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27.06.2023 | Short Report

Cortical high-flow sign on arterial spin labeling: a novel biomarker for IDH-mutation and 1p/19q-codeletion status in diffuse gliomas without intense contrast enhancement

verfasst von: Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Yuhei Sangatsuda, Yutaka Fujioka, Izumi Kinoshita, Makoto Obara, Koji Yoshimoto, Kousei Ishigami

Erschienen in: Neuroradiology | Ausgabe 9/2023

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Abstract

This study aimed to investigate whether arterial spin labeling (ASL) features allow differentiation of oligodendroglioma, IDH-mutant and 1p/19q-codeleted (IDHm-codel) from diffuse glioma with IDH-wildtype (IDHw) or astrocytoma, IDH-mutant (IDHm-noncodel). Participants comprised 71 adult patients with pathologically confirmed diffuse glioma, classified as IDHw, IDHm-noncodel, or IDHm-codel. Subtraction images were generated from paired-control/label images on ASL and used to assess the presence of a cortical high-flow sign. The cortical high-flow sign was defined as increased ASL signal intensity within the tumor-affecting cerebral cortex compared with normal-appearing cortex. Regions without contrast enhancement on conventional MR imaging were targeted. The frequency of the cortical high-flow sign on ASL was compared among IDHw, IDHm-noncodel, and IDHm-codel. As a result, the frequency of the cortical high-flow sign was significantly higher for IDHm-codel than for IDHw or IDHm-noncodel. In conclusion, the cortical high-flow sign could represent a hallmark of oligodendroglioma, IDH-mutant, and 1p/19q-codeleted without intense contrast enhancement.
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Metadaten
Titel
Cortical high-flow sign on arterial spin labeling: a novel biomarker for IDH-mutation and 1p/19q-codeletion status in diffuse gliomas without intense contrast enhancement
verfasst von
Koji Yamashita
Osamu Togao
Kazufumi Kikuchi
Daisuke Kuga
Yuhei Sangatsuda
Yutaka Fujioka
Izumi Kinoshita
Makoto Obara
Koji Yoshimoto
Kousei Ishigami
Publikationsdatum
27.06.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 9/2023
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-023-03186-x

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