CORR Insights^®: How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

Excerpt

Osteomyelitis treatment is based on surgical débridement and systemic administration of antibiotics for prolonged time. However, intravenous therapy may not ensure adequate local concentration of antibiotics in necrotic bone tissue to eradicate biofilm-related infections, and it may cause systemic complications and toxicity. In the current study, Lee and colleagues investigated the in vitro antimycobacterial activity and elution characteristics of bone cement loaded with streptomycin or amoxicillin and clavulanate for the treatment of musculoskeletal tuberculosis. In a previous study, the authors demonstrated the in vitro antimycobacterial effectiveness of isoniazid when incorporated in bone cement [5]. However, the lack of a powder form of isoniazid limits its practical application as an antibiotic that can be used in depot form in bone cement. …