Contrast-Enhanced Intraoperative Ultrasound Improved Sensitivity and Positive Predictive Value in Colorectal Liver Metastasis: a Systematic Review and Meta-Analysis
- 27.11.2020
- Colorectal Cancer
Erschienen in:
- Verfasst von
- Wei Liu, MD
- Zhong-Yi Zhang, MD
- Shan-Shan Yin, MD
- Kun Yan, MD
- Bao-Cai Xing, MD
- Erschienen in
- Annals of Surgical Oncology | Ausgabe 7/2021
Abstract
Background
The diagnostic accuracy of imaging modalities in colorectal cancer liver metastases (CRLM) has improved in recent years, therefore the role of current imaging techniques needs to be defined.
Objective
The aim of this study was to assess the diagnostic performance of magnetic resonance imaging, preoperative imaging (magnetic resonance imaging or computed tomography), intraoperative ultrasound, and contrast-enhanced intraoperative ultrasound in the detection of CRLM.
Materials and methods
Eligible trials published before 30 March 2020 were identified from the EMBASE, PubMed, Web of Science, and Cochrane Library databases, and descriptive and quantitative data were extracted. Study quality was evaluated for the identified studies and a random-effects model was used to determine the integrated diagnosis estimation. Meta-regression was implemented to explore the possible contributors to heterogeneity.
Results
Overall, 13 studies were included for analysis, comprising 682 patients with a total of 2303 liver lesions. The pooled sensitivity, specificity, and diagnostic odds ratio of contrast-enhanced intraoperative ultrasound were 0.94 (95% confidence interval [CI] 0.89–0.97), 0.83 (95% CI 0.67–0.92), and 79 (95% CI 32–196), respectively. The overall weighted area under the curve was 0.96 (95% CI 0.94–0.97). In univariate meta-regression analysis, disappearing liver metastasis, contrast agent, and Kupffer phase were the potent sources of heterogeneity; however, in multivariate meta-regression, no definite variable was the source of the study heterogeneity.
Conclusion
Contrast-enhanced intraoperative ultrasound demonstrated a high sensitivity and specificity for screening CRLM.
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- Titel
- Contrast-Enhanced Intraoperative Ultrasound Improved Sensitivity and Positive Predictive Value in Colorectal Liver Metastasis: a Systematic Review and Meta-Analysis
- Verfasst von
-
Wei Liu, MD
Zhong-Yi Zhang, MD
Shan-Shan Yin, MD
Kun Yan, MD
Bao-Cai Xing, MD
- Publikationsdatum
- 27.11.2020
- Verlag
- Springer International Publishing
- Erschienen in
-
Annals of Surgical Oncology / Ausgabe 7/2021
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681 - DOI
- https://doi.org/10.1245/s10434-020-09365-x
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