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European Radiology
Erschienen in:

14.08.2024 | Ultrasound

Contrast-enhanced US versus US-guided biopsy for abdominal and pelvic neoplasm in paediatric patients: a propensity score matching study

verfasst von: Ming Liu, Yingxin Liu, Wenying Zhou, Fushun Pan, Meixi Chen, Xiaoyan Xie, Luyao Zhou

Erschienen in: European Radiology | Ausgabe 2/2025

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Abstract

Objective

To compare the diagnostic performance of CEUS-guided biopsy (CEUS-GB) and ultrasound-guided biopsy (US-GB) in evaluating abdominal and pelvic (abdominopelvic) neoplasms in paediatric patients.

Methods

Patients aged < 18 years with abdominopelvic tumours who underwent either CEUS-GB or US-GB between April 2005 and May 2022 were retrospectively evaluated. Tumours diagnosed as malignancies by pathology were considered true-positive findings. Benign lesions were identified by pathology or clinical follow-up of at least 6 months. The diagnostic performance of the two groups was compared using propensity score matching (PSM). Complications were also analysed.

Results

The present study included 764 paediatric patients (437 boys; median age, 24 months; interquartile range, 10–60 months); 151 were in the CEUS-GB group, and 613 were in the US-GB group. The sample adequacy rate was 100% (151 of 151) for the CEUS-GB group, which was greater than the 97.4% (597 of 613) for the US-GB group (p < 0.001). The overall diagnostic accuracy of the CEUS-GB group and US-GB group was 98.7% (149 of 151) versus 97.3% (581 of 597) in the total cohort (p = 0.551) and 98.7% (149 of 151) versus 92.7% (140 of 151) in the PSM cohort (p = 0.020). Two patients (0.3%) in the US-GB group experienced complications (Common Terminology Criteria for Adverse Events (CTCAE), grade 1–2) correlated with the biopsy. No adverse reactions occurred in the CEUS-GB group.

Conclusion

CEUS-GB of abdominopelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-GB, especially for tumours with necrotic areas.

Clinical relevance statement

Contrast-enhanced US-guided biopsy of solid abdominal and pelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-guided biopsy, especially for tumours with necrotic areas.

Key Points

  • Contrast-enhanced ultrasound (CEUS) may be superior to conventional ultrasound at guiding biopsy of abdominopelvic masses in paediatric patients.
  • CEUS-guided core needle biopsy of abdominopelvic masses in children was safe and resulted in a diagnostic yield of 98.7%.
  • CEUS guidance should be considered in this population when colour Doppler US is unable to determine a biopsy site.
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Metadaten
Titel
Contrast-enhanced US versus US-guided biopsy for abdominal and pelvic neoplasm in paediatric patients: a propensity score matching study
verfasst von
Ming Liu
Yingxin Liu
Wenying Zhou
Fushun Pan
Meixi Chen
Xiaoyan Xie
Luyao Zhou
Publikationsdatum
14.08.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2025
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-024-11018-6

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