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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

BMC Gastroenterology 1/2014

Concurrent autoimmune pancreatitis and primary Biliary cirrhosis: a rare case report and literature review

Zeitschrift:
BMC Gastroenterology > Ausgabe 1/2014
Autoren:
Aiqing Li, Yongjie Wang, Zheng Deng
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-230X-14-10) contains supplementary material, which is available to authorized users.

Competing interests

All authors declare no competing interest.

Authors’ contributions

LAQ and WYJ drafted the first manuscript and made a contribution to data acquisition and interpretation. LAQ and DZ performed the clinical work-up and literature search. WYJ and DZ revised the language and grammar of the manuscript. WYJ and LAQ revised the manuscript to get final approval of the current submission. All authors read and approved the final manuscript.

Abstract

Background

Both autoimmune pancreatitis (AIP) and primary biliary cirrhosis (PBC) are related to various diseases. But the concurrence of AIP and PBC is extremely rare, with only 2 cases reported. Here we report the concurrence of AIP and PBC in a Chinese patient for the first time.

Case presentation

A 65-year-old male was admitted to our hospital with jaundice, pruritus, mild abdominal pain and darkening urine. Serum alkaline phosphatase, γ-glutamyltransferase, bilirubin and IgG4 were prominently elevated. The antimitochondrial antibody was positive. Radiological examination revealed diffusive enlargement of the pancreas. Pancreatic biopsy showed lymphoplasmacytic infiltration, fibrosis and abundant IgG4+ plasma cells. The patient was diagnosed with AIP and PBC. Nasobiliary tube was placed to facilitate biliary drainage. A combination therapy of steroid and UDCA was administered and the patient was gradually recovered, during which the patient was complicated with biliary infecion, herpes zoster and pulmonary abscess.

Conclusion

We present this case together with literature evidence to support the concurrence of AIP and PBC, share our experience of using combination therapy with steroid and UDCA, and raise the awareness of infectious complications in immunosuppressed patients.
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