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Erschienen in: Acta Neurologica Belgica 1/2017

26.09.2016 | Original Article

Contrast-associated transient cortical blindness: three cases with MRI and electrophysiology findings

verfasst von: Marius Baguma, Nadia Younan, Frédéric London, Michel Ossemann, Yves Vandermeeren

Erschienen in: Acta Neurologica Belgica | Ausgabe 1/2017

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Abstract

Transient cortical blindness (TCB) is a rare but striking complication following contrast agent injection. TCB might be secondary to a direct toxicity of the contrast agent, leading to an osmotic disruption of the blood–brain barrier (BBB), with a preferential involvement of the posterior circulation and occipital cortex. We report a series of three patients with contrast medium-associated TCB (intra-arterial injection of non-ionic contrast agent during diagnostic cerebral angiography for two of them and coronary angioplasty for the other one). In two patients, the magnetic resonance imaging (MRI) was unremarkable; in the other patient, typical MRI findings were observed, with FLAIR hyperintensities in the right occipital cortex and decreased apparent diffusions coefficient (ADC). Interestingly, this patient also presented posterior rhythmic epileptiform activities on electroencephalogram during the first 36 h. Visual evoked potentials (VEPs) showed normal retinal potential, but a massive destructuration of the later potentials of the cortical origin. To our knowledge, this is the first time that VEPs acquired during TCB are reported. We discuss these findings with respect to the pathophysiology of TCB.
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Metadaten
Titel
Contrast-associated transient cortical blindness: three cases with MRI and electrophysiology findings
verfasst von
Marius Baguma
Nadia Younan
Frédéric London
Michel Ossemann
Yves Vandermeeren
Publikationsdatum
26.09.2016
Verlag
Springer International Publishing
Erschienen in
Acta Neurologica Belgica / Ausgabe 1/2017
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-016-0696-0

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