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Journal of Cancer Research and Clinical Oncology

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01.01.2014 | Original Paper

Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China

verfasst von: Chuan-Bao Zhang, Zhao-Shi Bao, Hong-Jun Wang, Wei Yan, Yan-Wei Liu, Ming-Yang Li, Wei Zhang, Ling Chen, Tao Jiang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2014

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Abstract

Purpose

Isocitrate dehydrogenase (IDH) gene mutation is one of the most exciting new advances in these years. It has been reported that IDH gene frequently altered in grade II and grade III gliomas. We aimed to identify the mutation frequency of IDH genes in Chinese anaplastic glioma patients, the association of IDH gene mutation with other clinical and molecular pathological features and the prognostic value of it.

Methods

We performed polymerase chain reaction-based IDH gene mutation detection in 203 anaplastic glioma patients from China.

Results

A total of 108 and 3 patients harbored IDH1 and IDH2 gene mutation, respectively. And there was a higher proportion of MGMT promoter methylation, frontal lobe location, and better outcome and lower proportion of temporal location in IDH-mutated samples. There were hardly any significant association between protein expression level of well-known markers and IDH mutation. Anaplastic oligoastrocytoma and anaplastic astrocytoma patients with IDH gene mutation showed similar prognosis with anaplastic oligodendroglioma patients with wild-type IDH gene.

Conclusions

IDH gene mutation is a good prognostic marker and a potential substratification factor for anaplastic glioma patients.

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Titel: Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China
verfasst von: Chuan-Bao Zhang
Zhao-Shi Bao
Hong-Jun Wang
Wei Yan
Yan-Wei Liu
Ming-Yang Li
Wei Zhang
Ling Chen
Tao Jiang
Publikationsdatum: 01.01.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2014
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-013-1519-9

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Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China

Abstract

Purpose

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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