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Surgery Today
Erschienen in: Surgery Today 11/2019

04.04.2019 | Review Article

Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues

verfasst von: Hideyuki Yoshitomi, Shigetsugu Takano, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masayuki Ohtsuka

Erschienen in: Surgery Today | Ausgabe 11/2019

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Abstract

Pancreatic cancer is one of the most lethal of all malignancies. One of the reasons for the dismal prognosis is that most diagnoses are made when the disease is either locally advanced or metastatic. Recent advances in chemotherapy and chemoradiotherapy (CRT) enable “conversion surgery” to be performed for selected patients with initially unresectable pancreatic cancer following favorable responses to preoperative treatment. Using FOLFIRINOX as preoperative treatment, the resection rate was reported as 6–44% of patients with locally advanced cancer and the prognosis of these patients was favorable. Even for metastasized cancer, recent reports show the effectiveness of conversion surgery, which has achieved 27–56 months of median overall survival. However, there are many unanswered questions about conversion surgery. The optimal regimen and duration of preoperative treatment remain unclear and there is still debate regarding the safety and effectiveness of vascular resection, which is often required for curative resection of locally advanced cancer. Accumulation of more data on conversion surgery is required to establish the safety and effectiveness of this treatment. In this review, we summarize the current status and unresolved issues about conversion surgery for initially unresectable pancreatic cancer.
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Metadaten
Titel
Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues
verfasst von
Hideyuki Yoshitomi
Shigetsugu Takano
Katsunori Furukawa
Tsukasa Takayashiki
Satoshi Kuboki
Masayuki Ohtsuka
Publikationsdatum
04.04.2019
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 11/2019
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-019-01804-x

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