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Erschienen in: Digestive Diseases and Sciences 3/2019

13.11.2018 | Original Article

Correlation Between Anti-TNF Serum Levels and Endoscopic Inflammation in Inflammatory Bowel Disease Patients

verfasst von: María Chaparro, Manuel Barreiro-de Acosta, Ana Echarri, Rosendo Almendros, Jesús Barrio, Jordina Llao, Fernando Gomollón, Maribel Vera, José Luis Cabriada, Jordi Guardiola, Iván Guerra, Belén Beltrán, Oscar Roncero, David Busquets, Carlos Taxonera, Xavier Calvet, Rocío Ferreiro-Iglesias, Virginia Ollero Pena, David Bernardo, María G. Donday, Ana Garre, Ana Godino, Ana Díaz, Javier P. Gisbert

Erschienen in: Digestive Diseases and Sciences | Ausgabe 3/2019

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Abstract

Objectives

(a) To evaluate the diagnostic accuracy of anti-TNF trough levels to predict mucosal healing in inflammatory bowel disease (IBD); (b) to determine the best cut-off point to predict mucosal healing in IBD patients treated with anti-TNF.

Methods

This is a multicenter, prospective study. IBD patients under anti-TNF treatment for at least 6 months that had to undergo an endoscopy were included. Mucosal healing was defined as: Simple endoscopic score for Crohn’s Disease < 3 for Crohn’s disease (CD), Rutgeerts score < i2 for CD in postoperative setting, or Mayo endoscopic score ≤ 1 for ulcerative colitis (UC). Anti-TNF concentrations were measured using SMART ELISAs at trough.

Results

A total of 182 patients were included. Anti-TNF trough levels were significantly higher among patients that had mucosal healing than among those who did not. The area under the curve of infliximab for mucosal healing was 0.63 (best cutoff value 3.4 μg/mL), and for adalimumab 0.60 (best cutoff value 7.2 μg/mL). In the multivariate analysis, having anti-TNF drug levels above the cutoff values [odds ratio (OR) 3.1]) and having UC instead of CD (OR 4) were associated with a higher probability of having mucosal healing. Additionally, the need for an escalated dosage (OR 0.2) and current smoking habit (OR 0.2) were also associated with a lower probability of mucosal healing.

Conclusions

There was an association between anti-TNF trough levels and mucosal healing in IBD patients; however, the accuracy of the determination of infliximab and adalimumab concentrations able to predict mucosal healing was suboptimal.
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Metadaten
Titel
Correlation Between Anti-TNF Serum Levels and Endoscopic Inflammation in Inflammatory Bowel Disease Patients
verfasst von
María Chaparro
Manuel Barreiro-de Acosta
Ana Echarri
Rosendo Almendros
Jesús Barrio
Jordina Llao
Fernando Gomollón
Maribel Vera
José Luis Cabriada
Jordi Guardiola
Iván Guerra
Belén Beltrán
Oscar Roncero
David Busquets
Carlos Taxonera
Xavier Calvet
Rocío Ferreiro-Iglesias
Virginia Ollero Pena
David Bernardo
María G. Donday
Ana Garre
Ana Godino
Ana Díaz
Javier P. Gisbert
Publikationsdatum
13.11.2018
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 3/2019
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-018-5362-3

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