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01.04.2015 | Research Article | Ausgabe 4/2015

Tumor Biology 4/2015

Contribution of susceptibility locus at HLA class I region and environmental factors to occurrence of nasopharyngeal cancer in Northeast India

Zeitschrift:
Tumor Biology > Ausgabe 4/2015
Autoren:
Meena Lakhanpal, Laishram Chandreshwor Singh, Tashnin Rahman, Jagnnath Sharma, M. Madhumangal Singh, Amal Chandra Kataki, Saurabh Verma, Pradeep Singh Chauhan, Y. Mohan Singh, Saima Wajid, Sujala Kapur, Sunita Saxena
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s13277-014-2942-5) contains supplementary material, which is available to authorized users.

Abstract

High incidence of nasopharyngeal carcinoma (NPC) has been reported from China, Southeast Asia and Northeast (NE) region of India. Populations at geographic regions having higher incidence of NPC display human leukocyte antigen (HLA) distribution patterns different from areas having low incidence. The current study has investigated the contribution of environmental risk factors and ethnic variation of microsatellite markers in HLA region for the high incidence of NPC in NE India. Genotyping of HLA region using 33 microsatellite markers by fragment length analysis was done in 220 study subjects (120 NPC patients and 100 healthy controls). Association analysis showed two adjacent microsatellite markers HL003 (allele 121) and D6S2704 (allele 218) in the HLA class I region having association with high risk of NPC while allele 127 of HL003 and allele 255 of D6S2678 conferred a protective effect. The environmental factors mainly use of firewood (odds ratio (OR) = 3.797385, confidence interval (CI) = 1.97–7.30, P < 0), living in mud house (OR = 3.46, CI = 1.19–10.08, P = 0.022) and consumption of alcohol (OR = 2.11, CI = 1.02–4.37, P = 0.043) were found as major risk factors for NPC. Higher-order interaction showed combination of smoked food consumption and firewood use for cooking in multifactor dimensionality reduction (MDR) analysis and interaction of non-firewood users, non-ventilated houses and residence in mud houses in classification and regression tree (CART) analysis as the significant risk factors for NPC. Expression of Epstein–Barr virus (EBV) RNA was found in 92 % (23/25) of NPC cases suggesting its significant role in NPC aetiopathogenesis. This study identified association of NPC with a susceptibility locus in the HLA class I region which has complex interaction with viral DNA and environmental factors.

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Zusatzmaterial
Supplementary Fig. 1 (PDF 508 kb)
13277_2014_2942_MOESM1_ESM.pdf
Supplementary Fig. 2 (PDF 923 kb)
13277_2014_2942_MOESM2_ESM.pdf
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