The online version of this article (doi:10.1186/1758-5996-6-115) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
Regarding the contribution of each author, WHS designed the study and in charge of the whole program. KWL analyzed and interpreted the data and wrote the manuscript. ICT and WJL performed the laboratory work. WLL, SYL, ITL, JSW and CPF recruited the patients, and critically reviewed the manuscript for important intellectual content. All authors read and approved the final manuscript.
It has been recognized that reduction of abdominal visceral fat and subcutaneous fat are associated with improvement in insulin-resistance (IR) after weight loss. However, few studies have investigated the correlation of reduction in epicardial adipose tissue (EAT) with improvement of IR index after weight loss in obese non-diabetic men with metabolic syndrome (MetS).
We prospectively enrolled 32 non-diabetic men with MetS for a 3-month weight reduction program mainly by diet control and exercise. Magnetic resonance imaging (MRI) examinations were used to measure EAT, subcutaneous fat, and abdominal visceral fat. Anthropometric parameters, oral glucose tolerance test (OGTT), and serum adipokines were assessed before and after the weight loss program. After a 3-month weight loss program, 27 obese MetS men had significant weight loss >5% (97 ± 14 to 87 ± 14 kg, with a 10.7 % decrease, p < 0.001). Multivariate analysis revealed that the decrement ratio of superior interventricular groove (SIVG) EAT thickness (r = 0.322, p = 0.044) and serum leptin (r = 0.626, p < 0.001) significantly correlated with the percentage improvements of fasting HOMA-IR index. Furthermore, the decrement ratio of SIVG EAT thickness (r = −0.370, p = 0.017) and decrement ratio of subcutaneous fat area (r = −0.673, p = 0.006) were significantly correlated with improvement of OGTT-derived Matsuda insulin-sensitivity index.
The decrement ratio of SIVG EAT correlated with improvement of both HOMA-IR and OGTT-derived Matsuda insulin-sensitivity indexes after weight loss in obese non-diabetic men with MetS.
(Multi-faceted Evaluations Following Weight Reduction in Subjects with Metabolic Syndrome NCT01065753 on Feb 8, 2010).
Authors’ original file for figure 113098_2014_376_MOESM1_ESM.tiff
Grundy SM, Hansen B, Smith SC, Cleeman JI, Kahn RA: Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation. 2004, 109 (4): 551-556. 10.1161/01.CIR.0000112379.88385.67. CrossRefPubMed
Malik S, Wong ND, Franklin SS, Kamath TV, L’Italien GJ, Pio JR, Williams GR: Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004, 110 (10): 1245-1250. 10.1161/01.CIR.0000140677.20606.0E. CrossRefPubMed
Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Sopko G, Reis SE: Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women’s Ischemia Syndrome Evaluation. Circulation. 2004, 109 (6): 714-721. 10.1161/01.CIR.0000115517.26897.A7. CrossRefPubMed
Marchington JM, Pond CM: Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro. Int J Obes. 1990, 14 (12): 1013-1022. PubMed
Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O’Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y: Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003, 108 (20): 2460-2466. 10.1161/01.CIR.0000099542.57313.C5. CrossRefPubMed
Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, Gallo P, di Gioia CR: Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine. 2005, 29 (6): 251-255. PubMed
Wang TD, Lee WJ, Shih FY, Huang CH, Chang YC, Chen WJ, Lee YT, Chen MF: Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat. J Clin Endocrinol Metab. 2009, 94 (2): 662-669. 10.1210/jc.2008-0834. CrossRefPubMed
Wang CP, Hsu HL, Hung WC, Yu TH, Chen YH, Chiu CA, Lu LF, Chung FM, Shin SJ, Lee YJ: Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis. Clin Endocrinol (Oxf). 2009, 70 (6): 876-882. 10.1111/j.1365-2265.2008.03411.x. CrossRef
Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F: Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003, 88 (11): 5163-5168. 10.1210/jc.2003-030698. CrossRefPubMed
Wang TD, Lee WJ, Shih FY, Huang CH, Chen WJ, Lee YT, Shih TT, Chen MF: Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity. Atherosclerosis. 2010, 213 (1): 279-287. 10.1016/j.atherosclerosis.2010.07.055. CrossRefPubMed
Payne GA, Borbouse L, Kumar S, Neeb Z, Alloosh M, Sturek M, Tune JD: Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol. 2010, 30 (9): 1711-1717. 10.1161/ATVBAHA.110.210070. PubMedCentralCrossRefPubMed
Cheng KH, Chu CS, Lee KT, Lin TH, Hsieh CC, Chiu CC, Voon WC, Sheu SH, Lai WT: Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond). 2008, 32 (2): 268-274. 10.1038/sj.ijo.0803726. CrossRef
de Vos AM, Prokop M, Roos CJ, Meijs MF, van der Schouw YT, Rutten A, Gorter PM, Cramer MJ, Doevendans PA, Rensing BJ, Bartelink ML, Velthuis BK, Mosterd A, Bots ML: Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. Eur Heart J. 2008, 29 (6): 777-783. 10.1093/eurheartj/ehm564. CrossRefPubMed
Liang KW, Tsai IC, Lee WJ, Lee IT, Lee WL, Lin SY, Wan CJ, Fu CP, Ting CT, Sheu WH: MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome. Obesity (Silver Spring). 2012, 20 (3): 525-532. 10.1038/oby.2011.155. CrossRef
Fu CP, Sheu WH, Lee IT, Tsai IC, Lee WJ, Liang KW, Lee WL, Lin SY: Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men. Clin Chim Acta. 2013, 421C: 98-103. CrossRef
Third Report of the National Cholesterol Education Program (NCEP): Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002, 106 (25): 3143-3421.
Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN, Lang HF, Wu CS, Wan CJ, Lee IT: Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring). 2008, 16 (5): 1033-1038. 10.1038/oby.2008.37. CrossRef
Sheu WH, Chin HM, Lee WJ, Wan CJ, Su HY, Lang HF: Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women. Life Sci. 2005, 76 (18): 2137-2145. 10.1016/j.lfs.2004.12.002. CrossRefPubMed
Soyama A, Nishikawa T, Ishizuka T, Ito H, Saito J, Yagi K, Saito Y: Clinical usefulness of the thickness of preperitoneal and subcutaneous fat layer in the abdomen estimated by ultrasonography for diagnosing abdominal obesity in each type of impaired glucose tolerance in man. Endocr J. 2005, 52 (2): 229-236. 10.1507/endocrj.52.229. CrossRefPubMed
Liang KW, Sheu WH, Lee WL, Liu TJ, Ting CT, Hsieh YC, Wang KY, Chen YT, Lee WJ: Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. Int J Cardiol. 2008, 129 (1): 76-80. 10.1016/j.ijcard.2007.05.027. CrossRefPubMed
Bashir A, Laciny E, Lassa-Claxton S, Yarasheski KE: Magnetic resonance imaging for quantifying regional adipose tissue in human immunodeficiency virus-infected persons with the cardiometabolic syndrome. J Cardiometab Syndr. 2008, 3 (2): 115-118. 10.1111/j.1559-4572.2008.07595.x. PubMedCentralCrossRefPubMed
Fluchter S, Haghi D, Dinter D, Heberlein W, Kuhl HP, Neff W, Sueselbeck T, Borggrefe M, Papavassiliu T: Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging. Obesity (Silver Spring). 2007, 15 (4): 870-878. 10.1038/oby.2007.591. CrossRef
Reinehr T, Kratzsch J, Kiess W, Andler W: Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children. Int J Obes (Lond). 2005, 29 (10): 1230-1235. 10.1038/sj.ijo.0803027. CrossRef
Reinehr T, Roth CL: A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes (Lond). 2010, 34 (5): 852-858. 10.1038/ijo.2009.282. CrossRef
Bluher M, Rudich A, Kloting N, Golan R, Henkin Y, Rubin E, Schwarzfuchs D, Gepner Y, Stampfer MJ, Fiedler M, Thiery J, Stumvoll M, Shai I: Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care. 2012, 35 (2): 342-349. 10.2337/dc11-1267. PubMedCentralCrossRefPubMed
Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M: Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance. J Clin Endocrinol Metab. 2006, 91 (11): 4620-4627. 10.1210/jc.2006-1044. CrossRefPubMed
- Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men
Wayne H-H Sheu
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