106 (2.2%) |
Total | 4910 |
Lymph node metastasis | Cases (%) |
---|---|
pN0 | 2335 (47.6%) |
pN1 | 936 (19.1%) |
pN2 | 1000 (20.4%) |
pN3 | 354 (7.2%) |
pN4 | 254 (5.2%) |
Unknown | 31 (0.6%) |
Total | 4910 |
Lymph node metastasis | Cases (%) |
---|---|
pN0 | 2361 (48.1%) |
pN1 (1–2) | 1374 (28.0%) |
pN2 (3–6) | 757 (15.4%) |
pN3 (7–) | 366 (7.5%) |
Unknown | 52 (1.1%) |
Total | 4910 |
Distant metastasis (M) | Cases (%) |
---|---|
MX | 125 (2.5%) |
M0 | 4715 (96.0%) |
M1 | 70 (1.4%) |
Total | 4910 |
Residual tumor (R) | Cases (%) |
---|---|
RX | 126 (2.6%) |
R0 | 4359 (88.8%) |
R1 | 239 (4.9%) |
R2 | 186 (3.8%) |
Total | 4910 |
Cause of death | Cases (%) |
---|---|
Death due to recurrence | 1584 (63.8%) |
Death due to other cancer | 193 (7.8%) |
Death due to other disease (with recurrence) | 50 (2.0%) |
Death due to other disease (without recurrence) | 330 (13.3%) |
Death due to other disease (recurrence unknown) | 15 (0.6%) |
Operative deatha | 38 (1.5%) |
Postoperative hospital deathb | 59 (2.4%) |
Unknown | 213 (8.6%) |
Total of death cases | 2482 |