nach oben

Digestive Diseases and Sciences

Erschienen in:

21.08.2019 | PARADIGM SHIFTS IN PERSPECTIVE

Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too

verfasst von: Jonathan D. Kaunitz, Yasutada Akiba

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2019

Einloggen, um Zugang zu erhalten

Excerpt

“A story has no beginning or end: arbitrarily one chooses that moment of experience from which to look back or from which to look ahead.”

― Graham Greene, The End of the Affair

…

Mah AT, Kuo CJ. Home sweet home: a Foxl1(+) mesenchymal niche for intestinal stem cells. Cell Mol Gastroenterol Hepatol. 2016;2:116–117.PubMedPubMedCentral

Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol. 2009;174:715–721.PubMedPubMedCentral

McCabe LR, Parameswaran N. Recent advances in intestinal stem cells. Curr Mol Biol Rep. 2017;3:143–148.PubMedPubMedCentral

Yen TH, Wright NA. The gastrointestinal tract stem cell niche. Stem Cell Rev. 2006;2:203–212.PubMed

Mao SA, Glorioso JM, Nyberg SL. Liver regeneration. Transl Res. 2014;163:352–362.PubMedPubMedCentral

Whitall JDIX. Extensive removals of intestine: report of a case of recovery after resection of ten feet eight inches of the ileum. Ann Surg. 1911;54:669–672.PubMedPubMedCentral

Althausen TL, Doig RK, Uyeyama K, et al. Digestion and absorption after massive resection of the small intestine. II. Recovery of the absorptive function as shown by intestinal absorption tests in two patients and a consideration of compensatory mechanisms. Gastroenterology. 1950;16:126–139.PubMed

Clatworthy HW Jr, Saleeby R, Lovingood C. Extensive small bowel resection in young dogs; its effect on growth and development; an experimental study. Surgery. 1952;32:341–351.PubMed

Weser E. Intestinal adaptation to small bowel resection. Am J Clin Nutr. 1971;24:133–135.PubMed

10.

Loran MR, Crocker TT. Population dynamics of intestinal epithelia in the rat two months after partial resection of the ileum. J Cell Biol. 1963;19:285–291.PubMedPubMedCentral

11.

Sutherland Ead C. Origin and distribution of hyperglycemic-glycogenolytic factor of the pancreas. J Biol Chem. 1948;175:663–674.

12.

Makman MH, Sutherland EW. Use of liver adenyl cyclase for assay of glucagon in human gastro-intestinal tract and pancreas. Endocrinology. 1964;75:127–134.PubMed

13.

Makman MH, Makman RS, Sutherland EW. Presence of a glucagon-like material in blood of man and dog. J Biol Chem. 1958;233:894–899.PubMed

14.

Unger RH, Ketterer H, Eisentraut AM. Distribution of immunoassayable glucagon in gastrointestinal tissues. Metabolism. 1966;15:865–867.PubMed

15.

Bloom SR, Polak JM. The hormonal pattern of intestinal adaptation. A major role for enteroglucagon. Scand J Gastroenterol Suppl. 1982;74:93–103.PubMed

16.

Gleeson MH, Bloom SR, Polak JM, et al. An endocrine tumour in kidney affecting small bowel structure, motility, and function. Gut. 1970;11:1060.PubMed

17.

Dowling RH. Glucagon-like peptide-2 and intestinal adaptation: an historical and clinical perspective. J Nutr. 2003;133:3703–3707.PubMed

18.

Orskov C, Holst JJ, Knuhtsen S, et al. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology. 1986;119:1467–1475.PubMed

19.

Drucker DJ, Erlich P, Asa SL, et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996;93:7911–7916.PubMedPubMedCentral

20.

Helander HF, Fandriks L. The enteroendocrine “letter cells”—time for a new nomenclature? Scand J Gastroenterol. 2012;47:3–12.PubMed

21.

Addis T. Hypertrophy of the gastro-intestinal tract and high residue diets. Am J Physiol. 1932;99:417–423.

22.

