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Journal of Natural Medicines
Erschienen in: Journal of Natural Medicines 1/2017

17.08.2016 | Note

Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production

verfasst von: Chongyue Qiu, Liang Tong, Ting Yuan, Fei Wang, Feng Zhao, Lixia Chen

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2017

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Abstract

An iridoid glucoside, 10-p-hydroxybenzoyl-6β-hydroxyiridoid 1-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (1), and a phenol glucoside, 4-hydroxyphenethanol 3-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (2), along with nine known compounds (3–11) were isolated from the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive analysis of NMR spectra. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in RAW 264.7 macrophages. Compounds 2 and 3 exhibited obvious inhibitory effects on NO production with IC50 values of 30.76 and 49.89 μM, respectively. Molecular docking studies of compounds 2 and 3 with nitric oxide synthase (NOS) further confirmed the above results.
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Metadaten
Titel
Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production
verfasst von
Chongyue Qiu
Liang Tong
Ting Yuan
Fei Wang
Feng Zhao
Lixia Chen
Publikationsdatum
17.08.2016
Verlag
Springer Japan
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-1032-y

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