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Journal of Gambling Studies

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01.06.2015 | Original Paper

COMT Associations with Disordered Gambling and Drinking Measures

verfasst von: Casey R. Guillot, Jennifer R. Fanning, Tiebing Liang, Mitchell E. Berman

Erschienen in: Journal of Gambling Studies | Ausgabe 2/2015

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Abstract

Disordered gambling and alcohol dependence are influenced by unique and shared genetic factors. Although the evidence is mixed, some research has linked catechol-O-methyltransferase (COMT) rs4680 (or COMT Val158Met) to the development of gambling or drinking problems; however, no molecular genetic study has jointly examined gambling and drinking problems. Furthermore, the majority of past studies examined gambling or drinking problems using a case–control design. The purpose of the current study was to examine associations of COMT rs4680 with dimensionally and categorically measured gambling and drinking problems in a nonclinical sample (139 Caucasian adults). The current study found that COMT rs4680 was related to both dimensionally and categorically measured gambling and drinking problems. It appears that the COMT Met/Met genotype may be a genetic risk factor that contributes to the development of both gambling and drinking problems.

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Titel: COMT Associations with Disordered Gambling and Drinking Measures
verfasst von: Casey R. Guillot
Jennifer R. Fanning
Tiebing Liang
Mitchell E. Berman
Publikationsdatum: 01.06.2015
Verlag: Springer US
Erschienen in: Journal of Gambling Studies / Ausgabe 2/2015
Elektronische ISSN: 1573-3602
DOI: https://doi.org/10.1007/s10899-013-9434-1

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COMT Associations with Disordered Gambling and Drinking Measures

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