Jacobs LR. Effects of dietary fiber on mucosal growth and cell proliferation in the small intestine of the rat: a comparison of oat bran, pectin, and guar with total fiber deprivation. Am J Clin Nutr. 1983;37:954–960.PubMed

23.

Shaw D, Gohil K, Basson MD. Intestinal mucosal atrophy and adaptation. World J Gastroenterol. 2012;18:6357–6375.PubMedPubMedCentral

24.

Sakata T, Von EW. Stimulatory effect of short chain fatty acids on the epithelial cell proliferation in rat large intestine. Comp Biochem Physiol A Comp Physiol. 1983;74:459–462.PubMed

25.

Tonelli F, Dolara P, Batignani G, et al. Effects of short chain fatty acids on mucosal proliferation and inflammation of ileal pouches in patients with ulcerative colitis and familial polyposis. Dis Colon Rectum. 1995;38:974–978.PubMed

26.

Tappenden KA, Albin DM, Bartholome AL, et al. Glucagon-like peptide-2 and short-chain fatty acids: a new twist to an old story. J Nutr. 2003;133:3717–3720.PubMed

27.

Said H, Akiba Y, Narimatsu K, et al. FFA3 activation stimulates duodenal bicarbonate secretion and prevents NSAID-induced enteropathy via the GLP-2 pathway in rats. Dig Dis Sci. 2017;62:1944–1952. https://doi.org/10.1007/s10620-017-4600-4.CrossRefPubMedPubMedCentral

28.

Kaji I, Karaki S, Kuwahara A. Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release. Digestion. 2014;89:31–36.PubMed

29.

Grobstein C. Inductive epitheliomesenchymal interaction in cultured organ rudiments of the mouse. Science. 1953;118:52–55.PubMed

30.

Okada TS. Epithelio-mesenchymal relationships in the regional differentiation of the digestive tract in the amphibian embryo. Wilhelm Roux Arch Entwickl Mech Org. 1960;152:1–21.PubMed

31.

Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, et al. Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature. 2018;557:242–246.PubMedPubMedCentral

32.

Feng R, Aihara E, Kenny S, et al. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014;147(655–666):e9.

33.

Kurahashi M, Nakano Y, Peri LE, et al. A novel population of subepithelial platelet-derived growth factor receptor alpha-positive cells in the mouse and human colon. Am J Physiol Gastrointest Liver Physiol. 2013;304:G823–G834.PubMedPubMedCentral

34.

Orskov C, Hartmann B, Poulsen SS, et al. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regul Pept. 2005;124:105–112.PubMed

35.

Furuya S, Furuya K. Subepithelial fibroblasts in intestinal villi: roles in intercellular communication. Int Rev Cytol. 2007;264:165–223.PubMed

36.

Powell DW, Mifflin RC, Valentich JD, et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol. 1999;277:C1–C9.PubMed

37.

Roulis M, Flavell RA. Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease. Differentiation. 2016;92:116–131.PubMed

38.

Powell DW, Pinchuk IV, Saada JI, et al. Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol. 2011;73:213–237.PubMedPubMedCentral

39.

Hosoyamada Y, Sakai T. Structural and mechanical architecture of the intestinal villi and crypts in the rat intestine: integrative reevaluation from ultrastructural analysis. Anat Embryol (Berl). 2005;210:1–12.

40.

Marsh MN, Trier JS. Morphology and cell proliferation of subepithelial fibroblasts in adult mouse jejunum. I. Structural features. Gastroenterology. 1974;67:622–635.PubMed

41.

Kaye GI, Lane N, Pascal RR. Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon. Gastroenterology. 1968;54:852–865.PubMed

42.

Eyden B, Curry A, Wang G. Stromal cells in the human gut show ultrastructural features of fibroblasts and smooth muscle cells but not myofibroblasts. J Cell Mol Med. 2011;15:1483–1491.PubMed

43.

Furuya S, Furuya K. Roles of substance P and ATP in the subepithelial fibroblasts of rat intestinal villi. Int Rev Cell Mol Biol. 2013;304:133–189.PubMed

44.

