Introduction
Methods
Study design and participants
Data collection
Statistical analysis
Results
Baseline characteristics of patients with COVID-19
Characteristic | Total (n = 214) | Non-ICU group (n = 161) | ICU group (n = 53) | P value |
---|---|---|---|---|
Sociodemographic | ||||
Age, median (IQR), years | 49.00 (39.00–56.00) | 46.00 (37.50–54.00) | 57.00 (50.50–75.50) | < 0.001 |
Male/female, n (%) | 117 (54.7)/97 (45.3) | 88 (54.7)/73 (45.3) | 29 (54.7)/24 (45.3) | 0.994 |
Chronic medical diseases | ||||
Hypertension, n (%) | 16 (7.5) | 11 (6.8) | 5 (9.4) | 0.746 |
Coronary heart disease, n (%) | 7 (3.3) | 3 (1.9) | 4 (7.5) | 0.116 |
Underlying pulmonary diseases, n (%) | 10 (4.7) | 4 (2.5) | 6 (11.3) | 0.023 |
Chronic liver or kidney disease, n (%) | 5 (2.3) | 3 (1.9) | 2 (3.8) | 0.599 |
Diabetes mellitus, n (%) | 24 (11.2) | 8 (5.0) | 16 (30.2) | < 0.001 |
Malignancy, n (%) | 2 (0.9) | 0 (0.0) | 2 (3.8) | 0.060 |
Signs and symptoms on hospital admission | ||||
Fever, n (%) | 112 (52.3) | 79 (49.1) | 33 (62.3) | 0.095 |
Chills, n (%) | 28 (13.1) | 19 (11.8) | 9 (17.0) | 0.332 |
Myalgia, n (%) | 26 (12.1) | 17 (10.6) | 9 (17.0) | 0.215 |
Fatigue, n (%) | 49 (22.9) | 29 (18.0) | 20 (37.7) | 0.003 |
Cough, n (%) | 137 (64.0) | 95 (59.0) | 42 (79.2) | 0.008 |
Expectoration, n (%) | 60 (28.0) | 39 (24.2) | 21 (39.6) | 0.030 |
Short of breath, n (%) | 41 (19.2) | 20 (12.4) | 21 (39.6) | < 0.001 |
Chest tightness, n (%) | 19 (8.9) | 11 (6.8) | 8 (15.1) | 0.120 |
Chest pain, n (%) | 6 (2.8) | 2 (1.2) | 4 (7.5) | 0.034 |
Anorexia, n (%) | 27 (12.6) | 18 (11.2) | 9 (17.0) | 0.270 |
Nausea or vomiting, n (%) | 9 (4.2) | 6 (3.7) | 3 (5.7) | 0.831 |
Abdominal pain, n (%) | 4 (1.9) | 2 (1.2) | 2 (3.8) | 0.257 |
Diarrhea, n (%) | 13 (6.1) | 10 (6.2) | 3 (5.7) | 1.000 |
Headache, n (%) | 21 (9.8) | 15 (9.3) | 6 (11.3) | 0.671 |
Dizziness, n (%) | 21 (9.8) | 14 (8.7) | 7 (13.2) | 0.338 |
Others | ||||
Onset of symptom to hospital admission, median (IQR), days | 6.00 (3.00–10.00) | 6.00 (3.00–10.00) | 7.00 (4.50–8.00) | 0.612 |
NCT of SARC-CoV-2, median (IQR), days | 17.00 (13.00–23.00) | 17.00 (13.00–23.00) | 21.00 (15.50–26.50) | 0.004 |
Length of hospital stay, median (IQR), days | 14.00 (12.00–22.00) | 13.00 (11.00–17.00) | 24.00 (14.50–37.00) | < 0.001 |
Onset of symptom to hospital discharge or death, median (IQR), days | 22.00 (18.00–29.00) | 22.00 (18.00–29.00) | 30.00 (22.50–43.50) | < 0.001 |
Laboratory findings of patients with COVID-19 on hospital admission
