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15.02.2018 | Gastrointestinal | Ausgabe 7/2018

European Radiology 7/2018

Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?

Zeitschrift:
European Radiology > Ausgabe 7/2018
Autoren:
Yanyan Xu, Qiaoyu Xu, Hongliang Sun, Tongxi Liu, Kaining Shi, Wu Wang

Abstract

Purpose

To evaluate the diagnostic potential of DW-MRI relative parameters for differentiation of rectal cancers with different Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation status.

Methods

Fifty-one patients with rectal cancer underwent diffusion-weighted MR imaging with eight b values. ADCs (including Max-ADC, Min-ADC and Mean-ADC) and IVIM parameters (D, pure diffusion; f, perfusion fraction; D*, pseudodiffusion coefficient) were respectively calculated by mono- and bi-exponential analysis. Patients were stratified into two groups: KRAS wild type and mutant. The DW-MRI-derived parameters between the KRAS wild-type group and KRAS mutant group were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) analysis of discrimination between KRAS wild-type and KRAS mutant rectal cancer was performed for the DW-MRI-derived parameters.

Results

Max-ADC, Mean-ADC and D values were significantly lower in the KRAS mutant group than in the KRAS wild-type group, whereas a higher D* value was demonstrated in the KRAS mutant group. According to the ROC curve, Mean-ADC and D* values showed moderate diagnostic significance with the AUC values of 0.756 and 0.710, respectively. The cut-off values for Mean-ADC and D* were 1.43 × 10-3mm2/s and 26.58 × 10-3mm2/s, respectively.

Conclusion

Rectal cancers had distinctive diffusion/perfusion characteristics in different KRAS mutation statuses. The DW-MRI-derived parameters, specifically Mean-ADC and D*, show a moderate diagnostic significance for KRAS status.

Key Points

• Rectal cancers with different KRAS mutation statuses demonstrated distinctive diffusion/perfusion characteristics.
• Max-ADC, Mean-ADC and D values were lower in the KRAS mutant group.
• A higher D* value was demonstrated in the KRAS mutant group.
• IVIM-DW MRI may potentially help preoperative KRAS mutant status prediction.

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