Background
Methods
Subjects
Collection of clinical data and laboratory measurements
Genotyping
Statistical analysis
Results
Characteristics | Carotid plaque (n = 408) | Controls (n = 493) | P value |
---|---|---|---|
Age (years) | 68.29 ± 9.80 | 64.89 ± 9.16 | <0.001 |
Female (%) | 44.36 | 57.4 | <0.001 |
BMI (Kg/m2) | 23.66 ± 3.98 | 23.60 ± 3.21 | NS |
Systolic blood pressure (mmHg) | 136.35 ± 16.18 | 127.75 ± 16.48 | <0.001 |
Diastolic blood pressure (mmHg) | 81.49 ± 10.21 | 76.02 ± 9.47 | <0.001 |
Fasting plasma glucose (mmol/L) | 5.53 ± 1.81 | 5.60 ± 1.68 | NS |
Smoking (%) | 33.58 | 30.43 | NS |
TC (mmol/L) | 4.75 ± 1.05 | 4.85 ± 1.11 | NS |
TG (mmol/L) | 1.54 ± 1.11 | 1.50 ± 1.11 | NS |
LDL-C (mmol/L) | 2.58 ± 0.74 | 2.59 ± 0.75 | NS |
HDL-C (mmol/L) | 1.14 ± 0.31 | 1.22 ± 0.33 | <0.001 |
Carotid plaque | Controls | ||||
---|---|---|---|---|---|
Analyzing Model: SNPs | n1 | Frequency (%) | n1 | Frequency (%) | P value § |
rs3747823 | |||||
Additive: GG/AG/AA | 263/126/18 | 64.6/31.0/4.4 | 298/155/27 | 62.1/32.3/5.6 | NS |
Dominant: (AA + AG)/GG | 144/263 | 35.4/64.6 | 182/298 | 38.0/62.0 | NS |
Recessive: AA/(AG + GG) | 18/389 | 4.4/95.6 | 27/453 | 5.6/94.4 | NS |
rs7020782 | |||||
Additive: AA/AC/CC | 166/190/51 | 40.8/46.7/12.5 | 302/159/29 | 61.6/32.4/6.0 | <0.001 |
Dominant: (AC + CC)/AA | 241/166 | 59.2/40.8 | 188/302 | 38.4/61.6 | <0.001 |
recessive: CC/(AC + AA) | 51/356 | 12.5/87.5 | 29/461 | 5.9/94.1 | 0.001 |
rs13290387 | |||||
Additive: GG/CG/CC | 207/163/31 | 51.6/40.6/7.7 | 269/179/35 | 55.7/37.1/7.2 | NS |
Dominant: (CG + CC)/GG | 194/207 | 48.4/51.6 | 214/269 | 44.3/55.7 | NS |
Recessive: CC/(CG + GG) | 31/370 | 7.7/92.3 | 35/448 | 7.2/92.8 | NS |
SNPs analyzing Model‡ | Crude OR (95 % CI) 1 | P value1 | Adjusted OR (95 % CI)§ | P value§ |
---|---|---|---|---|
rs7020782 | ||||
Dominant | 2.33 (1.79-3.05) | <0.001 | 2.60 (1.93-3.48) | <0.001 |
Recessive | 2.28 (1.41-3.66) | 0.001 | 2.36 (1.42-3.92) | 0.001 |
Additive | 3.20 (1.95-5.24)† | <0.001 | 3.48 (2.05-5.92)† | <0.001 |