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Erschienen in:

03.09.2024 | Pediatric Gastroenterology (S Saeed and E Mezoff, Section Editors)

Constipation in Children with Autism: A Comprehensive Review

verfasst von: Ashish Chogle, Gregory Wong, J. Thomas Megerian

Erschienen in: Current Treatment Options in Pediatrics | Ausgabe 4/2024

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Abstract

Purpose of review

This review examines the multifaceted relationship between constipation and Autism Spectrum Disorder (ASD), aiming to understand the underlying mechanisms and influence of dietary, behavioral, and neurodevelopmental factors. It addresses how these elements contribute to the prevalence and management of gastrointestinal issues in children with ASD.

Recent findings

Recent studies emphasize the significant impact of the gut-brain axis and the role of the microbiome in modulating gastrointestinal and neurological health in ASD. Research highlights that alterations in gut microbiota may influence neurodevelopmental outcomes through mechanisms such as inflammation and neurotransmitter modulation. The review also underscores the challenges posed by restrictive dietary habits and sensory sensitivities that are prevalent in children with ASD. These dietary issues not only exacerbate constipation but also complicate its management. Additionally, the interplay between ASD-related behavioral issues and physical inactivity further impacts bowel health, making management strategies like diet modification and medication more complex.

Summary

The review suggests that effective management of constipation in children with ASD requires a comprehensive and multidisciplinary approach tailored to the individual’s dietary preferences, sensory sensitivities, and behavioral patterns. It is crucial to integrate strategies that address the gut-brain connection and consider the broader neurodevelopmental context. Future research should continue to explore this complex interplay to develop more effective interventions that can improve gastrointestinal and overall health outcomes for children with ASD.
Literatur
1.
Zurück zum Zitat McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014;133(5):872–83.PubMedCrossRef McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014;133(5):872–83.PubMedCrossRef
2.
Zurück zum Zitat Buie T, Fuchs GJ 3rd, Furuta GT, Kooros K, Levy J, Lewis JD, et al. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010;125(Suppl 1):S19-29.PubMedCrossRef Buie T, Fuchs GJ 3rd, Furuta GT, Kooros K, Levy J, Lewis JD, et al. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010;125(Suppl 1):S19-29.PubMedCrossRef
3.
Zurück zum Zitat Holingue C, Newill C, Lee LC, Pasricha PJ, Daniele FM. Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Res. 2018;11(1):24–36.PubMedCrossRef Holingue C, Newill C, Lee LC, Pasricha PJ, Daniele FM. Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Res. 2018;11(1):24–36.PubMedCrossRef
4.
Zurück zum Zitat Wang LW, Tancredi DJ, Thomas DW. The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. J Dev Behav Pediatr. 2011;32(5):351–60.PubMedCrossRef Wang LW, Tancredi DJ, Thomas DW. The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. J Dev Behav Pediatr. 2011;32(5):351–60.PubMedCrossRef
5.
Zurück zum Zitat Peeters B, Noens I, Philips EM, Kuppens S, Benninga MA. Autism spectrum disorders in children with functional defecation disorders. J Pediatr. 2013;163(3):873–8.PubMedCrossRef Peeters B, Noens I, Philips EM, Kuppens S, Benninga MA. Autism spectrum disorders in children with functional defecation disorders. J Pediatr. 2013;163(3):873–8.PubMedCrossRef