Characteristic | Normal range | Total (n = 214) | Non-ICU group (n = 161) | ICU group (n = 53) | P value |
---|---|---|---|---|---|
Blood routine | |||||
White blood cell, median (IQR), × 109/L | 3.50–9.50 | 5.20 (4.10–6.70) | 5.10 (4.10–6.60) | 5.40 (4.35–6.95) | 0.490 |
Neutrophil, median (IQR), × 109/L | 1.80–6.30 | 3.56 (2.58–4.88) | 3.46 (2.51–4.40) | 4.21 (2.97–5.66) | 0.006 |
Lymphocyte, median (IQR), × 109/L | 1.10–3.20 | 1.08 (0.80–1.53) | 1.20 (0.90–1.60) | 0.75 (0.55–1.04) | < 0.001 |
Monocyte, median (IQR), × 109/L | 3.00–10.00 | 0.37 (0.29–0.48) | 0.39 (0.31–0.48) | 0.33 (0.19–0.48) | 0.016 |
Platelet, median (IQR), × 109/L | 125.00–350.00 | 176.50 (138.00–236.25) | 186.00 (146.50–238.00) | 150.00 (118.00–229.50) | 0.045 |
Neutrophil, median (IQR), % | 40.00–75.00 | 69.15 (60.68–78.75) | 65.80 (58.70–73.45)) | 79.90 (70.05–84.90) | < 0.001 |
Lymphocyte, median (IQR), % | 20.00–50.00 | 22.65 (14.30–29.20) | 24.80 (17.95–30.65) | 13.50 (10.05–21.50) | < 0.001 |
Monocyte, median (IQR),% | 3.00–10.00 | 7.10 (5.50–9.20) | 7.30 (6.00–9.25) | 5.70 (3.90–8.45) | 0.001 |
NLR, median (IQR), % | NA | 3.05 (2.07–5.34) | 2.55 (1.85–4.09) | 5.94 (3.26–8.50) | < 0.001 |
Lymphocytopenia, n (%) | NA | 187 (87.4) | 136 (84.5) | 51 (96.2) | 0.025 |
Thrombopenia, n (%) | NA | 36 (16.8) | 21 (13.0) | 15 (28.3) | 0.011 |
Blood biochemistry | |||||
Urea nitrogen, median (IQR), mmol/L | 3.10–8.00 | 4.00 (3.20–5.20) | 3.90 (3.20–4.95) | 4.50 (3.05–5.90) | 0.160 |
Creatinine, median (IQR), mmol/L | 57.00–97.00 | 66.00 (55.00–75.25) | 66.00 (56.00–76.50) | 65.00 (50.00–75.00) | 0.435 |
TBil, median (IQR), umol/L | 0.00–26.00 | 9.60 (6.38–15.93) | 9.60 (5.95–16.05) | 10.00 (6.80–15.20) | 0.768 |
DBil, median (IQR), umol/L | 0.00–8.00 | 4.70 (3.28–6.40) | 4.50 (3.10–6.20) | 5.10 (3.65–8.15) | 0.033 |
ALT, median (IQR), U/L | 9.00–50.00 | 21.20 (14.68–35.13) | 19.70 (14.65–33.35) | 26.00 (13.55–39.30) | 0.218 |
AST, median (IQR), U/L | 15.00–40.00 | 23.50 (17.18–34.18) | 20.80 (16.50–28.70) | 34.00 (25.60–44.50) | < 0.001 |
CK, median (IQR), U/L | 50.00–310.00 | 62.00 (42.00–90.00) | 60.00 (42.00–84.05) | 77.00 (40.50–159.50) | 0.067 |
CKMB, median (IQR), U/L | 0.00–25.00 | 12.00 (10.00–16.00) | 12.00 (10.00–16.00) | 14.00 (9.90–17.00) | 0.530 |
HbA1c, median (IQR),% | 5.60 (5.30–5.90) | 5.50 (5.30–5.80) | 5.90 (5.60–7.15) | < 0.001 | |
Infection related parameters | |||||
CRP, median (IQR), mg/L | 0.00–8.00 | 11.63 (2.12–50.89) | 5.99 (1.72–20.43) | 81.05 (46.12–131.49) | < 0.001 |
