Background
Methods
Tc-99 m-ECD SPECT
Neuropsychological tests
Results
Tc-99 m-ECD SPECT
Patient # | Age/Gender | Education level (years) | Serum cobalamin level (pg/ml) | Clinical Dementia Rating | Mini-Mental State Examination | Cognitive Abilities Screening Instrument | Single-photon emission computed tomography | Clinical presentations |
---|---|---|---|---|---|---|---|---|
1 | 73/F | 0 | 199 | 1 | 12 | 34 | Bil. F. T. P. Tha. (more severe in Lt) Lt BG. | Forgetfulness, attention deficits, dysexcutive syndrome, and dementia |
2 | 80/F | 0 | 230 | 1 | 13 | 42 | Bil. F. T. Tha. Rt BG | Forgetfulness and dementia |
3 | 60/F | 6 | 207 | 0.5 | 24 | 78 | Bil. F. T. Tha. | Insomnia, forgetfulness, attention deficits, and dysexcutive syndrome |
4 | 81/M | 12 | 177 | 0.5 | 25 | 82 | Bil. F. T. Tha.BG (more severe in Rt) | Depression, forgetfulness, attention deficits, and dysexcutive syndrome |
5 | 53/F | 6 | 218 | 0.5 | 22 | 65 | Bil. F. T. Tha. | Dysexecutive syndrome, anxiety, and insomnia |
6 | 74/F | 6 | 209 | 0.5 | 21 | 61 | Bil. F. T. Tha. | Forgetfulness, attention deficits, dysexcutive syndrome, and anxiety |
7 | 58/F | 12 | 210 | 0 | 28 | 88 | Bil. F. T. Tha. | Anxiety, insomnia, and dysexcutive syndrome |
8 | 56/F | 12 | 229 | 0.5 | 27 | 87 | Bil. T. Tha. | Dysexecutive syndrome |
9 | 65/F | 6 | 202 | 0.5 | 26 | 93 | Bil. T. Rt Tha. | Attention deficits |
10 | 61/M | 6 | 108 | 0.5 | 27 | 75 | Bil. T. (more severe in Lt) Lt BG | Irritability, forgetfulness, and dysexcutive syndrome |
11 | 29/F | 12 | 199 | 0 | N.A. | N.A. | Lt T. Tha. | Irritability, anxiety, dysthymia, and sleep disorders |
12 | 41/M | 12 | 175 | 0 | N.A. | N.A | Bil. T. Rt BG | Anxiety |
Frontal regions | Temporal regions | Parietal regions | Thalamus | Basal ganglia | ||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rt | Lt | Rt | Lt | Rt | Lt | Rt | Lt | Rt | Lt | |||||||||||||||||||||
Patient # | ||||||||||||||||||||||||||||||
1 | .81 | .77 | .78 | .82 | .80 | .76 | .80 | .78 | .79 | .75 | .75 | .71 | .79 | .78 | .79 | .79 | .79 | .80 | .76 | .75 | .79 | .72 | .73 | .68 | .82 | .82 | .81 | .74 | .74 | .74 |
.79
|
.79
|
.79
|
.74
|
.79
|
.79
|
.77
|
.71
|
.82
|
.74
| |||||||||||||||||||||
2 | .78 | .80 | .80 | .74 | .74 | .75 | .79 | .81 | .78 | .73 | .74 | .76 | .95 | .92 | .95 | .82 | .82 | .80 | .72 | .72 | .71 | .70 | .71 | .72 | .72 | .70 | .71 | .80 | .81 | .81 |
.79
|
.74
|
.79
|
.74
|
.94
|
.81
|
.72
|
.71
|
.71
|
.81
| |||||||||||||||||||||