Desaki J, Shimizu M. A re-examination of the cellular reticulum of fibroblast-like cells in the rat small intestine by scanning electron microscopy. J Electron Microsc (Tokyo). 2000;49:203–208.

45.

Desaki J, Fujiwara T, Komuro T. A cellular reticulum of fibroblast-like cells in the rat intestine: scanning and transmission electron microscopy. Arch Histol Jpn. 1984;47:179–186.PubMed

46.

Deane HW. Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells and eosinophils. Anat Rec. 1964;149:453–473.PubMed

47.

Takahashi-Iwanaga H, Fujita T. Lamina propria of intestinal mucosa as a typical reticular tissue. A scanning electron-microscopic study of the rat jejunum. Cell Tissue Res. 1985;242:57–66.PubMed

48.

Toyoda H, Ina K, Kitamura H, et al. Organization of the lamina propria mucosae of rat intestinal mucosa, with special reference to the subepithelial connective tissue. Acta Anat (Basel). 1997;158:172–184.

49.

Komuro T, Hashimoto Y. Three-dimensional structure of the rat intestinal wall (mucosa and submucosa). Arch Histol Cytol. 1990;53:1–21.PubMed

50.

Popescu LM, Faussone-Pellegrini MS. TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES. J Cell Mol Med. Volume 14. England, 2010:729-40.

51.

Greicius G, Kabiri Z, Sigmundsson K, et al. PDGFRalpha(+) pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proc Natl Acad Sci U S A. 2018;115:e3173–e3181.PubMedPubMedCentral

52.

El Maadawi ZM. A tale of two cells: telocyte and stem cell unique relationship. Adv Exp Med Biol. 2016;913:359–376.PubMed

53.

Marini M, Ibba-Manneschi L, Manetti M. Cardiac telocyte-derived exosomes and their possible implications in cardiovascular pathophysiology. Adv Exp Med Biol. 2017;998:237–254.PubMed

54.

Diaz-Flores L, Gutierrez R, Garcia MP, et al. Human resident CD34+ stromal cells/telocytes have progenitor capacity and are a source of alphaSMA+ cells during repair. Histol Histopathol. 2015;30:615–627.PubMed

55.

Yusta B, Huang L, Munroe D, et al. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology. 2000;119:744–755.PubMed

56.

Rowland KJ, Brubaker PL. The “cryptic” mechanism of action of glucagon-like peptide-2. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1–G8.PubMed

57.

Parker FG, Barnes EN, Kaye GI. The pericryptal fibroblast sheath. IV. Replication, migration, and differentiation of the subepithelial fibroblasts of the crypt and villus of the rabbit jejunum. Gastroenterology. 1974;67:607–621.PubMed

58.

Marsh MN, Trier JS. Morphology and cell proliferation of subepithelial fibroblasts in adult mouse jejunum. II. Radioautographic studies. Gastroenterology. 1974;67:636–645.PubMed

59.

Brittan M, Hunt T, Jeffery R, et al. Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut. 2002;50:752–757.PubMedPubMedCentral

60.

Neal JV, Potten CS. Description and basic cell kinetics of the murine pericryptal fibroblast sheath. Gut. 1981;22:19–24.PubMedPubMedCentral

61.

Pinchuk I, Powell D. Immunosuppression by intestinal stem cells. Adv Exp Med Biol. 2018; 1060.

62.

Austin K, Imam NA, Pintar JE, et al. IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine. Endocrinology. 2015;156:429–436.PubMed

63.

Nelson DW, Murali SG, Liu X, et al. Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats. Am J Physiol Regul Integr Comp Physiol 2008;294:R1175-R1184.PubMed

64.

Wiren M, Adrian TE, Arnelo U, et al. An increase in mucosal insulin-like growth factor II content in postresectional rat intestine suggests autocrine or paracrine growth stimulation. Scand J Gastroenterol. 1998;33:1080–1086.PubMed

65.

Aoki R, Shoshkes-Carmel M, Gao N, et al. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell Mol Gastroenterol Hepatol. 2016;2:175–188.PubMed

66.