6.
Zurück zum Zitat Pang KH, Croaker GD. Constipation in children with autism and autistic spectrum disorder. Pediatr Surg Int. 2011;27(4):353–8.PubMedCrossRef Pang KH, Croaker GD. Constipation in children with autism and autistic spectrum disorder. Pediatr Surg Int. 2011;27(4):353–8.PubMedCrossRef
7.
Zurück zum Zitat Niemczyk J, Wagner C, von Gontard A. Incontinence in autism spectrum disorder: a systematic review. Eur Child Adolesc Psychiatry. 2018;27(12):1523–37.PubMedCrossRef Niemczyk J, Wagner C, von Gontard A. Incontinence in autism spectrum disorder: a systematic review. Eur Child Adolesc Psychiatry. 2018;27(12):1523–37.PubMedCrossRef
8.
Zurück zum Zitat Seidler GR, Knaus ME, Beyene TJ, Ahmad H, Lu PL, Gasior AC, et al. Impact of Neurodevelopmental Disorders on Bowel Management Outcomes in Children with Functional Constipation. J Pediatr Gastroenterol Nutr. 2022;75(3):286–92.PubMedCrossRef Seidler GR, Knaus ME, Beyene TJ, Ahmad H, Lu PL, Gasior AC, et al. Impact of Neurodevelopmental Disorders on Bowel Management Outcomes in Children with Functional Constipation. J Pediatr Gastroenterol Nutr. 2022;75(3):286–92.PubMedCrossRef
9.
Zurück zum Zitat Gorrindo P, Williams KC, Lee EB, Walker LS, McGrew SG, Levitt P. Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res. 2012;5(2):101–8.PubMedPubMedCentralCrossRef Gorrindo P, Williams KC, Lee EB, Walker LS, McGrew SG, Levitt P. Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res. 2012;5(2):101–8.PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Sparks B, Cooper J, Hayes C, Williams K. Constipation in Children with Autism Spectrum Disorder Associated with Increased Emergency Department Visits and Inpatient Admissions. J Pediatr. 2018;202:194–8.PubMedCrossRef Sparks B, Cooper J, Hayes C, Williams K. Constipation in Children with Autism Spectrum Disorder Associated with Increased Emergency Department Visits and Inpatient Admissions. J Pediatr. 2018;202:194–8.PubMedCrossRef
11.
Zurück zum Zitat Chaidez V, Hansen RL, Hertz-Picciotto I. Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord. 2014;44(5):1117–27.PubMedPubMedCentralCrossRef Chaidez V, Hansen RL, Hertz-Picciotto I. Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord. 2014;44(5):1117–27.PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Jamka JR, Gulbransen BD. Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction. Neurogastroenterol Motil. 2024:e14870 Jamka JR, Gulbransen BD. Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction. Neurogastroenterol Motil. 2024:e14870
13.
14.
Zurück zum Zitat Cermak SA, Curtin C, Bandini LG. Food selectivity and sensory sensitivity in children with autism spectrum disorders. J Am Diet Assoc. 2010;110(2):238–46.PubMedPubMedCentralCrossRef Cermak SA, Curtin C, Bandini LG. Food selectivity and sensory sensitivity in children with autism spectrum disorders. J Am Diet Assoc. 2010;110(2):238–46.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Sauer AK, Malijauskaite S, Meleady P, Boeckers TM, McGourty K, Grabrucker AM. Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders. Cell Mol Life Sci. 2021;79(1):46.PubMedPubMedCentralCrossRef Sauer AK, Malijauskaite S, Meleady P, Boeckers TM, McGourty K, Grabrucker AM. Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders. Cell Mol Life Sci. 2021;79(1):46.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451–63.PubMedPubMedCentralCrossRef Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451–63.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Tye C, Runicles AK, Whitehouse AJO, Alvares GA. Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review. Front Psychiatry. 2018;9:751.PubMedCrossRef Tye C, Runicles AK, Whitehouse AJO, Alvares GA. Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review. Front Psychiatry. 2018;9:751.PubMedCrossRef
19.
Zurück zum Zitat De Sales-Millán A, Aguirre-Garrido JF, González-Cervantes RM, Velázquez-Aragón JA. Microbiome-Gut-Mucosal-Immune-Brain Axis and Autism Spectrum Disorder (ASD): A Novel Proposal of the Role of the Gut Microbiome in ASD Aetiology. Behav Sci (Basel). 2023;13(7) De Sales-Millán A, Aguirre-Garrido JF, González-Cervantes RM, Velázquez-Aragón JA. Microbiome-Gut-Mucosal-Immune-Brain Axis and Autism Spectrum Disorder (ASD): A Novel Proposal of the Role of the Gut Microbiome in ASD Aetiology. Behav Sci (Basel). 2023;13(7)
20.
Zurück zum Zitat Baraskewich J, von Ranson KM, McCrimmon A, McMorris CA. Feeding and eating problems in children and adolescents with autism: A scoping review. Autism. 2021;25(6):1505–19.PubMedPubMedCentralCrossRef Baraskewich J, von Ranson KM, McCrimmon A, McMorris CA. Feeding and eating problems in children and adolescents with autism: A scoping review. Autism. 2021;25(6):1505–19.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Leader G, Tuohy E, Chen JL, Mannion A, Gilroy SP. Feeding Problems, Gastrointestinal Symptoms, Challenging Behavior and Sensory Issues in Children and Adolescents with Autism Spectrum Disorder. J Autism Dev Disord. 2020;50(4):1401–10.PubMedCrossRef Leader G, Tuohy E, Chen JL, Mannion A, Gilroy SP. Feeding Problems, Gastrointestinal Symptoms, Challenging Behavior and Sensory Issues in Children and Adolescents with Autism Spectrum Disorder. J Autism Dev Disord. 2020;50(4):1401–10.PubMedCrossRef
22.
Zurück zum Zitat Kerwin ME, Eicher PS, Gelsinger J. Parental report of eating problems and gastrointestinal symptoms in children with pervasive developmental disorders. Child Health Care. 2005;34(3):217–34.CrossRef Kerwin ME, Eicher PS, Gelsinger J. Parental report of eating problems and gastrointestinal symptoms in children with pervasive developmental disorders. Child Health Care. 2005;34(3):217–34.CrossRef
23.
Zurück zum Zitat Zickgraf HF, Richard E, Zucker NL, Wallace GL. Rigidity and Sensory Sensitivity: Independent Contributions to Selective Eating in Children, Adolescents, and Young Adults. J Clin Child Adolesc Psychol. 2022;51(5):675–87.PubMedCrossRef Zickgraf HF, Richard E, Zucker NL, Wallace GL. Rigidity and Sensory Sensitivity: Independent Contributions to Selective Eating in Children, Adolescents, and Young Adults. J Clin Child Adolesc Psychol. 2022;51(5):675–87.PubMedCrossRef
24.
Zurück zum Zitat Sharp WG, Postorino V, McCracken CE, Berry RC, Criado KK, Burrell TL, et al. Dietary Intake, Nutrient Status, and Growth Parameters in Children with Autism Spectrum Disorder and Severe Food Selectivity: An Electronic Medical Record Review. J Acad Nutr Diet. 2018;118(10):1943–50.PubMedCrossRef Sharp WG, Postorino V, McCracken CE, Berry RC, Criado KK, Burrell TL, et al. Dietary Intake, Nutrient Status, and Growth Parameters in Children with Autism Spectrum Disorder and Severe Food Selectivity: An Electronic Medical Record Review. J Acad Nutr Diet. 2018;118(10):1943–50.PubMedCrossRef
25.
Zurück zum Zitat Esteban-Figuerola P, Canals J, Fernández-Cao JC, Arija VV. Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis. Autism. 2019;23(5):1079–95.PubMedCrossRef Esteban-Figuerola P, Canals J, Fernández-Cao JC, Arija VV. Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis. Autism. 2019;23(5):1079–95.PubMedCrossRef
27.