3 | .76 | .80 | .81 | .80 | .80 | .76 | .75 | .75 | .76 | .76 | .78 | .81 | .99 | 1.01 | .99 | .95 | .95 | .99 | .73 | .72 | .73 | .68 | .68 | .68 | .96 | .95 | .96 | .92 | .93 | .93 |
.79
|
.79
|
.75
|
.78
|
1.00
|
.96
|
.73
|
.68
|
.96
|
.93
| |||||||||||||||||||||
4 | .68 | .67 | .72 | .78 | .77 | .77 | .76 | .75 | .76 | .77 | .78 | .78 | .89 | .87 | .85 | .92 | .95 | .94 | .73 | .76 | .76 | .78 | .78 | .78 | .61 | .63 | .67 | .78 | .77 | .74 |
.72
|
.77
|
.76
|
.78
|
.87
|
.94
|
.75
|
.78
|
.64
|
.76
| |||||||||||||||||||||
5 | .76 | .76 | .80 | .73 | .80 | .77 | .75 | .75 | .71 | .77 | .76 | .76 | .82 | .82 | .86 | .83 | .82 | .83 | .77 | .78 | .78 | .67 | .66 | .72 | .83 | .84 | .83 | .82 | .82 | .82 |
.77
|
.77
|
.74
|
.76
|
.83
|
.83
|
.78
|
.68
|
.83
|
.82
| |||||||||||||||||||||
6 | .75 | .77 | .80 | .80 | .75 | .83 | .78 | .78 | .80 | .77 | .76 | .77 | .95 | .93 | .94 | .94 | .95 | .96 | .78 | .78 | .80 | .78 | .79 | .79 | .89 | .87 | .87 | .86 | .85 | .88 |
.77
|
.79
|
.79
|
.77
|
.94
|
.95
|
.79
|
.79
|
.88
|
.86
| |||||||||||||||||||||
7 | .78 | .80 | .76 | .79 | .77 | .77 | .75 | .75 | .74 | .75 | .75 | .73 | .85 | .87 | .85 | .84 | .81 | .83 | .67 | .69 | .69 | .69 | .69 | .70 | .91 | .92 | .94 | .93 | .95 | .93 |
.78
|
.78
|
.75
|
.74
|
.86
|
.83
|
.68
|
.69
|
.92
|
.94
| |||||||||||||||||||||
8 | .84 | .88 | .87 | .90 | .92 | .88 | .75 | .70 | .70 | .79 | .79 | .79 | .90 | .89 | .89 | .92 | .92 | .93 | .71 | .69 | .72 | .79 | .82 | .75 | .91 | .90 | .87 | .96 | .95 | .96 |
.86
|
.90
|
.72
|
.79
|
.89
|
.92
|
.71
|
.79
|
.89
|
.96
| |||||||||||||||||||||
9 | .86 | .87 | .85 | .97 | .92 | .94 | .77 | .77 | .77 | .80 | .79 | .79 | .82 | .83 | .82 | .97 | .94 | .97 | .66 | .65 | .64 | .83 | .83 | .83 | .94 | .92 | .92 | .96 | .99 | .95 |
.86
|
.94
|
.77
|
.79
|
.82
|
.96
|
.65
|
.83
|
.93
|
.97
| |||||||||||||||||||||
10 | .90 | .89 | .88 | .83 | .83 | .83 | .79 | .75 | .76 | .68 | .74 | .78 | .98 | .95 | .98 | .79 | .86 | .89 | .80 | .80 | .80 | .81 | .81 | .79 | .85 | .81 | .88 | .80 | .79 | .79 |
.89
|
.83
|
.77
|
.73
|
.97
|
.85
|
.80
|
.80
|
.85
|
.79
| |||||||||||||||||||||
11 | .93 | .92 | .86 | .83 | .88 | .90 | .82 | .82 | .81 | .72 | .72 | .72 | .98 | 1.02 | 1.00 | .95 | .85 | .91 | .86 | .84 | .80 | .77 | .72 | .74 | .98 | .99 | 1.00 | .95 | .93 | .95 |
.90
|
.87
|
.82
|
.72
|
1.00
|
.90
|
.83
|
.74
|
.99
|
.94
| |||||||||||||||||||||
12 | .86 | .92 | .94 | .91 | .90 | .87 | .78 | .74 | .76 | .77 | .71 | .74 | .98 | .98 | .98 | .97 | .97 | .98 | .81 | .81 | .81 | .79 | .80 | .80 | .75 | .75 | .75 | .87 | .84 | .87 |
.91
|
.89
|
