Fracture healing process and different from that of other tissues and organs, not only for a long time, involved in many cells and in different healing stages have different cells and cytokines, the healing mechanism is more complicated. Androgen plays an important role in normal bone growth and regulation. Clinical studies have shown that androgen can stimulate the proliferation and differentiation of osteoblasts, increase the cytoplasm of the cells, and increase RNA and protein synthesis, and androgen can promote the secretion of growth hormone. Elderly fracture patients are often prone to Euthyroid Sick Syndrome (ESS); ESS showed that patients had abnormal thyroid hormone levels, but no thyroid disease performance. Elderly fracture patients with ESS present with low thyroid hormone levels and are associated with the severity of the disease. It is also reported that thyroid hormone monitoring is of great significance for the rehabilitation of patients undergoing orthopedic surgery [
13,
14]. Parathyroid hormone secreted by the parathyroid gland consists of 84 amino acid residues. Its physiological function is to regulate calcium and phosphorus metabolism in the body. Therefore, high PTH regulates the production of adiponectin in the adipose tissue [
15]. Intermittent low-dose recombinant human PTH promotes bone healing by upregulating the expression of mRNA and protein levels of the osteogenic gene Runx2 in the early stages of fracture healing [
16]. Parathyroid hormone has been used to treat osteoporosis and reduce the risk of fracture. Animal studies on different fracture models have shown that the addition of PTH promotes fracture healing, increases the volume of the epiphysis and the mineral salt content of the fracture zone, and increases traction resistance [
17,
18]. In human studies, PTH has a positive effect on fracture healing, and it seems to affect the role of bone growth factor. A prospective study of 32 patients with nonunion fracture healing from Kastirr et al. found that 95% nonunion patients treated with PTH eventually healed after treatment [
19]. We found that PTH levels in healing effective group were higher than those in delayed healing group at the 7 and 14 days after fracture, indicating the role of PTH in fracture healing. PTH is the first bone anabolic drug approved for the treatment of osteoporosis, preventing the delay of fracture healing due to aging [
20,
21]. In some high-risk groups, such as the elderly, malnutrition, and postmenopausal women, PTH has better prospects for fracture treatment.