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01.11.2011 | Basic Science | Ausgabe 11/2011

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2011

Corneal intrastromal tissue modeling with the femtosecond laser

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 11/2011
Autoren:
Christian Meltendorf, Thomas Deller, Hanns Ackermann, Ulrich von Pape
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00417-011-1701-1) contains supplementary material, which is available to authorized users.
Dr. von Pape is a former employee of an involved company.

Abstract

Purpose

To determine whether central corneal thinning and flattening can be achieved by intrastromal photodisruption using a femtosecond (fs) laser.

Setting

Institute of Clinical Neuroanatomy, Goethe-University, Frankfurt am Main, Germany.

Methods

Fourteen horizontal, parallel intrastromal cuts were performed on rabbit eyes using a fs laser. Full-grown rabbits (group 1; ten eyes) received bilateral treatment. Growing rabbits (group 2) received unilateral treatment (four eyes). Slit-lamp examination, pachymetry, and keratometry were performed on day 9, 31 and 86 (group 1) or on day 12, 29, 69, 176 and 318 (group 2) after surgery.

Results

Nine days after treatment, corneal swelling was present and a slight increase of mean corneal thickness (group 1: +4.40 ± 5.56 μm) as well as a steeper mean corneal curvature (group 1: −0.18 ± 0.02 mm) were observed. In contrast, 1 month after tissue photodisruption corneas showed an average decrease of thickness (group 2: −21.0 ± 2.5 μm). By 6 months post-treatment, a further decrease (group 2: −36.3 ± 6.9 μm) was seen that remained stable for the rest of the observation period. At 176 days post-treatment, a decrease of corneal curvature (group 2: −0.21 ± 0.10 mm) was found. Slit-lamp examination revealed a transparent cornea. At the site of intrastromal photodisruption a narrow band of increased reflectivity could be detected.

Conclusions

Corneal thinning can be reliably achieved using intrastromal tissue modeling with a fs laser. Tissue modeling was accompanied by a transient opacity and irregularity of the corneal surface.

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