Zurück zum Zitat Jane Y, Betsy P, Fengyi K. The Sensory Experience of Toilet Training and Its Implications for Autism Intervention. In: Michael F, editor. Recent Advances in Autism Spectrum Disorders. Rijeka: IntechOpen; 2013. p. Ch. 5 Jane Y, Betsy P, Fengyi K. The Sensory Experience of Toilet Training and Its Implications for Autism Intervention. In: Michael F, editor. Recent Advances in Autism Spectrum Disorders. Rijeka: IntechOpen; 2013. p. Ch. 5
28.
Zurück zum Zitat Little LM, Benton K, Manuel-Rubio M, Saps M, Fishbein M. Contribution of Sensory Processing to Chronic Constipation in Preschool Children. J Pediatr. 2019;210:141–5.PubMedCrossRef Little LM, Benton K, Manuel-Rubio M, Saps M, Fishbein M. Contribution of Sensory Processing to Chronic Constipation in Preschool Children. J Pediatr. 2019;210:141–5.PubMedCrossRef
29.
Zurück zum Zitat Ferguson BJ, Marler S, Altstein LL, Lee EB, Akers J, Sohl K, et al. Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder. Autism Res. 2017;10(2):276–88.PubMedCrossRef Ferguson BJ, Marler S, Altstein LL, Lee EB, Akers J, Sohl K, et al. Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder. Autism Res. 2017;10(2):276–88.PubMedCrossRef
30.
Zurück zum Zitat Craig SG, Weiss MD, Hudec KL, Gibbins C. The Functional Impact of Sleep Disorders in Children With ADHD. J Atten Disord. 2020;24(4):499–508.PubMedCrossRef Craig SG, Weiss MD, Hudec KL, Gibbins C. The Functional Impact of Sleep Disorders in Children With ADHD. J Atten Disord. 2020;24(4):499–508.PubMedCrossRef
31.
Zurück zum Zitat Canals J, Morales-Hidalgo P, Voltas N, Hernández-Martínez C. Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study. Autism Res. 2024;17(6):1276–86.PubMedCrossRef Canals J, Morales-Hidalgo P, Voltas N, Hernández-Martínez C. Prevalence of comorbidity of autism and ADHD and associated characteristics in school population: EPINED study. Autism Res. 2024;17(6):1276–86.PubMedCrossRef
32.
Zurück zum Zitat Rong Y, Yang C-J, Jin Y, Wang Y. Prevalence of attention-deficit/hyperactivity disorder in individuals with autism spectrum disorder: A meta-analysis. Res Autism Spectr Disord. 2021;83:101759.CrossRef Rong Y, Yang C-J, Jin Y, Wang Y. Prevalence of attention-deficit/hyperactivity disorder in individuals with autism spectrum disorder: A meta-analysis. Res Autism Spectr Disord. 2021;83:101759.CrossRef
33.
Zurück zum Zitat McKeown C, Hisle-Gorman E, Eide M, Gorman GH, Nylund CM. Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. Pediatrics. 2013;132(5):e1210–5.PubMedPubMedCentralCrossRef McKeown C, Hisle-Gorman E, Eide M, Gorman GH, Nylund CM. Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. Pediatrics. 2013;132(5):e1210–5.PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Aarts E, Ederveen THA, Naaijen J, Zwiers MP, Boekhorst J, Timmerman HM, et al. Gut microbiome in ADHD and its relation to neural reward anticipation. PLoS ONE. 2017;12(9):e0183509.PubMedPubMedCentralCrossRef Aarts E, Ederveen THA, Naaijen J, Zwiers MP, Boekhorst J, Timmerman HM, et al. Gut microbiome in ADHD and its relation to neural reward anticipation. PLoS ONE. 2017;12(9):e0183509.PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Ming X, Chen N, Ray C, Brewer G, Kornitzer J, Steer RA. A Gut Feeling: A Hypothesis of the Role of the Microbiome in Attention-Deficit/Hyperactivity Disorders. Child Neurol Open. 2018;5:2329048x18786799 Ming X, Chen N, Ray C, Brewer G, Kornitzer J, Steer RA. A Gut Feeling: A Hypothesis of the Role of the Microbiome in Attention-Deficit/Hyperactivity Disorders. Child Neurol Open. 2018;5:2329048x18786799
36.
