Correlation of preoperative 18F-FDG-PET/CT tumor staging and maximum standardized uptake values with preoperative CT, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma
- 01.04.2025
- Research
Erschienen in:
- Verfasst von
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Gunnar Müller
Gunnar Müller
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Gunnar Müller and Daniel A. Veit contributed equally to this work.
- Department of Pathology, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Department of Pathology, University Hospital Aachen, 52074, Aachen, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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Daniel A. Veit
Daniel A. Veit
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Gunnar Müller and Daniel A. Veit contributed equally to this work.
- Department of Nuclear Medicine, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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Philipp Becker
Philipp Becker
- Department of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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Daniel G. E. Thiem
Daniel G. E. Thiem
- Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131, Mainz, Germany
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Peer W. Kämmerer
Peer W. Kämmerer
- Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131, Mainz, Germany
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Birte Diekmeyer
Birte Diekmeyer
- Department of Nuclear Medicine, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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Richard Werkmeister
Richard Werkmeister
- Department of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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Diana Heimes
Diana Heimes
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Gunnar Müller and Daniel A. Veit contributed equally to this work.
- Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131, Mainz, Germany
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Andreas Pabst
Korrespondierender Autor Andreas Pabst
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Gunnar Müller and Daniel A. Veit contributed equally to this work.
- Department of Oral and Maxillofacial Surgery, German Armed Forces Central Hospital, 56072, Koblenz, Germany
- Head and Neck Cancer Center Koblenz (KHTK), Koblenz, Germany
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- Erschienen in
- Clinical Oral Investigations | Ausgabe 4/2025
Abstract
Introduction
This study aimed to correlate preoperative 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) tumor staging, and maximum standardized uptake values (SUVmax) with preoperative CT data, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma (OSCC).
Material and methods
Thirty-seven OSCC patients staged via full-body 18F-FDG-PET/CT, including contrast agent CT of the head and neck in 2020 and 2021, were enclosed. Patients received tumor resection and stage-dependent neck dissection. Preoperative clinical (c) 18F-FDG-PET/CT UICC tumor stages and TNM classifications were correlated to corresponding CT and to postoperative histopathological (p) UICC tumor stages and TNM classifications. SUVmax of the primary tumor was associated with pUICC and pTNM, including extranodal extension (ENE), perineural invasion (Pn), lymphatic spread (L), vascular invasion (V), tumor grading (G), and -thickness.
Results
Comparing 18F-FDG-PET/CT and CT, cUICC, cT, and cN differed in 32.3%, 16.7%, and 37.8% of the cases, respectively. For 18F-FDG-PET/CT, a moderate correlation was found between c- and pUICC (0.494; p = 0.0018) with a misestimation of c- compared to pUICC in 43.2% of the cases. Comparing c- and pTNM, misestimations concerning c- and pT were seen in 51.4% and concerning c- and pN in 37.8% of the cases. An increased SUVmax significantly correlated with increased pT- and pUICC (adjusted Odds ratio 1.103; p = 0.042 and 1.126; p = 0.021, respectively). The predictive quality of an SUVmax cutoff value for detecting cervical lymph node metastases and G was poor, as indicated by the low AUC values from the ROC analysis. No correlations were found between SUVmax and ENE, Pn-, L-, and V-status. A strong correlation was found between SUVmax and tumor thickness with an adjusted coefficient of 1.034 (p = 0.01).
Conclusion
The predictive value of 18F-FDG-PET/CT and SUVmax on histopathological tumor classification and parameters appears limited.
Clinical relevance
18F-FDG-PET/CT can not unreservedly be recommended for primary OSCC staging. There is an urgent need to specify its indications in detail further.
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- Titel
- Correlation of preoperative 18F-FDG-PET/CT tumor staging and maximum standardized uptake values with preoperative CT, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma
- Verfasst von
-
Gunnar Müller
Daniel A. Veit
Philipp Becker
Daniel G. E. Thiem
Peer W. Kämmerer
Birte Diekmeyer
Richard Werkmeister
Diana Heimes
Andreas Pabst
- Publikationsdatum
- 01.04.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Clinical Oral Investigations / Ausgabe 4/2025
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771 - DOI
- https://doi.org/10.1007/s00784-025-06252-1
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