nach oben

17.09.2018 | Brief Article

Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma

verfasst von: Ilwoo Park, Janine M. Lupo, Sarah J. Nelson

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-¹³C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM).

Procedures

C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-¹³C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of ΔR2* curve from the DSC images in the voxels containing tumor using a Pearson’s linear correlation.

Results

Normalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data.

Conclusions

Since the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.

Barrett T, Brechbiel M, Bernardo M, Choyke PL (2007) MRI of tumor angiogenesis. J Magn Reson Imaging 26:235–249CrossRefPubMed

Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson SJ (2011) Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro-Oncology 13:119–131CrossRefPubMed

Kim YE, Choi SH, Lee ST, Kim TM, Park CK, Park SH, Kim IH (2017) Differentiation between glioblastoma and primary central nervous system lymphoma using dynamic susceptibility contrast-enhanced perfusion MR imaging: comparison study of the manual versus semiautomatic segmentation method. Investig Magn Reson Imaging 21:9–19CrossRef

Kanda T, Fukusato T, Matsuda M, Toyoda K, Oba H, Kotoku J’, Haruyama T, Kitajima K, Furui S (2015) Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy. Radiology 276:228–232CrossRefPubMed

Marckmann P, Skov L, Rossen K, Dupont A, Damholt MB, Heaf JG, Thomsen HS (2006) Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. J Am Soc Nephrol 17:2359–2362CrossRefPubMed

Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 100:10158–10163CrossRefPubMedPubMedCentral

Day SE, Kettunen MI, Cherukuri MK, Mitchell JB, Lizak MJ, Morris HD, Matsumoto S, Koretsky AP, Brindle KM (2011) Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- ¹³C]pyruvate and 13C magnetic resonance spectroscopic imaging. Magn Reson Med 65:557–563CrossRefPubMed

Park I, Larson PE, Zierhut ML et al (2010) Hyperpolarized ¹³C magnetic resonance metabolic imaging: application to brain tumors. Neuro-Oncology 12:133–144CrossRefPubMedPubMedCentral

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO (2014) Changes in pyruvate metabolism etected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res 74:7115–7124CrossRefPubMedPubMedCentral

10.

Ravera E, Shimon D, Feintuch A, Goldfarb D, Vega S, Flori A, Luchinat C, Menichetti L, Parigi G (2015) The effect of Gd on trityl-based dynamic nuclear polarisation in solids. Phys Chem Chem Phys 17:26969–26978CrossRefPubMed

11.

Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB (2007) Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized ¹³C. J Magn Reson 187:357–362CrossRefPubMed

12.

Boxerman JL, Schmainda KM, Weisskoff RM (2006) Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade whereas uncorrected maps do not AJNR, Am J Neuroradiol 27:859–867

13.

Hu LS, Baxter LC, Pinnaduwage DS, Paine TL, Karis JP, Feuerstein BG, Schmainda KM, Dueck AC, Debbins J, Smith KA, Nakaji P, Eschbacher JM, Coons SW, Heiserman JE (2010) Optimized preload leakage-correction methods to improve the diagnostic accuracy of dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in posttreatment gliomas. AJNR Am J Neuroradiol 31:40–48CrossRefPubMed

14.

Paulson ES, Schmainda KM (2008) Comparison of dynamic susceptibility-weighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumors. Radiology 249:601–613CrossRefPubMedPubMedCentral

15.

Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ (2013) Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D ¹³C magnetic resonance spectroscopic imaging. Magn Reson Med 70:33–39CrossRefPubMed

16.

Cunningham CH, Vigneron DB, Chen AP, Xu D, Nelson SJ, Hurd RE, Kelley DA, Pauly JM (2005) Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med 54:1286–1289CrossRefPubMed

17.

Lupo JM, Cha S, Chang SM, Nelson SJ (2005) Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol 26:1446–1454PubMed

18.

Cha S, Lu S, Johnson G, Knopp EA (2000) Dynamic susceptibility contrast MR imaging: correlation of signal intensity changes with cerebral blood volume measurements. J Magn Reson Imaging 11:114–119CrossRefPubMed

19.

Li J, Zhu S, Tong J, Hao H, Yang J, Liu Z, Wang Y (2016) Suppression of lactate dehydrogenase a compromises tumor progression by downregulation of the Warburg effect in glioblastoma. Neuroreport 27:110–115CrossRefPubMedPubMedCentral

20.

Valvona CJ, Fillmore HL, Nunn PB, Pilkington GJ (2016) The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor. Brain Pathol 26:3–17CrossRefPubMed

21.

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PEZ, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A (2011) ¹³C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab 14:131–142CrossRefPubMed

22.

Scroggins B, Matsuo M, White A et al (2018) Hyperpolarized [1-¹³C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect. Clin Cancer Res 24(13):3137–3148CrossRefPubMed

23.

Gordon JW, Vigneron DB, Larson PE (2017) Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized ¹³C imaging. Magn Reson Med 77:826–832CrossRefPubMed

24.

Larson PE, Bok R, Kerr AB et al (2010) Investigation of tumor hyperpolarized [1-¹³C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med 63:582–591CrossRefPubMedPubMedCentral

25.

Cunningham CH, Lau JY, Chen AP et al (2016) Hyperpolarized ¹³C metabolic MRI of the human heart: initial experience. Circ Res 119:1177–1182CrossRefPubMedPubMedCentral

26.

Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PEZ, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA (2013) Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. In: Sci Transl med 14;5(198):198ra108, vol 5, p 198ra108

27.

Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ (2018) Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med 80:864–873CrossRefPubMedPubMedCentral

28.

Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ (2017) Investigating tumor perfusion by hyperpolarized ¹³C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts. Magn Reson Med 77:841–847CrossRefPubMed

29.

von Morze C, Larson PE, Hu S et al (2011) Imaging of blood flow using hyperpolarized [¹³C]urea in preclinical cancer models. J Magn Reson Imaging 33:692–697CrossRef

30.

Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB (2017) Assessing prostate Cancer aggressiveness with hyperpolarized dual-agent 3D dynamic imaging of metabolism and perfusion. Cancer Res 77:3207–3216CrossRefPubMedPubMedCentral

31.

Walker CM, Michel KA, Zielinski RJ, Priebe W, Schellingerhout D, Bankson JA (2017) Combined hyperpolarized pyruvate and lactate as a proxy for hyperpolarized urea to measure tissue perfusion [abstract]. Proc Intl Soc Mag Reson Med 3708P

32.

Lau AZ, Miller JJ, Robson MD, Tyler DJ (2017) Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1-¹³C]pyruvate and ¹³C-urea. Magn Reson Med 77:151–158CrossRefPubMed

33.

Miloushev VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, DeAngelis LM, Mellinghoff IK, Brennan CW, Tabar V, Yang TJ, Holodny AI, Sosa RE, Guo YWW, Chen AP, Tropp J, Robb F, Keshari KR (2018) Metabolic imaging of the human brain with hyperpolarized ¹³C pyruvate demonstrates ¹³C lactate production in brain tumor patients. Cancer Res 78(14):3755–3760CrossRefPubMedPubMedCentral

Titel: Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma
verfasst von: Ilwoo Park
Janine M. Lupo
Sarah J. Nelson
Publikationsdatum: 17.09.2018
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 4/2019
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-018-1275-y

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma

Abstract

Purpose

Procedures

Results

Conclusions

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Procedures

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie