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Erschienen in: Updates in Surgery 2/2020

04.06.2020 | COVID-19 | Original Article Zur Zeit gratis

Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center

verfasst von: Giammauro Berardi, Marco Colasanti, Giovanni Battista Levi Sandri, Celeste Del Basso, Stefano Ferretti, Andrea Laurenzi, Nicola Guglielmo, Roberto Luca Meniconi, Mario Antonini, Gianpiero D’Offizi, Giuseppe Maria Ettorre

Erschienen in: Updates in Surgery | Ausgabe 2/2020

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Abstract

COVID-19 is rapidly spreading worldwide. Healthcare systems are struggling to properly allocate resources while ensuring cure for diseases outside of the infection. The aim of this study was to demonstrate how surgical activity was affected by the virus outbreak and show the changes in practice in a tertiary referral COVID-19 center. The official bulletins of the Italian National Institute for the Infectious Diseases “L. Spallanzani” were reviewed to retrieve the number of daily COVID-19 patients. Records of consecutive oncological and transplant procedures performed during the outbreak were reviewed. Patients with a high probability of postoperative intensive care unit (ICU) admission were considered as high risk and defined by an ASA score ≥ III and/or a Charlson Comorbidity Index (CCI) ≥ 6 and/or a Revised Cardiac Risk Index for Preoperative Risk (RCRI) ≥ 3. 72 patients were operated, including 12 (16.6%) liver and kidney transplantations. Patients had few comorbidities (26.3%), low ASA score (1.9 ± 0.5), CCI (3.7 ± 1.3), and RCRI (1.2 ± 0.6) and had overall a low risk of postoperative ICU admission. Few patients had liver cirrhosis (12.5%) or received preoperative systemic therapy (16.6%). 36 (50%) high-risk surgical procedures were performed, including major hepatectomies, pancreaticoduodenectomies, total gastrectomies, multivisceral resections, and transplantations. Despite this, only 15 patients (20.8%) were admitted to the ICU. Only oncologic cases and transplantations were performed during the COVID-19 outbreak. Careful selection of patients allowed to perform major cancer surgeries and transplantations without further stressing hospital resources, meanwhile minimizing collateral damage to patients.
Literatur
1.
Zurück zum Zitat Wynants L, Van Calster B, Bonten MMJ, Collins GS, Debray TPA, De Vos M, Haller MC, Heinze G, Moons KGM, Riley RD, Schuit E, Smits LJM, Snell KIE, Steyerberg EW, Wallisch C, van Smeden M (2020) Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ 369:m1328CrossRef Wynants L, Van Calster B, Bonten MMJ, Collins GS, Debray TPA, De Vos M, Haller MC, Heinze G, Moons KGM, Riley RD, Schuit E, Smits LJM, Snell KIE, Steyerberg EW, Wallisch C, van Smeden M (2020) Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ 369:m1328CrossRef
2.
Zurück zum Zitat Liang W, Guan W, Chen R, Wang W, Li J, Xu K, Li C, Ai Q, Lu W, Liang H, Li S, He J (2020) Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 21(3):335–337CrossRef Liang W, Guan W, Chen R, Wang W, Li J, Xu K, Li C, Ai Q, Lu W, Liang H, Li S, He J (2020) Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 21(3):335–337CrossRef
3.
Zurück zum Zitat Wu Z, McGoogan JM (2020) Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 323:1239–1242CrossRef Wu Z, McGoogan JM (2020) Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 323:1239–1242CrossRef