Zurück zum Zitat Dellapiazza F, Michelon C, Vernhet C, Muratori F, Blanc N, Picot MC, et al. Sensory processing related to attention in children with ASD, ADHD, or typical development: results from the ELENA cohort. Eur Child Adolesc Psychiatry. 2021;30(2):283–91.PubMedCrossRef Dellapiazza F, Michelon C, Vernhet C, Muratori F, Blanc N, Picot MC, et al. Sensory processing related to attention in children with ASD, ADHD, or typical development: results from the ELENA cohort. Eur Child Adolesc Psychiatry. 2021;30(2):283–91.PubMedCrossRef
37.
Zurück zum Zitat Holmskov M, Storebø OJ, Moreira-Maia CR, Ramstad E, Magnusson FL, Krogh HB, et al. Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. PLoS ONE. 2017;12(6):e0178187.PubMedPubMedCentralCrossRef Holmskov M, Storebø OJ, Moreira-Maia CR, Ramstad E, Magnusson FL, Krogh HB, et al. Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials. PLoS ONE. 2017;12(6):e0178187.PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Pang L, Sareen R. Retrospective analysis of adverse events associated with non-stimulant ADHD medications reported to the united states food and drug administration. Psychiatry Res. 2021;300:113861.PubMedCrossRef Pang L, Sareen R. Retrospective analysis of adverse events associated with non-stimulant ADHD medications reported to the united states food and drug administration. Psychiatry Res. 2021;300:113861.PubMedCrossRef
39.
Zurück zum Zitat Kuizenga-Wessel S, Di Lorenzo C, Nicholson LM, Butter EM, Ratliff-Schaub KL, Benninga MA, et al. Screening for autism identifies behavioral disorders in children functional defecation disorders. Eur J Pediatr. 2016;175(10):1371–8.PubMedPubMedCentralCrossRef Kuizenga-Wessel S, Di Lorenzo C, Nicholson LM, Butter EM, Ratliff-Schaub KL, Benninga MA, et al. Screening for autism identifies behavioral disorders in children functional defecation disorders. Eur J Pediatr. 2016;175(10):1371–8.PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Marler S, Ferguson BJ, Lee EB, Peters B, Williams KC, McDonnell E, et al. Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder. J Autism Dev Disord. 2017;47(6):1673–81.PubMedPubMedCentralCrossRef Marler S, Ferguson BJ, Lee EB, Peters B, Williams KC, McDonnell E, et al. Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder. J Autism Dev Disord. 2017;47(6):1673–81.PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086–106.PubMedCrossRef Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086–106.PubMedCrossRef
42.
Zurück zum Zitat Esposito M, Mirizzi P, Fadda R, Pirollo C, Ricciardi O, Mazza M, et al. Food Selectivity in Children with Autism: Guidelines for Assessment and Clinical Interventions. Int J Environ Res Public Health. 2023;20(6) Esposito M, Mirizzi P, Fadda R, Pirollo C, Ricciardi O, Mazza M, et al. Food Selectivity in Children with Autism: Guidelines for Assessment and Clinical Interventions. Int J Environ Res Public Health. 2023;20(6)
43.
Zurück zum Zitat Vilanova-Sanchez A, Gasior AC, Toocheck N, Weaver L, Wood RJ, Reck CA, et al. Are Senna based laxatives safe when used as long term treatment for constipation in children? J Pediatr Surg. 2018;53(4):722–7.PubMedCrossRef Vilanova-Sanchez A, Gasior AC, Toocheck N, Weaver L, Wood RJ, Reck CA, et al. Are Senna based laxatives safe when used as long term treatment for constipation in children? J Pediatr Surg. 2018;53(4):722–7.PubMedCrossRef
44.
