Coordinated role of RIG-I, MDA5, and TLR7 in the innate immune response to duck hepatitis A virus 3
- 01.10.2025
- Brief Report
Erschienen in:
- Verfasst von
- Duo Peng
- Xiaoyang Hu
- Jingjing Huang
- Qiong Li
- Yinuo Song
- Dabing Zhang
- Erschienen in
- Archives of Virology | Ausgabe 10/2025
Abstract
The roles of RIG-I, MDA5, and TLR7 in duck hepatitis A virus genotype 3 (DHAV-3) infection were investigated using duck embryo fibroblasts (DEFs). DHAV-3 infection induced significant upregulation of RIG-I, MDA5, and TLR7 and high IFN-β, IL-6, and OASL responses. Overexpression and knockdown of RIG-I, MDA5, and TLR7 exerted significant effects on DHAV-3-induced IFN-β, IL-6, and OASL expression and DHAV-3 replication. Overexpression and inhibition of TLR7 altered DHAV-3-induced RIG-I and MDA5 expression. Together, these findings suggest that TLR7 and RIG-I/MDA5 play a coordinated role in detection and initiation of innate immunity against DHAV-3 infection.
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- Titel
- Coordinated role of RIG-I, MDA5, and TLR7 in the innate immune response to duck hepatitis A virus 3
- Verfasst von
-
Duo Peng
Xiaoyang Hu
Jingjing Huang
Qiong Li
Yinuo Song
Dabing Zhang
- Publikationsdatum
- 01.10.2025
- Verlag
- Springer Vienna
- Erschienen in
-
Archives of Virology / Ausgabe 10/2025
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798 - DOI
- https://doi.org/10.1007/s00705-025-06384-5
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