nach oben

Erschienen in:

01.06.2008 | Case Report

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

verfasst von: Donato Rigante, Rosanna Inzitari, Maurizio Carone, Chiara Fanali, Achille Stabile, Tiziana Cabras, Ettore Capoluongo, Stefania Gaspari, Giuseppe Barone, Massimo Castagnola

Erschienen in: Rheumatology International | Ausgabe 8/2008

Einloggen, um Zugang zu erhalten

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient’s salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

Bartunkova J, Sediva A, Vencovsy J, Tesar V (1999) Primary Sjögren syndrome in children and adolescents: proposal for diagnostic criteria. Clin Exp Rheumatol 17:381–386PubMed

Anaya JM, Ogawa N, Talal N (1995) Sjögren’s syndrome in childhood. J Rheumatol 22:1152–1158PubMed

Houghton K, Malleson P, Cabral D, Petty R, Tucker L (2005) Primary Sjogren’s syndrome in children and adolescents: are proposed diagnostic criteria applicable? J Rheumatol 32:2225–2232PubMed

Al-Hashimi I, Haghighat N, Fox PC (1998) Salivary electrophoresis in the diagnosis of Sjogren’s syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:542–547PubMedCrossRef

Ryu OH, Atkinson JC, Hoehn GT, Illei GG, Hart TC (2006) Identification of parotid salivary biomarkers in Sjogren’s syndrome by surface enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. Rheumatology 45:1077–1086PubMedCrossRef

Amado FM, Vitorino RM, Dominiques PM, Lobo MJ, Duarte JA (2005) Analysis of the human saliva proteome. Expert Rev Proteomics 2:521–539PubMedCrossRef

Inzitari R, Cabras T, Onnis G, Olmi C, Mastinu A, Sanna MT, Pellegrini MG, Castagnola M, Messana I (2005) Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins. Proteomics 5:805–815PubMedCrossRef

Nagler RM, Klein I, Zarzhevsky N, Drigues N, Reznick AZ (2002) Characterization of the differentiated antioxidant profile of human saliva. Free Radic Biol Med 32:268–277PubMedCrossRef

Lamkin MS, Oppenheim FG (1993) Structural features of salivary function. Crit Rev Oral Biol Med 4:251–259PubMed

10.

Veerman EC, van der Keybus PA, Vissink A, Nieuw Amerongen AV (1996) Human glandular salivas: their separate collection and analysis. Eur J Oral Sci 104:346–352PubMedCrossRef

11.

Edgar WM (1992) Saliva: its secretion, composition and functions. Br Dent J 172:305–312PubMed

12.

Amerongen NAV, Veerman ECI (2002) Saliva: the defender of oral cavity. Oral Dis 8:12–22PubMedCrossRef

13.

Borchers AT, Naguwa SM, Keen CL, Gershwin ME (2003) Immunopathogenesis of Sjögren’s syndrome. Clin Rev Allergy Immunol 25:89–104PubMedCrossRef

14.

Cimaz R, Casadei A, Rose C, Bartunkova J, Sediva A, Falcini F, Picco P, Taglietti M, Zulian F, Ten Cate R, Sztajnbok FR, Voulgari PV, Drosos AA (2003) Primary Sjögren syndrome in the paediatric age: a multicentre survey. Eur J Pediatr 162:661–665PubMedCrossRef

15.

Drosos AA, Tsiakou EK, Tsifetaki N, Politi EN, Siamopoulou-Mavridou A (1997) Subgroups of primary Sjögren’s syndrome in male and paediatric Greek patients. Ann Rheum Dis 56:333–335PubMedCrossRef

16.

Peluso G, De Santis M, Inzitari R, Fanali C, Cabras T, Messana I, Castagnola M, Ferraccioli GF (2007) Proteomic study of salivary peptides and proteins in patients with Sjögren’s syndrome before and after pilocarpine treatment. Arthritis Rheum 56:2216–2222PubMedCrossRef

17.

Inzitari R, Vento G, Capoluongo E, Boccacci S, Fanali C, Cabras T, Romagnoli C, Giardina B, Messana I, Castagnola M (2007) Proteomic analysis of salivary acidic proline-rich proteins in human preterm and at-tem newborns. J Proteome Res 6:1371–1377CrossRef

Titel: Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome
verfasst von: Donato Rigante
Rosanna Inzitari
Maurizio Carone
Chiara Fanali
Achille Stabile
Tiziana Cabras
Ettore Capoluongo
Stefania Gaspari
Giuseppe Barone
Massimo Castagnola
Publikationsdatum: 01.06.2008
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 8/2008
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-008-0524-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2008

Exposition to chickenpox of two children with autoinflammatory syndromes under treatment with anakinra

Acute dermatomyositis associated with generalized subcutaneous edema

The effects of weightbath traction hydrotherapy as a component of complex physical therapy in disorders of the cervical and lumbar spine: a controlled pilot study with follow-up

Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis

Early Rheumatoid Arthritis in Italy: study of incidence based on a two-level strategy in a sub-area of Florence (Scandicci-Le Signe)

Decreased levels of soluble receptor for advanced glycation end products in patients with primary Sjögren’s syndrome

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin