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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Journal of Medical Case Reports 1/2014

Conjunctival sarcoidosis presenting as limbal conjunctival hypertrophy: a case report

Journal of Medical Case Reports > Ausgabe 1/2014
Sang Beom Han, Hee Kyung Yang, Joon Young Hyon, Won Ryang Wee
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-8-63) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contribution

SBH and HKY acquired, analyzed and interpreted the patient data regarding the sarcoidosis. JYH and WRW performed the histological examination of the conjunctival tissue sample. SBH and HKY were major contributors in writing the manuscript, and JYH and WRW revised it critically. All authors read and approved the final manuscript.



To the best of our knowledge, this is the first report of a case of conjunctival sarcoidosis that presented as limbal conjunctival hypertrophy and was controlled with topical cyclosporine.

Case presentation

A 70-year-old Asian woman presented with painless limbal conjunctival hypertrophy. An incisional biopsy of the hypertrophic lesion showed noncaseating granulomas that consisted of multinucleated giant cells and epithelioid cells. The results of a systemic evaluation were normal except for a slight increase in serum angiotensin-converting enzyme to 58.9IU/L (normal range, 8 to 55IU/L). Twice-daily 0.05% topical cyclosporine was prescribed for the treatment of remaining lesions. After two months, the lesions had completely resolved and her serum angiotensin-converting enzyme level had normalized.


Sarcoidosis should be considered in the differential diagnosis of conjunctival hypertrophy. Topical cyclosporine can be useful in conjunctival sarcoidosis.

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