Zurück zum Zitat Wiggins LD, Nadler C, Hepburn S, Rosenberg S, Reynolds A, Zubler J. Toileting Resistance Among Preschool-Age Children with and Without Autism Spectrum Disorder. J Dev Behav Pediatr. 2022;43(4):216–23.PubMedPubMedCentralCrossRef Wiggins LD, Nadler C, Hepburn S, Rosenberg S, Reynolds A, Zubler J. Toileting Resistance Among Preschool-Age Children with and Without Autism Spectrum Disorder. J Dev Behav Pediatr. 2022;43(4):216–23.PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Heitmann PT, Vollebregt PF, Knowles CH, Lunniss PJ, Dinning PG, Scott SM. Understanding the physiology of human defaecation and disorders of continence and evacuation. Nat Rev Gastroenterol Hepatol. 2021;18(11):751–69.PubMedCrossRef Heitmann PT, Vollebregt PF, Knowles CH, Lunniss PJ, Dinning PG, Scott SM. Understanding the physiology of human defaecation and disorders of continence and evacuation. Nat Rev Gastroenterol Hepatol. 2021;18(11):751–69.PubMedCrossRef
46.
Zurück zum Zitat Ferguson BJ, Dovgan K, Takahashi N, Beversdorf DQ. The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents With Autism Spectrum Disorder. Front Psychiatry. 2019;10:194.PubMedPubMedCentralCrossRef Ferguson BJ, Dovgan K, Takahashi N, Beversdorf DQ. The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents With Autism Spectrum Disorder. Front Psychiatry. 2019;10:194.PubMedPubMedCentralCrossRef
47.
48.
Zurück zum Zitat Tabbers MM, Benninga MA. Constipation in children: fibre and probiotics. BMJ Clin Evid. 2015;2015 Tabbers MM, Benninga MA. Constipation in children: fibre and probiotics. BMJ Clin Evid. 2015;2015
49.
Zurück zum Zitat Waikar Y. High-resolution anorectal manometry in children. Clin Exp Pediatr. 2024;67(2):57–63.PubMedCrossRef Waikar Y. High-resolution anorectal manometry in children. Clin Exp Pediatr. 2024;67(2):57–63.PubMedCrossRef
50.
Zurück zum Zitat Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, et al. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019;54(11):2305–10.PubMedCrossRef Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, et al. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019;54(11):2305–10.PubMedCrossRef
51.
52.
Zurück zum Zitat Kanne SM, Bishop SL. Editorial Perspective: The autism waitlist crisis and remembering what families need. J Child Psychol Psychiatry. 2021;62(2):140–2.PubMedCrossRef Kanne SM, Bishop SL. Editorial Perspective: The autism waitlist crisis and remembering what families need. J Child Psychol Psychiatry. 2021;62(2):140–2.PubMedCrossRef
53.
Zurück zum Zitat Mandell DS, Morales KH, Xie M, Lawer LJ, Stahmer AC, Marcus SC. Age of diagnosis among Medicaid-enrolled children with autism, 2001–2004. Psychiatr Serv. 2010;61(8):822–9.PubMedPubMedCentralCrossRef Mandell DS, Morales KH, Xie M, Lawer LJ, Stahmer AC, Marcus SC. Age of diagnosis among Medicaid-enrolled children with autism, 2001–2004. Psychiatr Serv. 2010;61(8):822–9.PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Karpur A, Lello A, Frazier T, Dixon PJ, Shih AJ. Health Disparities among Children with Autism Spectrum Disorders: Analysis of the National Survey of Children’s Health 2016. J Autism Dev Disord. 2019;49(4):1652–64.PubMedCrossRef Karpur A, Lello A, Frazier T, Dixon PJ, Shih AJ. Health Disparities among Children with Autism Spectrum Disorders: Analysis of the National Survey of Children’s Health 2016. J Autism Dev Disord. 2019;49(4):1652–64.PubMedCrossRef
Metadaten
Titel
Constipation in Children with Autism: A Comprehensive Review
verfasst von
Ashish Chogle
Gregory Wong
J. Thomas Megerian
Publikationsdatum
03.09.2024
Verlag
Springer International Publishing
Erschienen in
Current Treatment Options in Pediatrics / Ausgabe 4/2024
Elektronische ISSN: 2198-6088
DOI
https://doi.org/10.1007/s40746-024-00304-6

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