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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

10.02.2022 | COVID-19 | Review Zur Zeit gratis

Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review

verfasst von: Nhu Ngoc Nguyen, Van Thuan Hoang, Thi Loi Dao, Pierre Dudouet, Carole Eldin, Philippe Gautret

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2022

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Abstract

Background

Long COVID-19 may affect patients after hospital discharge.

Aims

This study aims to describe the burden of the long-term persistence of clinical symptoms in COVID-19 patients.

Methods

We conducted a systematic review by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. The PubMed and Google Scholar databases were searched for studies that included information on the prevalence of somatic clinical symptoms lasting at least 4 weeks after the onset of a PCR- or serology-confirmed diagnosis of COVID-19. The prevalence of persisting clinical symptoms was assessed and risk factors were described when investigated. Psychological symptoms and cognitive disorders were not evaluated in this study.

Results

Thirty-seven articles met the inclusion criteria. Eighteen studies involved in-patients only with a duration of follow-up of either less than 12 weeks, 12 weeks to 6 months, or more. In these studies, fatigue (16–64%), dyspnea (15–61%), cough (2–59%), arthralgia (8–55%), and thoracic pain (5–62%) were the most frequent persisting symptoms. In nineteen studies conducted in a majority of out-patients, the persistence of these symptoms was lower and 3% to 74% of patients reported prolonged smell and taste disorders. The main risk factors for persisting symptoms were being female, older, having comorbidities and severity at the acute phase of the disease.

Conclusion

COVID-19 patients should have access to dedicated multidisciplinary healthcare allowing a holistic approach. Effective outpatient care for patients with long-COVID-19 requires coordination across multiple sub-specialties, which can be proposed in specialized post-COVID units.

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Titel: Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review
verfasst von: Nhu Ngoc Nguyen
Van Thuan Hoang
Thi Loi Dao
Pierre Dudouet
Carole Eldin
Philippe Gautret
Publikationsdatum: 10.02.2022
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-022-04417-4

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Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review

Abstract

Background

Aims

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Results

Conclusion

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