4.
Zurück zum Zitat Dong E, Du H, Gardner L (2020) An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis 20:533–534CrossRef Dong E, Du H, Gardner L (2020) An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis 20:533–534CrossRef
6.
Zurück zum Zitat Remuzzi A, Remuzzi G (2020) COVID-19 and Italy: what next? Lancet 395:1225–1228CrossRef Remuzzi A, Remuzzi G (2020) COVID-19 and Italy: what next? Lancet 395:1225–1228CrossRef
8.
Zurück zum Zitat Guerci C, Maffioli A, Bondurri AA, Ferrario L, Lazzarin F, Danelli P (2020) COVID-19: How can a department of general surgery survive in a pandemic? Surgery 167:909–911CrossRef Guerci C, Maffioli A, Bondurri AA, Ferrario L, Lazzarin F, Danelli P (2020) COVID-19: How can a department of general surgery survive in a pandemic? Surgery 167:909–911CrossRef
10.
Zurück zum Zitat Danese S, Cecconi M, Spinelli A (2020) Management of IBD during the COVID-19 outbreak: resetting clinical priorities. Nat Rev Gastroenterol Hepatol 17:253–255CrossRef Danese S, Cecconi M, Spinelli A (2020) Management of IBD during the COVID-19 outbreak: resetting clinical priorities. Nat Rev Gastroenterol Hepatol 17:253–255CrossRef
13.
Zurück zum Zitat Ramirez PT, Chiva L, Eriksson AGZ, Frumovitz M, Fagotti A, Gonzalez Martin A, Jhingran A, Pareja R (2020) COVID-19 global pandemic: options for management of gynecologic cancers. Int J Gynecol Cancer 30(5):561–563CrossRef Ramirez PT, Chiva L, Eriksson AGZ, Frumovitz M, Fagotti A, Gonzalez Martin A, Jhingran A, Pareja R (2020) COVID-19 global pandemic: options for management of gynecologic cancers. Int J Gynecol Cancer 30(5):561–563CrossRef
14.
Zurück zum Zitat Iacobucci G (2020) Covid-19: all non-urgent elective surgery is suspended for at least three months in England. BMJ 368:m1106CrossRef Iacobucci G (2020) Covid-19: all non-urgent elective surgery is suspended for at least three months in England. BMJ 368:m1106CrossRef
15.
Zurück zum Zitat Lambertini M, Toss A, Passaro A, Criscitiello C, Cremolini C, Cardone C, Loupakis F, Viscardi G, Meattini I, Dieci MV, Ferrara R, Giusti R, Maio MD (2020) Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective. ESMO Open 5(2):e000759CrossRef Lambertini M, Toss A, Passaro A, Criscitiello C, Cremolini C, Cardone C, Loupakis F, Viscardi G, Meattini I, Dieci MV, Ferrara R, Giusti R, Maio MD (2020) Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective. ESMO Open 5(2):e000759CrossRef
16.
Zurück zum Zitat Nicastri E, Petrosillo N, Bartoli TA, Lepore L, Mondi A, Palmieri F, D'Offizi G, Marchioni L, Murachelli S, Ippolito G, Antinori A (2020) National Institute for the Infectious Diseases "L. Spallanzani", IRCCS. Recommendations for COVID-19 clinical management. Infect Dis Rep 12(1):8543CrossRef Nicastri E, Petrosillo N, Bartoli TA, Lepore L, Mondi A, Palmieri F, D'Offizi G, Marchioni L, Murachelli S, Ippolito G, Antinori A (2020) National Institute for the Infectious Diseases "L. Spallanzani", IRCCS. Recommendations for COVID-19 clinical management. Infect Dis Rep 12(1):8543CrossRef
17.