PCT, median (IQR), ng/mL | < 0.046 | 0.04 (0.03–0.07) | 0.04 (0.03–0.06) | 0.09 (0.06–0.14) | < 0.001 |
Coagulation function | |||||
PT, median (IQR), s | 8.00–14.00 | 11.10 (10.60–11.43) | 11.00 (10.55–11.35) | 11.30 (10.65–11.80) | 0.019 |
APTT, median (IQR), s | 20.00–40.00 | 26.50 (24.50–29.30) | 26.10 (23.90–28.40) | 29.00 (26.30–33.50) | < 0.001 |
D-dimer, median (IQR), mg/L | 0.00–0.55 | 0.37 (0.20–0.60) | 0.28 (0.19–0.47) | 0.62 (0.44–1.30) | < 0.001 |
Lymphocyte subsets and cytokines of patients with COVID-19 on hospital admission
Characteristic | Normal range | Total (n = 214) | Non- ICU group (n = 161) | ICU group (n = 53) | P value |
---|---|---|---|---|---|
Lymphocyte classification | |||||
Lymphocyte, median (IQR), × 106/L | 1530.00–3700.00 | 936.50 (661.50–1323.25) | 1063.00 (767.50–1389.50) | 659.00 (480.50–885.50) | < 0.001 |
CD3+, median (IQR), × 106/L | 699.00–2540.00 | 632.50 (429.50–925.50) | 717.00 (544.00–973.00) | 417.00 (252.50–571.50) | < 0.001 |
CD4+, median (IQR), × 106/L | 410.00–1590.00 | 377.50 (265.75–536.00) | 432.00 (308.50–609.50) | 261.00 (153.50–351.50) | < 0.001 |
CD8+, median (IQR), × 106/L | 190.00–1140.00 | 242.50 (157.75–335.50) | 271.00 (193.00–382.50) | 140.00 (95.00–205.00) | < 0.001 |
CD19+, median (IQR), × 106/L | 90.00–660.00 | 128.00 (86.75–184.75) | 133.00 (90.50–209.00) | 109.00 (77.50–144.50) | 0.012 |
NK, median (IQR), × 106/L | 90.00–590.00 | 132.00 (86.75–211.00) | 143.00 (96.50–230.50) | 102.00 (65.50–166.00) | 0.002 |
CD3+, median (IQR),% | 55.00–84.00 | 68.09 (61.74–75.00) | 70.26 (64.23–75.48) | 62.59 (54.61–68.75) | < 0.001 |
CD4+, median (IQR),% | 31.00–60.00 | 39.30 (34.58–44.40) | 40.05 (35.87–44.93) | 37.78 (29.18–43.56) | 0.030 |
CD8+, median (IQR),% | 13.00–41.00 | 25.02 (20.28–30.41) | 25.96 (21.03–30.75) | 22.42 (17.52–29.01) | 0.009 |
CD19+, median (IQR),% | 6.00–25.00 | 14.54 (10.46–18.09) | 13.94 (9.99–17.14) | 17.48 (13.29–22.21) | < 0.001 |
NK, median (IQR),% | 5.00–27.00 | 15.00 (9.59–21.97) | 13.98 (9.11–20.85) | 18.64 (10.10–25.99) | 0.038 |
CD4+/CD8+, median (IQR) | 0.70–2.87 | 1.54 (1.20–2.05) | 1.54 (1.24–1.97) | 1.53 (1.12–2.43) | 0.649 |
Cytokine profiles | |||||
IL-4, median (IQR), pg/mL | 0.00–8.56 | 1.70 (1.33–2.38) | 1.70 (1.34–2.37) | 1.68 (1.26–2.45) | 0.573 |
IL-6, median (IQR), pg/mL | 0.00–5.40 | 4.15 (0.00–11.75) | 3.13 (0.00–6.69) | 18.08 (6.69–46.45) | < 0.001 |
