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Erschienen in: The International Journal of Cardiovascular Imaging 12/2019

18.07.2019 | Original Paper

Could two-dimensional radial strain be considered as a novel tool to identify pre-clinical hypertrophic cardiomyopathy mutation carriers?

verfasst von: Gloria Maria Santambrogio, Alessandro Maloberti, Paola Vallerio, Angelica Peritore, Francesca Spanò, Lucia Occhi, Francesco Musca, Oriana Belli, Benedetta De Chiara, Francesca Casadei, Rita Facchetti, Fabio Turazza, Emanuela Manfredini, Cristina Giannattasio, Antonella Moreo

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 12/2019

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Abstract

Treatment of overt form of hypertrophic cardiomyopathy (HCM) is often unsuccessful. Efforts are focused on a possible early identification in order to prevent or delaying the development of hypertrophy. Our aim was to find an echocardiographic marker able to distinguish mutation carriers without left ventricular hypertrophy (LVH) from healthy subjects. We evaluated 28 patients, members of eight families. Three types of mutation were recognized: MYBPC3 (five families), MYH7 (two families) and TNNT2 (one family). According to genetic (G) and phenotypic (Ph) features, patients were divided in three groups: Group A (10 patients), mutation carriers with LVH (G+/Ph+); Group B (9 patients), mutation carriers without LVH (G+/Ph−); Group C (9 patients), healthy subjects (G−/Ph−). Echocardiography examination was performed acquiring standard 2D, DTI and 2D-strain imaging. Global longitudinal strain (GLS) and global radial strain (GRS) at basal and mid-level were measured. GRS was significantly different between group B and C at basal level (32.18% ± 9.6 vs. 44.59% ± 12.67 respectively; p-value < 0.0001). In basal posterior and basal inferior segments this difference was particularly evident. ROC curves showed for both the involved segments good AUCs (0.931 and 0.861 for basal posterior and inferior GRS respectively) with the best predictive cut-off for basal posterior GRS at 43.65%, while it was 38.4% for basal inferior GRS. Conversely, GLS values were similar in the three group. 2D longitudinal strain is a valid technique to study HCM. Radial strain and particularly basal posterior and inferior segmental reduction could be able to identify mutation carriers in a pre-clinical phase of disease.
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Metadaten
Titel
Could two-dimensional radial strain be considered as a novel tool to identify pre-clinical hypertrophic cardiomyopathy mutation carriers?
verfasst von
Gloria Maria Santambrogio
Alessandro Maloberti
Paola Vallerio
Angelica Peritore
Francesca Spanò
Lucia Occhi
Francesco Musca
Oriana Belli
Benedetta De Chiara
Francesca Casadei
Rita Facchetti
Fabio Turazza
Emanuela Manfredini
Cristina Giannattasio
Antonella Moreo
Publikationsdatum
18.07.2019
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 12/2019
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-019-01668-9

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