.76
|
.74
|
.98
|
.97
|
.81
|
.80
|
.75
|
.86
|
Neuropsychological tests
Tc-99 m-ECD SPECT follow-up studies
Frontal regions | Temporal regions | Parietal regions | Thalamus | Basal ganglia | ||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rt | Lt | Rt | Lt | Rt | Lt | Rt | Lt | Rt | Lt | |||||||||||||||||||||
Patient# | ||||||||||||||||||||||||||||||
1 before | .81 | .77 | .78 | .82 | .80 | .76 | .80 | .78 | .79 | .75 | .75 | .71 | .79 | .78 | .79 | .79 | .79 | .80 | .76 | .75 | .79 | .72 | .73 | .68 | .82 | .82 | .81 | .74 | .74 | .74 |
.79
|
.79
|
.79
|
.74
|
.79
|
.79
|
.77
|
.71
|
.82
|
.74
| |||||||||||||||||||||
1 after | .79 | .81 | .81 | .76 | .76 | .80 | .89 | .87 | .88 | .77 | .77 | .75 | 1.04 | 1.05 | 1.05 | .95 | .93 | .91 | .79 | .78 | .78 | .72 | .72 | .72 | .85 | .84 | .85 | .74 | .74 | .74 |
.80
|
.77
|
.88
|
.76
|
1.05
|
.93
|
.78
|
.72
|
.85
|
.74
| |||||||||||||||||||||
3 before | .76 | .80 | .81 | .80 | .80 | .76 | .75 | .75 | .76 | .76 | .78 | .81 | .99 | 1.01 | .99 | .95 | .95 | .99 | .73 | .72 | .73 | .68 | .68 | .68 | .96 | .95 | .96 | .92 | .93 | .93 |
.79
|
.79
|
.75
|
.78
|
1.00
|
.96
|
.73
|
.68
|
.96
|
.93
| |||||||||||||||||||||
3 after | .92 | .92 | .90 | .87 | .87 | .87 | .92 | .92 | .93 | .90 | .86 | .86 | 1.00 | 1.01 | 1.01 | .96 | .97 | .98 | .73 | .73 | .72 | .74 | .75 | .75 | .94 | .94 | .94 | .93 | .93 | .92 |
.91
|
.87
|
.92
|
.87
|
1.01
|
.97
|
.73
|
.75
|
.94
|
.93
| |||||||||||||||||||||
7 before | .78 | .80 | .76 | .79 | .77 | .77 | .75 | .75 | .74 | .75 | .75 | .73 | .85 | .87 | .85 | .84 | .81 | .83 | .67 | .69 | .69 | .69 | .69 | .70 | .91 | .92 | .94 | .93 | .95 | .93 |
.78
|
.78
|
.75
|
.74
|
.86
|
.83
|
.68
|
.69
|
.92
|
.94
| |||||||||||||||||||||
7 after | .88 | .88 | .82 | .88 | .86 | .87 | .81 | .81 | .81 | .87 | .84 | .84 | .85 | .87 | .88 | .86 | .87 | .86 | .80 | .81 | .80 | .83 | .82 | .82 | .84 | .85 | .86 | .88 | .88 | .87 |
.86
|
.86
|
.81
|
.85
|
.87
|
.86
|
.80
|
.82
|
.85
|
.88
| |||||||||||||||||||||
8 before | .84 | .88 | .87 | .90 | .92 | .88 | .75 | .70 | .70 | .79 | .79 | .79 | .90 | .89 | .89 | .92 | .92 | .93 | .71 | .69 | .72 | .79 | .82 | .75 | .91 | .90 | .87 | .96 | .95 | .96 |
.86
|
.90
|
.72
|
.79
|
.89
|
.92
|
.71
|
.79
|
.89
|
.96
| |||||||||||||||||||||
8 after | .93 | .92 | .94 | .96 | .96 | .96 | 1.00 | 1.00 | 1.00 | 1.03 | 1.04 | 1.03 | .95 | .94 | .95 | 1.02 | 1.01 | .98 | .86 | .87 | .86 | .87 | .87 | .88 | .90 | .91 | .91 | .97 | .97 | .97 |
.92
|
.96
|
1.00
|
1.03
|
.95
|
1.00
|
.86
|
.87
|
.91
|
.97
|