IL-10, median (IQR), pg/mL | 0.00–12.90 | 2.72 (2.33–3.76) | 2.56 (2.23–3.08) | 3.83 (2.98–5.16) | < 0.001 |
IL-17, median (IQR), pg/mL | 0.00–21.40 | 1.21 (1.04–1.38) | 1.21 (1.04–1.39) | 1.18 (1.02–1.37) | 0.393 |
TNF-α, median (IQR), pg/mL | 0.00–16.50 | 3.39 (1.82–5.93) | 3.48 (1.86–6.25) | 3.05 (1.61–5.42) | 0.390 |
IFN-γ, median (IQR), pg/mL | 0.00–23.10 | 4.15 (1.77–8.28) | 4.05 (1.70–7.88) | 4.32 (2.32–8.72) | 0.295 |
Multivariate logistic regression model and ROC curve analysis for ICU admission
Variables | β | OR | 95% CI | P value |
---|---|---|---|---|
Age (years) | 0.065 | 1.067 | 1.034–1.101 | < 0.001 |
Diabetes mellitus (1 = yes, 0 = no) | 2.214 | 9.154 | 2.710–30.926 | < 0.001 |
CD3+ (× 106/L) | − 0.004 | 0.996 | 0.994–0.997 | < 0.001 |
IL-6 (pg/ml) | 1.006 | 1.000–1.013 | 0.039 | |
Constant | − 2.458 | 0.086 | – | 0.014 |
Predictor | AUC | P value | 95% CI | Cutoff value | Jordan index | Sensitivity (%) | Specificity |
---|---|---|---|---|---|---|---|
Age | 0.766 | < 0.001 | 0.689–0.844 | > 53.50 | 0.437 | 69.8 | 73.9 |
Diabetes mellitus | 0.626 | 0.006 | 0.532–0.720 | > 0.50 | 0.252 | 30.2 | 95.0 |
Lymphocyte | 0.780 | < 0.001 | 0.709–0.851 | < 840.00 | 0.456 | 73.6 | 72.0 |
CD3+ | 0.806 | < 0.001 | 0.737–0.874 | < 510.50 | 0.512 | 71.7 | 79.5 |
CD4+ | 0.776 | < 0.001 | 0.705–0.847 | < 357.50 | 0.426 | 77.4 | 65.2 |
CD8+ | 0.796 | < 0.001 | 0.721–0.872 | < 173.50 | 0.505 | 67.9 | 82.6 |
CD19+ | 0.616 | 0.012 | 0.533–0.699 | < 148.00 | 0.196 | 81.1 | 38.5 |
NK | 0.639 | 0.002 | 0.553–0.725 | < 134.50 | 0.270 | 71.7 | 55.3 |
IL-4 | 0.526 | 0.573 | 0.433–0.618 | < 1.27 | 0.096 | 26.4 | 83.2 |
IL-6 | 0.785 | < 0.001 | 0.705–0.864 | > 6.58 | 0.519 | 77.4 | 74.5 |
IL-10 | 0.760 | < 0.001 | 0.681–0.838 | > 2.95 | 0.494 | 77.4 | 72.0 |
IL-17 | 0.539 | 0.393 | 0.451–0.627 | < 1.27 | 0.096 | 69.8 | 39.8 |
TNF-α | 0.539 | 0.390 | 0.452–0.626 | < 8.40 | 0.099 | 96.2 | 13.7 |
IFN-γ | 0.548 | 0.295 | 0.460–0.636 | > 7.73 | 0.116 | 37.7 | 73.9 |
Combined predictor | 0.887 | < 0.001 | 0.837–0.937 | > 0.309 | 0.631 | 77.4 | 85.7 |
Lymphocyte subsets and cytokines of ICU COVID-19 patients
Characteristic | Total (n = 53) | Severe group (n = 37) | Critical group (n = 16) | Z value | P value |
---|---|---|---|---|---|
Lymphocyte classification | |||||
Lymphocyte, median (IQR), × 106/L | 659.00 (480.50–885.50) | 743.00 (517.00–965.50) | 547.00 (473.00–704.75) | − 1.792 | 0.073 |
CD3+, median (IQR), × 106/L | 417.00 (252.50–571.50) | 430.00 (327.00–602.00) | 327.00 (211.75–476.75) | − 1.482 | 0.138 |