Zurück zum Zitat Nicastri E, Castilletti C, Biava M, Fusco FM, Petrosillo N, Puro V, Lauria FN, Capobianchi MR, Di Caro A, Ippolito G (2017) Enabling rapid response to the 2014–2016 ebola epidemic: the experience and the results of the National Institute for Infectious Diseases Lazzaro Spallanzani. Adv Exp Med Biol 972:103–122CrossRef Nicastri E, Castilletti C, Biava M, Fusco FM, Petrosillo N, Puro V, Lauria FN, Capobianchi MR, Di Caro A, Ippolito G (2017) Enabling rapid response to the 2014–2016 ebola epidemic: the experience and the results of the National Institute for Infectious Diseases Lazzaro Spallanzani. Adv Exp Med Biol 972:103–122CrossRef
18.
Zurück zum Zitat Nicastri E, Petrosillo N, Macri G, Ippolito G (2003) Severe acute respiratory syndrome: the first transmissible disease of the 21st century. Recenti Prog Med 94(7–8):295–303PubMed Nicastri E, Petrosillo N, Macri G, Ippolito G (2003) Severe acute respiratory syndrome: the first transmissible disease of the 21st century. Recenti Prog Med 94(7–8):295–303PubMed
19.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383CrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383CrossRef
20.
Zurück zum Zitat Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B, Burke DS, O'Malley TA, Goroll AH, Caplan CH, Nolan J, Carabello B, Slater EE (1977) Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med 297(16):845–850CrossRef Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B, Burke DS, O'Malley TA, Goroll AH, Caplan CH, Nolan J, Carabello B, Slater EE (1977) Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med 297(16):845–850CrossRef
21.
Zurück zum Zitat Mayhew D, Mendonca V, Murthy BVS (2019) A review of ASA physical status - historical perspectives and modern developments. Anaesthesia 74(3):373–379CrossRef Mayhew D, Mendonca V, Murthy BVS (2019) A review of ASA physical status - historical perspectives and modern developments. Anaesthesia 74(3):373–379CrossRef
22.
Zurück zum Zitat Strasberg SM (2005) Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg 12(5):351–355CrossRef Strasberg SM (2005) Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg 12(5):351–355CrossRef
23.
Zurück zum Zitat Kiran T, Saket G (2020) Are we harming cancer patients by delaying their cancer surgery during the COVID-19 pandemic? Ann Surg (In press) Kiran T, Saket G (2020) Are we harming cancer patients by delaying their cancer surgery during the COVID-19 pandemic? Ann Surg (In press)
24.
Zurück zum Zitat Bartlett DL, Howe JR, Chang G, Crago A, Hogg M, Karakousis G, Levine E, Maker A, Mamounas E, McGuire K, Merchant N, Shibata D, Sohn V, Solorzano C, Turaga K, White R, Yang A, Yoon S, Society of Surgical O (2020) Management of cancer surgery cases during the COVID-19 pandemic: considerations. Ann Surg Oncol 27:1717–1720CrossRef Bartlett DL, Howe JR, Chang G, Crago A, Hogg M, Karakousis G, Levine E, Maker A, Mamounas E, McGuire K, Merchant N, Shibata D, Sohn V, Solorzano C, Turaga K, White R, Yang A, Yoon S, Society of Surgical O (2020) Management of cancer surgery cases during the COVID-19 pandemic: considerations. Ann Surg Oncol 27:1717–1720CrossRef
25.
Zurück zum Zitat Desai A, Sachdeva S, Parekh T, Desai R (2020) COVID-19 and cancer: lessons from a pooled meta-analysis. JCO Glob Oncol 6:557–559CrossRef Desai A, Sachdeva S, Parekh T, Desai R (2020) COVID-19 and cancer: lessons from a pooled meta-analysis. JCO Glob Oncol 6:557–559CrossRef
32.
