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Erschienen in: Journal of General Internal Medicine 2/2020

05.12.2019 | Original Research

Coronary Artery Disease and Atherosclerotic Risk Factors in a Population-Based Study of Sudden Death

verfasst von: Golsa Joodi, MD, MPH, Joan A. Maradey, MD, Brittany Bogle, PhD, MPH, Mojtaba Mirzaei, MD, MPH, Murrium I. Sadaf, MD, Irion Pursell, RN, BSN, Cory Henderson, MD, John Paul Mounsey, BM BCh, PhD, Ross J. Simpson Jr, MD, PhD

Erschienen in: Journal of General Internal Medicine | Ausgabe 2/2020

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Abstract

Background

Sudden death is a public health problem with major impact on society. Coronary artery disease (CAD) is believed to underlie 60–80% of these deaths. While deaths from CAD have decreased in the recent decades, sudden death rates remain unacceptably high.

Objective

We aimed to assess the prevalence of CAD and its risk factors among 18–64-year-old adults in a population-based case registry of sudden deaths and compare them to a living population from the same geographical area.

Design

From 2013 to 2015, all sudden deaths among 18–64-year-old adults in Wake County, NC, were identified (n = 371). A comparison group was formed by randomly selecting individuals from an electronic health record repository of a major healthcare system in the area (N = 4218).

Main Measures

Prevalence of CAD and its risk factors among cases of sudden death and living population across sex and age groups. Odds of sudden death associated with atherosclerotic risk factors and comorbidities.

Key Results

CAD was present in 14.8% of sudden death cases. Among sudden death victims, most risk factors and comorbidities were more common in the older age group, except for obesity which was more common in younger cases, and diabetes which was equally prevalent in younger and older cases. Compared to living population, sudden death cases had higher prevalence of atherosclerotic risk factors across all gender and age groups. Sudden death cases had a numerically higher number of risk factors compared to living population, regardless of age group or presence of CAD.

Conclusions

Coronary artery disease is not common among sudden death cases, but risk factors and comorbidities are prevalent. Our findings support the changing etiology of sudden death. In the absence of clinically diagnosed CAD, use of novel imaging modalities and biomarkers may identify high-risk individuals and lead to prevention of sudden death.
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Metadaten
Titel
Coronary Artery Disease and Atherosclerotic Risk Factors in a Population-Based Study of Sudden Death
verfasst von
Golsa Joodi, MD, MPH
Joan A. Maradey, MD
Brittany Bogle, PhD, MPH
Mojtaba Mirzaei, MD, MPH
Murrium I. Sadaf, MD
Irion Pursell, RN, BSN
Cory Henderson, MD
John Paul Mounsey, BM BCh, PhD
Ross J. Simpson Jr, MD, PhD
Publikationsdatum
05.12.2019
Verlag
Springer US
Erschienen in
Journal of General Internal Medicine / Ausgabe 2/2020
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-019-05486-6

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