CD4+, median (IQR), × 106/L | 261.00 (153.50–351.50) | 280.00 (173.00–380.50) | 211.00 (131.50–294.75) | − 1.782 | 0.075 |
CD8+, median (IQR), × 106/L | 140.00 (95.00–205.00) | 148.00 (95.00–234.50) | 120.00 (90.75–160.25) | − 1.298 | 0.194 |
CD19+, median (IQR), × 106/L | 109.00 (77.50–144.50) | 116.00 (86.00–146.00) | 99.00 (46.00–128.75) | − 1.579 | 0.114 |
NK, median (IQR), × 106/L | 102.00 (65.50–166.00) | 103.00 (77.50–175.00) | 87.00 (49.50–133.50) | − 1.298 | 0.194 |
CD3+, median (IQR),% | 62.59 (54.61–68.75) | 62.59 (56.71–68.28) | 61.37 (49.94–70.59) | − 0.019 | 0.985 |
CD4+, median (IQR),% | 37.78 (29.18–43.56) | 38.54 (30.89–43.93) | 30.14 (26.93–40.06) | − 1.376 | 0.169 |
CD8+, median (IQR),% | 22.42 (17.52–29.01) | 21.13 (17.32–27.49) | 22.86 (18.58–36.27) | 0.872 | 0.383 |
CD19+, median (IQR),% | 17.48 (13.29–22.21) | 17.00 (14.65–21.74) | 18.87 (11.86–22.82) | − 0.194 | 0.846 |
NK, median (IQR),% | 18.64 (10.10–25.99) | 16.68 (12.29–25.77) | 19.39 (9.23–26.18) | 0.039 | 0.969 |
CD4+/CD8+, median (IQR) | 1.53 (1.12–2.43) | 1.82 (1.20–2.34) | 1.24 (0.84–2.55) | − 1.066 | 0.287 |
Cytokine profiles | |||||
IL-4, median (IQR), pg/mL | 1.68 (1.26–2.45) | 1.55 (1.20–2.38) | 1.99 (1.32–2.50) | 1.027 | 0.304 |
IL-6, median (IQR), pg/mL | 18.08 (6.69–46.45) | 17.35 (6.69–43.62) | 21.89 (7.20–85.51) | 1.077 | 0.281 |
IL-10, median (IQR), pg/mL | 3.83 (2.98–5.16) | 3.55 (2.81–4.94) | 4.79 (3.23–6.25) | 1.705 | 0.088 |
IL-17, median (IQR), pg/mL | 1.18 (1.02–1.37) | 1.15 (1.00–1.33) | 1.20 (1.04–1.47) | 0.349 | 0.727 |
TNF-α, median (IQR), pg/mL | 3.05 (1.61–5.42) | 3.12 (1.36–5.59) | 2.93 (2.19–5.25) | 0.281 | 0.779 |
IFN-γ, median (IQR), pg/mL | 4.32 (2.32–8.72) | 5.18 (2.00–10.04) | 4.08 (2.35–7.44) | − 0.562 | 0.574 |
Characteristic | Total (n = 53) | Severe group (n = 37) | Critical group (n = 16) | Z value | P value |
---|---|---|---|---|---|
Lymphocyte classification | |||||
Lymphocyte, median (IQR), × 106/L | 597.00 (420.50–870.00) | 695.00 (423.00–902.00) | 535.00 (367.50–704.75) | − 1.395 | 0.163 |
CD3+, median (IQR), × 106/L | 399.00 (196.50–547.50) | 430.00 (211.00–590.00) | 327.00 (175.25–476.75) | − 1.085 | 0.278 |
CD4+, median (IQR), × 106/L | 243.00 (118.00–341.00) | 261.00 (131.50–377.00) | 211.00 (86.50–294.75) | − 1.279 | 0.201 |
CD8+, median (IQR), × 106/L | 140.00 (87.50–209.00) | 157.00 (89.00–227.50) | 117.50 (84.75–160.25) | − 1.143 | 0.253 |