Zurück zum Zitat Agnes S, Andorno E, Avolio AW, Baccarani U, Carraro A, Cescon M, Cillo U, Colledan M, De Carlis L, De Simone P, De Ville De Goyet J, Di Benedetto F, Ettorre GM, Gringeri E, Gruttadauria S, Lupo LG, Mazzaferro V, Regalia E, Romagnoli R, Rossi GE, Rossi M, Spada M, Tisone G, Vennarecci G, Vivarelli M, Zamboni F, Boggi U (2020) Preliminary analysis of the impact of COVID-19 outbreak on Italian liver transplant programs. Liver Transpl. https://doi.org/10.1002/lt.25790 CrossRefPubMedCentral Agnes S, Andorno E, Avolio AW, Baccarani U, Carraro A, Cescon M, Cillo U, Colledan M, De Carlis L, De Simone P, De Ville De Goyet J, Di Benedetto F, Ettorre GM, Gringeri E, Gruttadauria S, Lupo LG, Mazzaferro V, Regalia E, Romagnoli R, Rossi GE, Rossi M, Spada M, Tisone G, Vennarecci G, Vivarelli M, Zamboni F, Boggi U (2020) Preliminary analysis of the impact of COVID-19 outbreak on Italian liver transplant programs. Liver Transpl. https://​doi.​org/​10.​1002/​lt.​25790 CrossRefPubMedCentral
36.
Zurück zum Zitat Li CI, Pai JY, Chen CH (2020) Characterization of smoke generated during the use of surgical knife in laparotomy surgeries. J Air Waste Manag Assoc 70(3):324–332CrossRef Li CI, Pai JY, Chen CH (2020) Characterization of smoke generated during the use of surgical knife in laparotomy surgeries. J Air Waste Manag Assoc 70(3):324–332CrossRef
37.
Zurück zum Zitat Spinelli A, Pellino G (2020) COVID-19 pandemic: perspectives on an unfolding crisis. Br J Surg 107(7):785–787CrossRef Spinelli A, Pellino G (2020) COVID-19 pandemic: perspectives on an unfolding crisis. Br J Surg 107(7):785–787CrossRef
38.
Zurück zum Zitat Rohan P, O'Reilly MK, Gibney B, Nason GJ (2020) Supply of personal protective equipment (PPE) during the Covid-19 pandemic. Ir Med J 113(4):66PubMed Rohan P, O'Reilly MK, Gibney B, Nason GJ (2020) Supply of personal protective equipment (PPE) during the Covid-19 pandemic. Ir Med J 113(4):66PubMed
40.
Zurück zum Zitat Kurihara H, Bisagni P, Faccincani R, Zago M (2020) COVID-19 outbreak in Northern Italy: viewpoint of the Milan area surgical community. J Trauma Acute Care Surg 88(6):719–724CrossRef Kurihara H, Bisagni P, Faccincani R, Zago M (2020) COVID-19 outbreak in Northern Italy: viewpoint of the Milan area surgical community. J Trauma Acute Care Surg 88(6):719–724CrossRef
41.
Zurück zum Zitat McBride KE, Brown K, Fisher OM, Steffens D, Yeo D, Koh CE (2020) Impact of the COVID-19 pandemic on surgical services: early experiences at a nominated COVID-19 centre. ANZ J Surg 90(5):663–665CrossRef McBride KE, Brown K, Fisher OM, Steffens D, Yeo D, Koh CE (2020) Impact of the COVID-19 pandemic on surgical services: early experiences at a nominated COVID-19 centre. ANZ J Surg 90(5):663–665CrossRef
42.
Zurück zum Zitat Peloso A, Moeckli B, Oldani G, Triponez F, Toso C (2020) Response of a European surgical department to the COVID-19 crisis. Swiss Med Wkly 150:w20241PubMed Peloso A, Moeckli B, Oldani G, Triponez F, Toso C (2020) Response of a European surgical department to the COVID-19 crisis. Swiss Med Wkly 150:w20241PubMed
Metadaten
Titel
Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center
verfasst von
Giammauro Berardi
Marco Colasanti
Giovanni Battista Levi Sandri
Celeste Del Basso
Stefano Ferretti
Andrea Laurenzi
Nicola Guglielmo
Roberto Luca Meniconi
Mario Antonini
Gianpiero D’Offizi
Giuseppe Maria Ettorre
Publikationsdatum
04.06.2020
Verlag
Springer International Publishing
Schlagwort
COVID-19
Erschienen in
Updates in Surgery / Ausgabe 2/2020
Print ISSN: 2038-131X
Elektronische ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-020-00825-3

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