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Rheumatology International

Erschienen in:

14.07.2020 | COVID-19 | Review Zur Zeit gratis

Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment

verfasst von: Sanket Shah, Debashish Danda, Chengappa Kavadichanda, Saibal Das, M. B. Adarsh, Vir Singh Negi

Erschienen in: Rheumatology International | Ausgabe 10/2020

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Abstract

The coronavirus disease-2019 (COVID-19) pandemic is likely to pose new challenges to the rheumatology community in the near and distant future. Some of the challenges, like the severity of COVID-19 among patients on immunosuppressive agents, are predictable and are being evaluated with great care and effort across the globe. A few others, such as atypical manifestations of COVID-19 mimicking rheumatic musculoskeletal diseases (RMDs) are being reported. Like in many other viral infections, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can potentially lead to an array of rheumatological and autoimmune manifestations by molecular mimicry (cross-reacting epitope between the virus and the host), bystander killing (virus-specific CD8 + T cells migrating to the target tissues and exerting cytotoxicity), epitope spreading, viral persistence (polyclonal activation due to the constant presence of viral antigens driving immune-mediated injury) and formation of neutrophil extracellular traps. In addition, the myriad of antiviral drugs presently being tried in the treatment of COVID-19 can result in several rheumatic musculoskeletal adverse effects. In this review, we have addressed the possible spectrum and mechanisms of various autoimmune and rheumatic musculoskeletal manifestations that can be precipitated by COVID-19 infection, its therapy, and the preventive strategies to contain the infection.

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Titel: Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment
verfasst von: Sanket Shah
Debashish Danda
Chengappa Kavadichanda
Saibal Das
M. B. Adarsh
Vir Singh Negi
Publikationsdatum: 14.07.2020
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: Rheumatology International / Ausgabe 10/2020
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-020-04639-9

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