The original version of this article, published on 31 July 2019, unfortunately contained a mistake.
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We regret to inform readers of an error in our original publication [1]. Contrary to what is claimed in the abstract, the analysis did not include a variable on the type of surgical procedure performed, as this variable was unintentionally left out of the analysis. In a rerun of the analysis, we excluded 28 persons in the eligible cohort (n=49,765) who were missing data on type of surgical procedure. Among the remaining 49,737 persons, 66.6% (n=33,118) were treated with internal fixation, 33.0% (n=16,418) with hemiarthroplasty or total hip arthroplasty, and 0.4% (n=201) with other or no treatment. The association between bisphosphonate use and mortality was unchanged after adjustment for type of surgical procedure and the other confounders (fully-adjusted hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.80-0.90).
Matching on type of surgical procedure and the other confounders resulted in a sub-cohort of 5,108 bisphosphonate users and 5,108 controls. Similar numbers of bisphosphonate users and controls were treated with internal fixation (3,444 [67.4%] and 3,462 [67.8%], standardized mean difference [SMD] 0.01), hemiarthroplasty or total hip arthroplasty (1,647 [32.2%] and 1,631 [31.9%]; SMD 0.01), and other or no treatment (17 [0.3%] and 15 [0.3%]; SMD 0.01). The association between bisphosphonate use and mortality (HR 0.84, 95% CI 0.79-0.91) was similar to that presented in the original publication. The Kaplan-Meier curves and risk ratio curves showed lower mortality in the bisphosphonate group from day 2 of follow-up, instead of from day 6, as in the original analysis (Fig. 1 and Fig. 2). In the updated analysis, the association was significant from the second month of follow-up, instead of from the second week of follow-up, as in the original analysis.
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This updated analysis confirms our original conclusion that the mortality rate is lower in bisphosphonate users soon after treatment initiation. However, this association was not statistically significant as early as was shown in the original analysis. We apologize for the error.
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