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01.02.2014 | Original Article

Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation

verfasst von: Judith Stift, Hideo A. Baba, Elisabeth Huber, Birgit Federmann, Hans-Peter Fischer, Annette Schmitt-Graeff, Herrad Baurmann, Wolfgang Bethge, Peter Schirmacher, Fritz Wrba, Hildegard Greinix, Falko Fend, Rainer Schwerdtfeger, Howard M. Shulman, Daniel Wolff, Thomas Longerich, on behalf of the Liver Pathology Group of the German-Austrian-Swiss Working Group on GvHD

Erschienen in: Virchows Archiv | Ausgabe 2/2014

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Abstract

After allogeneic hematopoietic cell transplantation (alloHCT) liver biopsy is performed for enigmatic liver disorders when noninvasive diagnostic steps have failed in establishing a definitive diagnosis. This document provides an updated consensus on the prerequisites for proper evaluation of liver biopsies in alloHCT patients and the histological diagnostic criteria for liver graft-versus-host disease (GvHD). The Working Group’s recommendations for the histological diagnosis of liver GvHD were derived from the peer-reviewed literature and from the consensus diagnosis of a total of 30 coded liver biopsies. Acceptance of the recommendations was tested by a survey distributed to all HCT centers in Austria, Germany and Switzerland. Consensus was achieved for biopsy indications, methods of sample acquisition and processing, reporting and interpretation of biopsy findings. As GvHD is variably treated and the treatment modalities have changed over time, the panel endorses the use of more frequent biopsies in clinical studies in order to improve the present challenging clinical and diagnostic situation.

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Titel: Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation
verfasst von: Judith Stift
Hideo A. Baba
Elisabeth Huber
Birgit Federmann
Hans-Peter Fischer
Annette Schmitt-Graeff
Herrad Baurmann
Wolfgang Bethge
Peter Schirmacher
Fritz Wrba
Hildegard Greinix
Falko Fend
Rainer Schwerdtfeger
Howard M. Shulman
Daniel Wolff
Thomas Longerich
on behalf of the Liver Pathology Group of the German-Austrian-Swiss Working Group on GvHD
Publikationsdatum: 01.02.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 2/2014
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-013-1528-8

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Springer Medizin

Abstract

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