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01.12.2014 | Original Research | Ausgabe 2/2014 Open Access

Infectious Diseases and Therapy 2/2014

Cost and Impact on Patient Length of Stay of Rapid Molecular Testing for Clostridium difficile

Zeitschrift:
Infectious Diseases and Therapy > Ausgabe 2/2014
Autoren:
Bernadette Sewell, Eugene Rees, Ian Thomas, Chin Lye Ch’ng, Mike Isaac, Nidhika Berry
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s40121-014-0034-x) contains supplementary material, which is available to authorized users.

Abstract

Introduction

A study was performed to assess the cost of a rapid molecular assay (PCR) for diagnosis of Clostridium difficile infection (CDI) and the impact of its routine use on patient length of stay (LOS) in comparison with cell culture cytotoxin neutralization assay (CCNA).

Methods

From March 2011 to September 2011, Xpert® C. difficile (Cepheid, Sunnyvale, CA, USA) PCR was used on patients with suspicion of CDI in two acute care hospitals in Abertawe Bro Morgannwg University Health Board, Swansea, Wales, UK. Test results were used for patient management. LOS and time to reportable result were compared for negative and positive prospective patients tested by PCR and historic control patients tested by CCNA during March 2010 to September 2010. Tests were priced using micro-costing and a cost comparison analysis was undertaken.

Results

In total, 506 patients were included. Time to reportable result for PCR samples was 1.53 h compared to 46.54 h for CCNA negatives and 22.45 h for CCNA positives. Patients tested by CCNA stayed 4.88 days longer in hospital compared to PCR patients if they tested positive and 7.03 days if tests were negative. The mean reduction in LOS observed in our study has the potential to generate cost savings of up to £2,292.62 for every patient with suspected CDI, if samples were to be tested routinely with PCR instead of CCNA.

Conclusion

A rapid molecular test for C. difficile in an acute hospital setting produced quick results that led to a decrease in LOS compared to historic CCNA control patients. This could result in considerable savings through reduced excess inpatient days.
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