Background
NCT Number | Title | Phase | Sponsor/Collaborators |
---|---|---|---|
NCT02097641 | Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) | Phase 2 | National Heart, Lung, and Blood Institute (NHLBI) Massachusetts General Hospital Stanford University University of Pittsburgh University of Minnesota Ohio State University University of California, San Francisco |
NCT00957931 | Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs | Phase 2 | Stanford University University of Minnesota University of Alabama at Birmingham |
NCT01771913 | Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose-Derived Stem Cells (ADSC) Enriched Fat Grafts | Phase 2 | University of Sao Paulo |
NCT01909154 | Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia (CME-LEM1) | Phase 1 | Puerta de Hierro University Hospital |
NCT03102879 | Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration | Phase 1 Phase 2 | Universidad de los Andes, Chile Cells for Cells, Chile |
NCT02467387 | A Study to Assess the Effect of Intravenous Dose of (aMBMC) to Subjects With Non-ischemic Heart Failure | N/A | CardioCell LLC Stemedica Cell Technologies, Inc |
NCT02387749 | Effect Of Mesenchymal Stem Cells Transfusion on the Diabetic Peripheral Neuropathy Patients | N/A | Cairo University |
NCT01932164 | Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients | N/A | Hospital Sirio-Libanes |
NCT02481440 | Repeated Subarachnoid Administrations of hUC-MSCs in Treating SCI | Phase 1 Phase 2 | Third Affiliated Hospital, Sun Yat-Sen University, China |
NCT02165904 | Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI | Phase 1 | Emory University |
NCT02330978 | Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma | Phase 1 | University of Sao Paulo |
NCT01183728 NCT01586312 | Treatment of Knee Osteoarthritis With Autologous/ Allogenic Mesenchymal Stem Cells | Phase 1 Phase 2 | Red de Terapia Celular Fundacion Teknon, Centro Medico Teknon, Barcelona University of Valladolid |
NCT02037204 | IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee | Phase 1 Phase 2 | UMC Utrecht |
NCT02958267 | Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee | Phase 2 | OhioHealth |
NCT00587990 | Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) | Phase 1 Phase 2 | National Heart, Lung, and Blood Institute (NHLBI) Johns Hopkins University Specialized Center for Cell Based Therapy The Emmes Company, LLC University of Miami |
NCT01385644 | A Study to Evaluate the Potential Role of Mesenchymal Stem Cells in the Treatment of Idiopathic Pulmonary Fibrosis | Phase 1 | The Prince Charles Hospital Mater Medical Research Institute |
NCT02509156 | Stem Cell Injection in Cancer Survivors | Phase 1 | The University of Texas Health Science Center, Houston National Heart, Lung, and Blood Institute (NHLBI) |
NCT02379442 | Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids | Phase 1 Phase 2 | National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health Clinical Center (CC) |
NCT01087996 | The Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (The POSEIDON-Pilot Study) | Phase 1 Phase 2 | University of Miami National Heart, Lung, and Blood Institute (NHLBI) The Emmes Company, LLC |
NCT02013674 | The TRansendocardial Stem Cell Injection Delivery Effects on Neomyogenesis Study (The TRIDENT Study) | Phase 2 | The Emmes Company, LLC University of Miami |
NCT01392625 | PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study) | Phase 1 Phase 2 | National Heart, Lung, and Blood Institute (NHLBI) University of Miami |
NCT00768066 | The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT) | Phase 1 Phase 2 | University of Miami The Emmes Company, LLC |
NCT00629018 | Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy | Phase 2 | University Medical Centre Ljubljana Blood Transfusion Centre of Slovenia Stanford University |
NCT00927784 | Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD | Phase 2 | Icahn School of Medicine at Mount Sinai National Heart, Lung, and Blood Institute (NHLBI) Angioblast Systems |
Challenges in technology transfer of MSCs from bench to bedside
Immunocompatibility of MSCs
Stemness stability and differentiation of MSCs
Abbreviation | Names | Functional description | References |
---|---|---|---|
HMGB1 | High Mobility Group Box 1 | Interacts with SDF-1 and CXCR4; required for tissue repairment | [30] |
KLF2 | Krüppel-like Factor 2 | Enhances MSC proliferation; required for the maintenance of stemness | [31] |
MCM2 | Minichromosome maintenance marker 2 | Required for cell division and DNA replication | [32] |
CCNA2 | Cyclin A2 | Regulates cell cycle | [33] |
PCNA | Proliferating cell nuclear antigen | Recruits and retains many enzymes required for DNA replication and repairment | [34] |
POLA1 | DNA Polymerase Alpha 1 | Required for DNA replication | [35] |
POLD1 | DNA Polymerase Delta 1 | Required for DNA replication | [36] |
RFC4 | replication factor C subunit 4 | Required for DNA replication | [37] |
MAD2L1 | mitotic arrest-deficient 2 like 1 | Executes mitotic checkpoint | [38] |
CDK1 | Cyclin-Dependent Kinase 1 | A catalytic subunit of a protein kinase complex that induces cell entry into mitosis | [39] |
CCNB1 | Cyclin B1 | Predominantly expressed in the G2/M phase of cell division | [40] |
CDC45 | Cell Division Cycle 45 | An important component of the replication fork, in DNA unwinding | [41] |
TUBA1B | Tubulin Alpha 1b | Mitosis, cell movement, intracellular movement, and other biological processes | [42] |
E2F1 | E2F Transcription Factor 1 | Promotes proliferation or apoptosis in response to DNA damage | [43] |
BIRC5 | Baculoviral IAP Repeat Containing 5 | Regulates apoptosis | [44] |
BLM | Bloom syndrome, RecQ helicase-like | Maintains genome integrity | [45] |
ITGAV | Integrin Subunit Alpha V | Belongs to α-V integrin family, required for cell surface adhesion | [46] |
MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A | Required for chromosomes alignment at metaphase plate | [47] |
Heterogeneity of MSCs
Directed migratory capacity of MSCs
Limited expansion of MSCs
Effective components of MSC treatments
Attempts to improve the therapeutic outcomes of MSCs
Biomaterial strategies to maintain more homogeneous MSCs
Biomaterial properties | Biomaterial | MSCs Source | Experiment model | MSCs function | References |
---|---|---|---|---|---|
Dimensionality | 3D alginate micro-encapsulation versus 2D TCP | Human bone marrow | In vitro coculture with rat hippocampal slice | Reduced TNF-α and enhanced PGE-2 in the coculture slice | [108] |
3D alginate hydrogel versus 2D TCP | Human adipose tissue | In vitro | Enhanced potential of suppressing the proliferation of PBMCs | [109] | |
HA hydrogel encapsulation versus free cells | Rat bone marrow | In vivo implantation into rat SCI model | Encapsulated MSCs reduced M1 macrophages | [110] | |
Stiffness | Fibrin hydrogel | Human bone marrow | In vitro | Changed elastic modulus of hydrogel and protein secretion levels of VEGF and PGE-2 by MSCs | [111] |
Electrospun PCL fibrous scaffolds with random, aligned, and mesh-like fiber alignment | Rat adipose tissue | In vitro | MSCs on mesh-like fibers had the greatest potential of immunomodulation | [112] | |
Topographical cues: fiber alignment | Electrospun PLLA fibrous scaffolds with random or aligned fiber alignment | Human adipose tissue | In vitro | MSCs on aligned fibers had enhanced expression and secretion level of TSG-6 and COX-2 | [113] |
Ti-alloy disks with macro–micro-nanoscale-roughened surface or smooth surface | Human | In vitro | MSCs on rough surface had reduced secretion levels of proinflammatory gene expression | [114] | |
Topographical cues: surface roughness | Biphasic calcium phosphate bioceramics with micro-nanoscale-roughened surface or smooth surface | Mouse bone marrow | In vitro | MSCs on rough surface had reduced expression levels of proinflammatory cytokines | [115] |
Topographical cues: surface structure | Thermoplastic polyurethane plates with grid-like cavities or no-structure | Human bone marrow | In vitro | MSCs on grid-like structure had enhanced secretion levels of PGE-2 and IL-1RA | [116] |
