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Virchows Archiv
Erschienen in: Virchows Archiv 3/2009

01.03.2009 | Original Article

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

verfasst von: Marilena Vered, Alex Dobriyan, Amos Buchner

Erschienen in: Virchows Archiv | Ausgabe 3/2009

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Abstract

Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-α, which further contributes to the distinction between a CGCE and the adult GCT.
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Metadaten
Titel
Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult
verfasst von
Marilena Vered
Alex Dobriyan
Amos Buchner
Publikationsdatum
01.03.2009
Verlag
Springer-Verlag
Erschienen in
Virchows Archiv / Ausgabe 3/2009
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-009-0733-y

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