CD19+, median (IQR), × 106/L | 103.00 (73.50–144.50) | 103.00 (80.00–146.00) | 99.00 (46.00–131.00) | − 1.163 | 0.245 |
NK, median (IQR), × 106/L | 103.00 (60.50–166.00) | 109.00 (67.50–168.50) | 87.00 (49.50–130.00) | − 1.424 | 0.154 |
CD3+, median (IQR),% | 61.33 (50.67–68.25) | 61.33 (50.96–67.90) | 61.37 (49.94–70.59) | 0.446 | 0.656 |
CD4+, median (IQR),% | 35.84 (28.26–42.69) | 36.04 (29.87–42.89) | 30.14 (26.93–40.06) | − 0.911 | 0.363 |
CD8+, median (IQR),% | 21.98 (16.61–28.62) | 21.10 (16.61–27.49) | 22.77 (16.09–36.27) | 0.581 | 0.561 |
CD19+, median (IQR),% | 17.92 (13.04–22.91) | 17.73 (14.38–22.93) | 18.87 (11.86–22.82) | − 0.271 | 0.786 |
NK, median (IQR),% | 19.28 (10.66–26.77) | 19.18 (13.41–27.32) | 19.39 (9.23–26.18) | − 0.542 | 0.587 |
CD4+/CD8+, median (IQR) | 1.53 (1.09–2.33) | 1.71 (1.12–2.08) | 1.23 (0.83–2.55) | 0.794 | 0.416 |
Cytokine profiles | |||||
IL-4, median (IQR), pg/mL | 1.73 (1.33–2.45) | 1.68 (1.32–2.45) | 1.98 (1.32–2.50) | 0.523 | 0.607 |
IL-6, median (IQR), pg/mL | 16.39 (4.53–49.63) | 11.61 (2.48–46.45) | 21.89 (7.20–85.51) | 1.437 | 0.151 |
IL-10, median (IQR), pg/mL | 3.76 (2.85–5.17) | 3.44 (2.70–5.17) | 4.79 (3.23–6.25) | 1.744 | 0.081 |
IL-17, median (IQR), pg/mL | 1.19 (1.04–1.40) | 1.18 (1.04–1.36) | 1.20 (1.04–1.47) | − 0.058 | 0.954 |
TNF-α, median (IQR), pg/mL | 3.52 (2.14–5.42) | 3.54 (1.92–5.59) | 2.93 (2.19–5.25) | − 0.203 | 0.839 |
IFN-γ, median (IQR), pg/mL | 5.18 (2.27–8.72) | 5.42 (1.95–9.81) | 4.08 (2.35–7.44) | − 0.668 | 0.504 |
Characteristic | Direct-ICU group (n = 33) | Late-ICU group (n = 20) | Z value | P value |
---|---|---|---|---|
Lymphocyte classification | ||||
Lymphocyte, median (IQR), × 106/L | 681.00 (480.50–965.50) | 578.50 (489.50–820.25) | − 0.706 | 0.480 |
CD3+, median (IQR), × 106/L | 430.00 (220.50–571.50) | 357.00 (264.00–573.50) | − 0.505 | 0.614 |
CD4+, median (IQR), × 106/L | 282.00 (145.00–350.50) | 236.00 (154.50–367.75) | − 0.422 | 0.673 |
CD8+, median (IQR), × 106/L | 145.00 (95.00–225.50) | 135.00 (90.75–185.00) | − 0.340 | 0.734 |
CD19+, median (IQR), × 106/L | 119.00 (77.50–156.50) | 102.00 (72.25–130.75) | − 1.000 | 0.317 |
NK, median (IQR), × 106/L | 86.00 (60.00–175.00) | 103.00 (82.25–124.75) | 0.284 | 0.776 |
CD3+, median (IQR),% | 61.22 (53.58–67.36) | 66.93 (55.12–69.16) | 1.229 | 0.219 |
CD4+, median (IQR),% | 37.78 (29.39–42.93) | 38.36 (27.61–46.54) | 0.440 | 0.660 |
CD8+, median (IQR),% | 20.60 (17.11–28.12) | 23.09 (17.65–29.87) | 0.706 | 0.480 |