Biochemistry | HA with different molecular weights: 1.6 MDa, 150 kDa, or 7.5 kDa | Human bone marrow | In vitro | Molecular weight of HA had negligible effect on MSC expression levels of immune modulators | [117] |
Micro-structure | Type-I collagen hydrogel, sponge and membrane | Neonatal rabbit bone marrow | In vitro | MSCs in a hydrogel that has the smallest pore size showed the greatest suppressive effect on the proliferation of PBMCs | [118] |
Genetic modification to produce MSCs with desired biologic function
Viral DNA transduction and mRNA/DNA transfection
Delivery system | Administration route | Sponsor | Indication | Development phase | Status | NCT number |
---|---|---|---|---|---|---|
MSCs secreting IFN-β | Intraperitoneal | M.D. Anderson Cancer Center, Dallas TX | Ovarian cancer | Phase 1 | Active, not recruiting | NCT02530047 |
MV-NIS infected adipose tissue–derived MSCs | Intraperitoneal | Mayo Clinic, Rochester MN | Recurrent ovarian cancer | Phase 1/2 | Recruiting | NCT02068794 |
Bone marrow-derived autologous MSCs infected with ICOVIR5, an oncolytic adenovirus (CELYVIR) | Intravenous | Hospital Infantil Universitario Niño Jesús, Madrid, Spain | Metastatic and refractory solid tumors | Phase 1/2 | Completed | NCT01844661 |
MSCs genetically modified to express TRAIL | Intravenous | University College, London | Lung adenocarcinoma | Phase 1/2 | Recruiting | NCT03298763 |
Autologous human MSCs genetically modified to express HSV-TK | Intravenous | Apceth GmbH & Co. KG, Germany | Advanced gastrointestinal cancer | Phase 1/2 | Completed | 2012–003,741-15 (EudraCT number) |
CRISPR-Cas9 technology to obtain highly homogeneous MSCs
Source of MSCs | Gene | Outcome | References |
---|---|---|---|
Human umbilical cord-derived MSCs | MCP-1/CCL2 | CCL2-overexpressing hUC-MSCs showed better functional recovery relative to naïve hUC-MSCs, promoting subsequent endogenous brain repair | [134] |
Human pancreatic ductal tissue MSCs | PTEN gene | PTEN mRNA synthesized in vitro is capable of being applied to a MSC-mediated anticancer strategy for the treatment of glioblastoma patients | [135] |
Mouse bone marrow MSCs | SV40T into a safe harboring site at Rosa26 locus | CRISPR/Cas9 HDR-mediated immortalization of BMSCs can be more effectively reversed than that of retrovirus-mediated random integrations | [136] |
Human bone marrow MSCs | Promotor of ectodysplasin (EDA) | After transfection with sgRNA-guided dCas9-E, the BM-MSCs acquired significantly higher transcription and expression of EDA by doxycycline (Dox) induction | [137] |
Mouse bone marrow-derived MSCs | IL-10 | Transplantation of CRISPR system engineered IL10-overexpressing bone marrow-derived MSCs for the treatment of myocardial infarction in diabetic mice | [138] |
Rat bone marrow MSCs | Smad7 | Smad7-MSCs is effective in treating liver fibrosis in the CCl4-induced liver cirrhosis model via inhibition of TGF-β1 signaling pathway | [139] |
Human mesenchymal stem cells | First intron of the PPP1R12C gene | exogenous gene hFIX was effectively expressed following site‑specific targeting into the AAVS1 locus in MSCs; MSCs may be used as potential cell carriers for gene therapy of hemophilia B | [140] |
Immortalized human bone marrow MSC cell line (ATCC PCS-500–041) | PUMILIO2 (PUM2) | Depletion of PUM2 blocks MSC adipogenesis and enhances osteogenesis. PUM2 works as a negative regulator on the 3′ UTRs of JAK2 and RUNX2 via direct binding. CRISPR/CAS9-mediated gene silencing of Pum2 inhibited lipid accumulation and excessive bone formation | [141] |
Human bone marrow-MSCs | Platelet-derived growth factor B (PDGF-B) | PDGFB-MSCs increased anti-apoptotic signaling and exhibited enhanced survival and expansion after transplantation, resulting in an enlarged humanized niche cell pool that provide a better humanized microenvironment to facilitate superior engraftment and proliferation of human hematopoietic cells | [142] |
“Priming” MSCs with small molecules to exogenously boost their therapeutic function
Stimuli | Source MSCs | Model/disease | In vivo/in vitro | Results | References |
---|---|---|---|---|---|
IFN-γ | Bone marrow | graft-versus-host disease (GVHD) | In vivo | IFN-γ primed MSCs significantly reduced the symptoms of GVHD in NOD-SCID mice, thereby increasing survival rate when compared with naïve MSC-infused mice | [146] |
IFN-γ | Bone marrow | – | In vitro | Inhibited T cell effector function through the ligands for PD1 and Th1 cytokines production | [148] |
IFN-γ | Bone marrow | IDO1, which depletes tryptophan necessary to support proliferation of activated T cells | In vitro | MSCs priming causes chromatin remodeling at the IDO1 promoter, that this alteration is maintained during processing commonly used to prepare MSCs for clinical use and that, once primed, MSCs are poised for IDO1 expression even in the absence of cytokines | [149] |
IFN-γ | Bone marrow | – | In vitro | Xenotransplantation of IFN-γ-pretreated human MSCs induces mouse calvarial bone regeneration | [150] |
IFN-γ | Bone marrow | DSS-induced colitis model | In vitro/ in vivo (mice) | Attenuated development of colitis, reduced pro-inflammatory cytokine levels in colon and increased migration potential | [151] |
IFN-γ | Umbilical cord | – | In vitro | Increased suppression of NK cells and reduced NK-mediated cytotoxicity | [152] |
IL-1β | Umbilical cord | DSS-induced colitis model | In vitro/ in vivo (mice) | Attenuated the development of murine colitis, increased migration potential to inflammatory sites by CXCR4 upregulation | [153] |
TNF-α and LPS | Bone marrow | – | In vitro | Increased alkaline phosphate activity and bone mineralization | [154] |
IL-17A | Bone marrow | – | In vitro | Increased suppressive potential of T cell proliferation correlated with increased IL-6, inhibited surface CD25 and Th1 cytokines expression, and induced iTregs | [155] |
5% O2 | Wharton’s jelly | – | In vitro | Conditioned-medium increased migration and tube formation in vitro, partially reduced by prior inhibition autophagy | [156] |
2.5% O2 | Bone marrow | Radiation-induced lung injury model | In vitro/ in vivo (mice) | Upregulated HIF-1α, increased survival and the antioxidant ability, increased efficiency in the treatment of radiation-induced lung injury | [157] |
2–2.5% O2 | Placenta | – | In vitro | Upregulated glucose transporters, adhesion molecules and increased angiogenic potential | [156] |
2% O2 | Adipose tissue | Murine hindlimb ischemia model | In vitro/ in vivo (mice) | Enhanced proliferation, survival, and angiogenic cytokine secretion in vivo | [158] |
1.5% O2 | Bone marrow | Bleomycin-induced pulmonary fibrosis model | In vitro/ in vivo (mice) | Improved pulmonary functions and reduced inflammatory and fibrotic mediators in vivo | [159] |
1% O2 | Human cord blood | – | In vitro | Increased the survival and pro-angiogenic capacity in ischemia-like environment, induced anti-apoptotic mechanisms, and increased VEGF secretion | [160] |
1% O2 | Bone marrow | Intramuscular injection into immune-deficient mice | In vitro/ in vivo (mice) | Reduced cell death under serum-deprivation conditions, decreased cytochrome c and HO-1 levels, enhanced survival in vivo | [161] |
3D cell culture in collagen-hydrogel scaffold | Umbilical Cord | – | In vitro | Induced chondrogenesis differentiation by increasing expressions of collagen II, aggrecan, COMPS | [162] |
3D cell culture in chitosan scaffold | Bone marrow (rat) | – | In vitro | Induced chondrogenesis differentiation by increased production of collagen type II | [163] |
3D cell culture of composite combining an affinity peptide sequence (E7) and hydrogel | Bone marrow (rat) | – | In vitro | Increased cell survival, matrix production, and improved chondrogenic differentiation ability | [164] |
3D cell culture in hydrogel | bone marrow (Human) | Rat myocardial infarction model | In vitro/ in vivo | The epicardial placement of MSC-loaded POx hydrogels promoted the recovery of cardiac function and structure with reduced interstitial fibrosis and improved neovascular formation | [165] |
Encapsulation in hydrogel | Bone marrow (rat) | Diabetic ulcers model | In vitro/ in vivo (rats) | Promoted granulation tissue formation, angiogenesis, extracellular matrix secretion, wound contraction, and re-epithelialization | [166] |