Lei NY, Jabaji Z, Wang J, et al. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells. PLoS One. 2014;9:e84651.PubMedPubMedCentral

67.

Yan KS, Janda CY, Chang J, et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5. Nature. 2017;545:238–242.PubMedPubMedCentral

68.

Foulke-Abel J, In J, Yin J, et al. Human enteroids as a model of upper small intestinal ion transport physiology and pathophysiology. Gastroenterology 2016;150:638-649.PubMed

69.

Leen JL, Izzo A, Upadhyay C, et al. Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology. 2011;152:436–446.PubMed

70.

Bulut K, Pennartz C, Felderbauer P, et al. Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Eur J Pharmacol. 2008;578:279–285.PubMed

71.

Cinci L, Faussone-Pellegrini MS, Rotondo A, et al. GLP-2 receptor expression in excitatory and inhibitory enteric neurons and its role in mouse duodenum contractility. Neurogastroenterol Motil. 2011;23:e383–e392.PubMed

72.

Nelson DW, Sharp JW, Brownfield MS, et al. Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat. Endocrinology. 2007;148:1954–1962.PubMed

73.

Drucker DJ, Yusta B. Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2. Annu Rev Physiol. 2014;76:561–583.PubMed

74.

Kaji I, Akiba Y, Kaunitz JD. Digestive physiology of the pig symposium: involvement of gut chemosensing in the regulation of mucosal barrier function and defense mechanisms. J Anim Sci. 2013;91:1957–1962.PubMedPubMedCentral

75.

Sigalet DL, Wallace L, de HE, et al. The effects of glucagon-like peptide 2 on enteric neurons in intestinal inflammation. Neurogastroenterol Motil. 2010;22:1318.PubMed

76.

Amato A, Baldassano S, Serio R, et al. Glucagon-like peptide-2 relaxes mouse stomach through vasoactive intestinal peptide release. Am J Physiol Gastrointest Liver Physiol. 2009;296:G678–G684.PubMed

77.

Yusta B, Holland D, Waschek JA, Drucker DJ. Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice. Endocrinology. 2012;153:2623–2632.PubMedPubMedCentral

78.

Hapangama DK, Kamal AM, Bulmer JN. Estrogen receptor β: the guardian of the endometrium. Hum Reprod Update. 2015;21:174–193.PubMed

79.

Inui S, Itami S. Androgen actions on the human hair follicle: perspectives. Exp Dermatol. 2013;22:168–171.PubMed

80.

Bei Y, Wang F, Yang C, et al. Telocytes in regenerative medicine. J Cell Mol Med. 2015;19:1441–1454.PubMedPubMedCentral

81.

Vipperla K, O’Keefe SJ. Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects. Expert Rev Gastroenterol Hepatol. 2013;7:683–687.PubMed

82.

Jeppesen PB, Pertkiewicz M, Messing B, et al. Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology. 2012;143:1473–1481.PubMed

83.

Jeppesen PB. The long road to the development of effective therapies for the short gut syndrome: a personal perspective. Dig Dis Sci. 2019. https://doi.org/10.1007/s10620-019-05779-0.CrossRefPubMed

Titel: Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too
verfasst von: Jonathan D. Kaunitz
Yasutada Akiba
Publikationsdatum: 21.08.2019
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 10/2019
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-019-05778-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too

Excerpt

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2019

DDS Profile: Sonia Friedman, MD

EndoClot®SIS Polysaccharide Injection as a Submucosal Fluid Cushion for Endoscopic Mucosal Therapies: Results of Ex Vivo and In Vivo Studies

Low Sensitivity of Fecal Immunochemical Tests (FIT) for Detection of Sessile Serrated Adenomas/Polyps Confirmed Over Clinical Setting, Geography, and FIT System

Early Hepatitis B Surface Antigen Seroclearance Following Antiviral Treatment in Patients with Reactivation of Resolved Hepatitis B

miR-9-5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3

Obesity and the Risk of Gastrointestinal Cancers

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin