Background
Methods
Study design
Setting
Participants
Variables
Statistical methods
Results
Patient baseline demographics
Main results
Start day of stimulation on day 2 or 3 of menses
Corifollitropin alfa | rFSH | |||
---|---|---|---|---|
Day 2 | Day 3 | Day 2 | Day 3 | |
n = 343 | n = 368 | n = 353 | n = 364 | |
Duration of stimulation, days, mean (SD)
| 9.8 (1.4) | 9.4 (1.5) | 9.4 (1.2) | 9.0 (1.3) |
Follicles on day 8 ≥11 mm, mean (SD)
| 12.0 (6.1) | 13.4 (6.4) | 11.4 (5.7) | 11.4 (5.8) |
Serum E
2
on day 8, pmol/l, median (P5, P95)
| 2562 | 3285 | 2743 | 3274 |
(837, 7524) | (840, 8918) | (987, 7487) | (1068, 8184) | |
Follicles on day of hCG ≥11 mm, mean (SD)
| 15.6 (6.5) | 16.1 (6.9) | 14.1 (6.0) | 13.3 (5.8) |
E
2
on day of hCG, pmol/l, median (P5, P95)
| 4239 | 4899 | 4110 | 4808 |
(1512, 11,891) | (1762, 11,671) | (1501, 9762) | (1740, 10,129) | |
No. of oocytes retrieved, mean (SD)
| 14.1 (8.1) | 14.0 (7.9) | 12.8 (6.6) | 12.4 (6.5) |
No. of embryos obtained on day 3, mean (SD)
| 8.2 (5.6) | 8.3 (5.4) | 7.5 (4.8) | 7.4 (4.6) |
No. of GQEs obtained on day 3, mean (SD)
| 4.5 (4.2) | 4.6 (4.4) | 4.4 (3.8) | 4.4 (3.8) |
No. of GQEs transferred, mean (SD)
| 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) | 1.4 (0.8) |
Cycle cancellation rate, n (%)
| 24 (7.0) | 34 (9.2) | 19 (5.4) | 17 (4.7) |
Factors included in model | Categories | Model 1* | Model 2† |
---|---|---|---|
Δ (95% CI) | Δ (95% CI) | ||
Start treatment
| Day 2 versus day 3 | -4.3 (-9.4, 0.8) | |
hCG delay
| No delay versus 1-day delay | 1.8 (-4.1, 7.6) | |
rFSH on day of hCG
| Yes versus no | 3.2 (-2.1, 8.6) | |
rFSH from day 8
| Step-down versus fixed dose | -5.8 (-13.0, 1.4) | |
Treatment group
| Corifollitropin alfa versus rFSH | 1.1 (-4.0, 6.2) | 1.1 (-4.8, 6.9) |
Age
| Per year increase | -1.1 (-1.9, -0.3) | -0.9 (-1.8, 0.0) |
Region
| North America versus Europe | 15.5 (10.2, 20.7) | 12.6 (6.8, 18.5) |
hCG administered on the day the hCG criterion was reached or 1 day later
Corifollitropin alfa | rFSH | |||
---|---|---|---|---|
No delay | Delay | No delay | Delay | |
n = 492 | n = 188 | n = 516 | n = 191 | |
Duration of stimulation, days, mean (SD)
| 9.4 (1.4) | 9.9 (1.3) | 9.1 (1.3) | 9.5 (1.0) |
Follicles on day 8 ≥11 mm, mean (SD)
| 12.8 (6.6) | 12.8 (5.5) | 11.4 (5.9) | 11.5 (5.1) |
Serum E
2
on day 8, pmol/l, median (P5, P95)
| 3019 | 2753 | 2965 | 3097 |
(837, 8588) | (1013, 7634) | (1017, 8184) | (1046, 7450) | |
Follicles on day of hCG ≥11 mm, mean (SD)
| 16.0 (6.9) | 15.6 (5.5) | 13.8 (6.2) | 13.6 (5.0) |
E
2
on day of hCG, pmol/l, median (P5, P95)
| 4551 | 4881 | 4477 | 4331 |
(1629, 11,450) | (1883, 11,964) | (1718, 9872) | (1758, 10,349) | |
No. of oocytes retrieved, mean (SD)
| 14.2 (8.3) | 14.1 (6.7) | 12.4 (6.6) | 13.3 (6.3) |
No. of embryos obtained on day 3, mean (SD)
| 8.1 (5.7) | 8.9 (4.9) | 7.4 (4.7) | 7.8 (4.5) |
No. of GQEs obtained on day 3, mean (SD)
| 4.4 (4.3) | 5.4 (4.2) | 4.3 (3.7) | 4.8 (3.9) |
No. of GQEs transferred, mean (SD)
| 1.2 (0.8) | 1.4 (0.7) | 1.3 (0.8) | 1.3 (0.8) |
Cycle cancellation rate, n (%)
| 45 (9.1) | 10 (5.3) | 23 (4.5) | 10 (5.2) |
rFSH on the day of hCG administration or not
Corifollitropin alfa | rFSH | |||
---|---|---|---|---|
No | Yes | No | Yes | |
n = 247 | n = 469 | n = 255 | n = 466 | |
Duration of stimulation, days, mean (SD)
| 9.6 (1.3) | 9.6 (1.5) | 9.3 (1.3) | 9.1 (1.2) |
Follicles on day 8 ≥11 mm, mean (SD)
| 13.4 (6.0) | 12.3 (6.5) | 11.1 (5.1) | 11.5 (6.0) |
Serum E
2
on day 8, pmol/l, median (P5, P95)
| 3382 | 2697 | 3075 | 2938 |
(1039, 8441) | (793, 8147) | (1057, 9432) | (995, 7854) | |
Follicles on day of hCG ≥11 mm, mean (SD)
| 16.7 (6.5) | 15.3 (6.7) | 13.6 (5.7) | 13.8 (6.1) |
E
2
on day of hCG, pmol/l, median (P5, P95)
| 5468 | 4221 | 4514 | 4331 |
(1982, 12,038) | (1497, 11,120) | (1736, 10,349) | (1600, 9799) | |
No. of oocytes retrieved, mean (SD)
| 14.8 (8.1) | 13.6 (7.8) | 12.4 (6.2) | 12.7 (6.7) |
No. of embryos obtained on day 3, mean (SD)
| 8.5 (5.4) | 8.1 (5.5) | 7.3 (4.4) | 7.5 (4.8) |
No. of GQEs obtained on day 3, mean (SD)
| 4.7 (4.1) | 4.5 (4.4) | 4.4 (3.5) | 4.4 (3.9) |
No. of GQEs transferred, mean (SD)
| 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) | 1.3 (0.7) |
Cycle cancellation rate, n (%)
| 22 (8.9) | 36 (7.7) | 12 (4.7) | 24 (5.2) |
Step-down or fixed-dose rFSH
Corifollitropin alfa | rFSH | |||
---|---|---|---|---|
Step-down | Fixed dose | Step-down | Fixed dose | |
n = 138 | n = 409 | n = 79 | n = 430 | |
Duration of stimulation, days, mean (SD)
| 10.0 (1.1) | 10.1 (1.3) | 9.8 (1.1) | 9.8 (1.0) |
Follicles on day 8 ≥11 mm, mean (SD)
| 15.2 (5.1) | 10.5 (5.4) | 14.1 (5.3) | 9.6 (4.7) |
E
2
on day 8, pmol/l, median (P5, P95)
| 4734 | 2341 | 4184 | 2415 |
(1431, 8918) | (738, 6019) | (995, 10,606) | (910, 6276) | |
Follicles on day of hCG ≥11 mm, mean (SD)
| 20.5 (5.3) | 14.1 (6.2) | 18.0 (6.1) | 12.6 (5.3) |
Serum E
2
on day of hCG, pmol/l, median (P5, P95)
| 7817 | 4147 | 7212 | 4221 |
(2393, 13,799) | (1497, 10,239) | (1655, 16,772) | (1696, 9726) | |
No. of oocytes retrieved, mean (SD)
| 19.4 (8.1) | 12.4 (7.4) | 16.5 (6.4) | 11.8 (6.4) |
No. of embryos obtained on day 3, mean (SD)
| 11.8 (6.0) | 7.5 (5.2) | 10.2 (5.2) | 7.1 (4.5) |
No. of GQEs obtained on day 3, mean (SD)
| 6.5 (5.7) | 4.1 (3.8) | 5.5 (4.4) | 4.3 (3.7) |
No. of GQEs transferred, mean (SD)
| 1.1 (0.8) | 1.3 (0.8) | 1.3 (0.7) | 1.3 (0.8) |
Cycle cancellation rate, n (%)
| 15 (10.9) | 30 (7.3) | 4 (5.1) | 23 (5.3) |