High glucose concentration in the culture medium | Bone marrow | In vitro | Decreased chondrogenic capacity | [167] | |
Medium from cardiomyocytes exposed to oxidative stress and high glucose | Bone marrow (diabetic mouse) | Diabetes induced with streptozotocin model | In vitro/ in vivo (mice) | Enhanced survival, proliferation and angiogenic ability, increased the ability to improve function in a diabetic heart | [168] |
Spheroid formation (different techniques) | Bone marrow | In vitro | Enhanced homogenous cellular aggregates formation and improved osteogenic differentiation (low attachment plates) | [169] | |
Spheroids formation (hanging-drop) | Bone marrow | Zymosan-induced peritonitis model | In vitro/ in vivo (mice) | Expressed high levels of anti-inflammatory (TSG-6 and STC-1) and anti-tumorigenic molecules compared to 2D culture, suppressed inflammation in vivo | [170] |
matrilin-3-primed spheroid generation | Adipose tissue | intervertebral disc (IVD) degeneration | In vitro/ in vivo (rabbit) | Priming MSCs with matrilin-3 and spheroid formation could be an effective strategy to overcome the challenges associated with the use of MSCs for the treatment of IVD degeneration | [171] |
Spheroids formation (hanging drop) | Cord blood | Hindlimb ischemia model | In vitro/ in vivo (mice) | Improved engraftment; increased the number of microvessels and smooth muscle α-actin-positive vessels | [172] |
Utilize the MSCs secretome as a drug delivery platform for treatment
Advances and perspectives to overcome challenges in MSC clinical application
Artificial intelligence (AI) in MSC treatment
Engineered MSC-EVs for treatment
NCT number | Title | Status | Condition | Phase | Start date |
---|---|---|---|---|---|
NCT04173650 | MSC EVs in Dystrophic Epidermolysis Bullosa | Not yet recruiting | Dystrophic Epidermolysis Bullosa | Phase 1 Phase 2 | Sep-2020 |
NCT04276987 | A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia | Completed | Coronavirus | Phase 1 | Feb-2020 |
NCT02138331 | Effect of Microvesicles and Exosomes Therapy on cell Mass in Type I Diabetes Mellitus (T1DM) | Unknown status | Diabetes Mellitus Type 1 | Phase 2 Phase 3 | Apr-2014 |
NCT04313647 | A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers | Recruiting | Healthy | Phase 1 | Mar-2020 |
NCT03384433 | Allogenic Mesenchymal Stem Cell-Derived Exosome in Patients With Acute Ischemic Stroke | Recruiting | Cerebrovascular Disorders | Phase 1 Phase 2 | Apr-2019 |
NCT04223622 | Effects of ASC Secretome on Human Osteochondral Explants | Not yet recruiting | Osteoarthritis | - | Feb-2020 |
NCT04213248 | Effect of UMSCs-Derived Exosomes on Dry Eye in Patients With cGVHD | Recruiting | Dry Eye | Phase 1 Phase 2 | Feb-2020 |
NCT03437759 | MSC-Exos Promote Healing of MHs | Recruiting | Macular Holes | Early Phase 1 | Mar-2017 |
NCT04356300 | Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfunction Syndrome After Surgical Repair of Acute Type A Aortic Dissection | Not yet recruiting | Multiple Organ Failure | Not Applicable | Sep-2020 |
NCT04388982 | The Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease | Recruiting | Alzheimer Disease | Phase 1 Phase 2 | Jul-2020 |
NCT03608631 | Exosomes in Treating Participants with Metastatic Pancreas Cancer with KrasG12D Mutation | Not yet recruiting | Metastatic Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer | Phase 1 | Mar-2020 |
NCT04602442 | Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia | Enrolling by invitation | Covid19 | Phase 2 | Oct-2020 |
NCT04491240 | Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia | Completed | Covid19 | Phase 1 Phase 2 | July 2020 |
NCT04602104 | A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS | Not yet recruiting | Acute Respiratory Distress Syndrome | Phase 1 Phase 2 | Oct-2020 |
NCT03857841 | A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD | Recruiting | Bronchopulmonary Dysplasia | Phase 1 | June-2019 |
MSC usage for pandemic diseases such as COVID-19
Study name | NCT number | Starting date | Phase | Key findings/study status |