CD19+, median (IQR),% | 17.98 (15.78–22.67) | 15.35 (11.19–20.80) | − 1.596 | 0.110 |
NK, median (IQR),% | 16.68 (9.62–26.46) | 18.95 (12.06–22.85) | 0.037 | 0.971 |
CD4+/CD8+, median (IQR) | 1.53 (1.15–2.43) | 1.55 (1.10–2.51) | − 0.303 | 0.762 |
Cytokine profiles | ||||
IL-4, median (IQR), pg/mL | 1.68 (1.31–2.47) | 1.64 (1.20–2.36) | − 0.725 | 0.468 |
IL-6, median (IQR), pg/mL | 10.12 (2.52–43.99) | 20.48 (14.27–51.22) | 1.517 | 0.129 |
IL-10, median (IQR), pg/mL | 3.76 (2.79–5.17) | 3.85 (3.09–4.90) | 0.339 | 0.734 |
IL-17, median (IQR), pg/mL | 1.15 (1.04–1.36) | 1.21 (0.96–1.43) | 0.073 | 0.941 |
TNF-α, median (IQR), pg/mL | 3.12 (1.88–5.04) | 2.97 (1.30–5.84) | − 0.028 | 0.978 |
IFN-γ, median (IQR), pg/mL | 5.18 (1.77–8.72) | 3.73 (2.61–8.73) | 0.009 | 0.993 |
Characteristic | Hospital admission | ICU admission | Z value | P value |
---|---|---|---|---|
Lymphocyte classification | ||||
Lymphocyte, median (IQR), × 106/L | 561.00 (477.00–767.00) | 498.50 (301.00–712.50) | − 1.682 | 0.093 |
CD3+, median (IQR), × 106/L | 347.00 (254.25–520.50) | 267.00 (117.50–499.25) | − 1.784 | 0.074 |
CD4+, median (IQR), × 106/L | 236.00 (152.25–369.25) | 174.00 (56.25–273.50) | − 1.784 | 0.074 |
CD8+, median (IQR), × 106/L | 125.00 (86.75–185.00) | 101.00 (51.25–190.75) | − 1.580 | 0.114 |
CD19+, median (IQR), × 106/L | 108.50 (85.75–136.00) | 98.50 (58.50–122.50) | − 1.887 | 0.059 |
NK, median (IQR), × 106/L | 99.50 (77.25–124.25) | 97.00 (57.75–125.25) | − 0.866 | 0.386 |
CD3+, median (IQR),% | 67.31 (54.31–69.75) | 54.72 (40.50–70.09) | − 2.191 | 0.028 |
CD4+, median (IQR),% | 40.69 (26.76–49.50) | 33.60 (22.43–39.50) | − 2.293 | 0.022 |
CD8+, median (IQR),% | 21.88 (17.25–26.61) | 19.91 (14.78–26.61) | − 1.479 | 0.139 |
CD19+, median (IQR),% | 16.82 (12.84–23.31) | 19.32 (11.66–26.93) | − 1.478 | 0.139 |
NK, median (IQR),% | 16.25 (8.95–24.06) | 19.40 (10.79–29.06) | 2.293 | 0.022 |
CD4+/CD8+, median (IQR) | 1.90 (1.14–2.67) | 1.74 (1.09–1.92) | − 2.191 | 0.028 |
Cytokine profiles | ||||
IL-4, median (IQR), pg/mL | 1.42 (1.23–2.21) | 1.81 (1.34–2.43) | 1.992 | 0.046 |
IL-6, median (IQR), pg/mL | 19.01 (13.26–57.87) | 16.87 (4.13–69.75) | − 0.314 | 0.753 |
IL-10, median (IQR), pg/mL | 3.69 (3.12–4.81) | 3.63 (2.75–6.00) | − 0.734 | 0.463 |
IL-17, median (IQR), pg/mL | 1.17 (0.95–1.39) | 1.24 (1.03–1.53) | 1.572 | 0.116 |
TNF-α, median (IQR), pg/mL | 2.89 (1.22–5.93) | 3.75 (2.66–5.66) | 0.943 | 0.345 |
IFN-γ, median (IQR), pg/mL | 3.37 (2.08–11.80) | 4.12 (2.08–10.70) | 0.943 | 0.345 |