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Current Neurology and Neuroscience Reports

Erschienen in:

01.08.2017 | Nerve and Muscle (L H Weimer, Section Editor)

Congenital Myasthenic Syndromes in 2018

verfasst von: Andrew G. Engel

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 8/2018

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Abstract

Purpose of Review

Summarize features of the currently recognized congenital myasthenic syndromes (CMS) with emphasis on novel findings identified in the past 6 years.

Recent Findings

Since the last review of the CMS in this journal in 2012, several novel CMS were identified. The identified disease proteins are SNAP25B, synaptotagmin 2, Munc13-1, synaptobrevin-1, GFPT1, DPAGT1, ALG2, ALG14, Agrin, GMPPB, LRP4, myosin 9A, collagen 13A1, the mitochondrial citrate carrier, PREPL, LAMA5, the vesicular ACh transporter, and the high-affinity presynaptic choline transporter.

Summary

Exome sequencing has provided a powerful tool for identifying novel CMS. Identifying the disease genes is essential for determining optimal therapy. The landscape of the CMS is still unfolding.

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Titel: Congenital Myasthenic Syndromes in 2018
verfasst von: Andrew G. Engel
Publikationsdatum: 01.08.2017
Verlag: Springer US
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 8/2018
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-018-0852-4

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