---|---|---|---|---|
Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome | NCT04366063 | April 2020 | 2–3 | Recruiting |
UC-MSCs in the treatment of novel coronavirus severe pneumonia | NCT04273646 | February 2020 | Not applicable | Not yet recruiting |
A pilot clinical study on inhalation of MSCs exosomes treating severe novel coronavirus pneumonia | NCT04276987 | February 2020 | 1 | Not yet recruiting |
UC-MSCs treatment for the 2019-novel coronavirus pneumonia | NCT04269525 | February 2020 | 2 | Recruiting |
Treatment with MSCs for severe corona virus disease 2019 | NCT04288102 | February 2020 | 1–2 | Not yet recruiting |
MSCs treatment for pneumonia patients infected with 2019 novel coronavirus | NCT04252118 | January 2020 | 1 | Recruiting |
Nest Cell ®Mesenchymal Stem Cell to Treat Patients with Severe COVID19 Pneumonia | NCT04315987 | April 2020 | 1 | Not yet recruiting |
Treatment of COVID19 Patients Using Wharton’s Jelly Mesenchymal Stem Cells | NCT04313322 | March 2020 | 1 | Recruiting |
Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells | NCT04302519 | March 2020 | Early phase 1 | Not yet recruiting |
Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID19 Patients | NCT04336254 | April 2020 | 1 and 2 | Recruiting |
Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID19 Pneumonia | NCT04339660 | February 2020 | 1 and 2 | Recruiting |
Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Severe Patients With Coronavirus Disease 2019 (COVID19) | NCT04346368 | April 2020 | 1 and 2 | Not yet recruiting |
Adipose Mesenchymal Cells for Abatement of SARS CoV-2 Respiratory Compromise in COVID-19 Disease | NCT04352803 | April 2020 | 1 | Not yet recruiting |
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HBadMSCs) to Provide Protection Against COVID19 | NCT04349631 | May 2020 | 2 | Enrolling by invitation |
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) (COVID19) (REALIST) | NCT03042143 | January 2019 | 1 and 2 | Recruiting |
Safety and Efficacy of Intravenous Wharton’s Jelly-Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome due to COVID19 | NCT04390152 | June 2020 | 1 and 2 | Not yet recruiting |
Treatment of COVID19 Associated Pneumonia with Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells | NCT04382547 | May 2020 | 1 and 2 | Not yet recruiting |
Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients with Severe Pneumonia due to COVID19 | NCT04366323 | April 2020 | 1 and 2 | Not yet recruiting |
Study of the Safety of Therapeutic Tx with Immunomodulatory MSC in Adults with COVID19 Infection Requiring Mechanical Ventilation | NCT04397796 | June 2020 | 1 | Not yet recruiting |
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients with Respiratory Distress to COVID19 | NCT04390139 | May 2020 | 1 and 2 | Recruiting |
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID19) Induced Acute Respiratory Distress Syndrome | NCT04377334 | May 2020 | 2 | Not yet Recruiting |
Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID19 | NCT04362189 | May 2020 | 3 | Not yet Recruiting |
Clinical Trial of Allogeneic Mesenchymal Cells from Umbilical Cord Tissue in Patients with COVID19 | NCT04366271 | May 2020 | 2 | Recruiting |
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Allogeneic Mesenchymal Stem Cell Therapy (HBadMSCs) to Provide Protection Against COVID19 | NCT04348435 | April 2020 | 2 | Enrolling by invitation |
Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 | NCT04371601 | March 2020 | 2 | Active not Recruiting |
Use of UC-MSCs for COVID19 Patients | NCT04355728 | April 2020 | Early Phase 1 | Recruiting |
Clinical Use of Stem Cells for the Treatment of COVID19 | NCT04392778 | April 2020 | 1 and 2 | Recruiting |
Study of the Safety of Therapeutic Tx with Immunomodulatory MSC in Adults with COVID19 Infection Requiring Mechanical Ventilation | NCT04397796 | June 2020 | 1 and 2 | Not yet Recruiting |
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients with Respiratory Distress to COVID19 | NCT04390139 | May 2020 | 1 | Recruiting |