Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Annals of Hematology
Erschienen in: Annals of Hematology 8/2020

24.06.2020 | COVID-19 | Review Article Zur Zeit gratis

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

verfasst von: Monia Marchetti

Erschienen in: Annals of Hematology | Ausgabe 8/2020

Einloggen, um Zugang zu erhalten

Abstract

COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.
Literatur
1.
Siordia JA (2020) Epidemiology and clinical features of COVID-19: a review of current literature. J Clin Virol 127:104357PubMedPubMedCentral
2.
Giannis D, Ziogas IA, Gianni P (2020) Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERSD-CoV and lessons from the past. J Virol 127:104362
3.
Esher R, Breakey N, Lammle B (2020) Severe COVID-19 infection associated with endothelial activation. Thromb Res 190:62
4.
5.
Russkamp NF, Ruemmler R, Roewe J, Moore BB, Ward PA, Bosmann M (2015) Experimental design of complement component C5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB J 29:3762–3772
6.
Barrett CD, Hsu AT, Ellson CD et al (2018) Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Clin Exp Immunol 194:103–117PubMedPubMedCentral
7.
Ward PA, Fattahi F, Bosmann M (2016) New insights into molecular mechanisms of immune complex-induced injury in lung. Front Immunol 7:86PubMedPubMedCentral
8.
Fattahi F, Kalbitz M, Malan EA, Abe E, Jajou L, Huber-Lang MS, Bosmann M, Russell MW, Zetoune FS, Ward PA (2017) Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J 31:4129–4139PubMedPubMedCentral
9.
Donnelly TJ, Meade P, Jagels M et al (1994) Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. Crit Care Med 22:768–776PubMed
10.
Ip WKE, Chan KH, Law HKW, Tso GHW, Kong EKP, Wong WHS, To YF, Yung RWH, Chow EY, Au KL, Chan EYT, Lim W, Jensenius JC, Turner MW, Peiris JSM, Lau YL (2005) Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. J Infect Dis 191:1697–1704PubMedPubMedCentral
11.
Wang J, Sahoo M, Lantier L, Warawa J, Cordero H, Deobald K, Re F (2018) Caspase-1-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18. PLoS Pathog 14:e1007105PubMedPubMedCentral
12.
Wang YC, Liu QX, Liu T, Xu XE, Gao W, Bai XJ, Li ZF (2018) Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients: a prospective observational study. Medicine (Baltimore) 97:e9859
13.
Khan MA, Shamma T, Kazmi S, Altuhami A, Ahmed HA, Assiri AM, Broering DC (2020) Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants. J Transl Med 18:147PubMedPubMedCentral
14.
Lin YC, Liao YJ, Lee YH (2019) Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitization. Cell Microbiol 21:e13085PubMed
15.
Fattahi F, Frydrych LM, Bian G (2018) Role of complement C5a and histones in septic cardiomyopathy. Mol Immunol 102:32–41PubMedPubMedCentral
16.
Orrrem HL, Nilsson PH, Piscke SE (2018) IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Front Immunol 9:2035
17.
Wang W, Cai D (2020) Complement components sC5b-9 and CH50 predict prognosis in heart failure patients combined with hypertension. Am J Hypertens 33:53–60
18.
Chen X-H, Ruan C-C, Ge Q, Ma Y, Xu JZ, Zhang ZB, Lin JR, Chen DR, Zhu DL, Gao PJ (2018) Deficiency of complement C3 and C5 receptors prevents angiotensin II-induced hypertension via regulatory T cells. Circ Res 122:970–983PubMed
19.
Ng WF, To KF, Lam WWL et al (2006) The comparative pathology of severe acute respiratory syndrome and avian influenza a subtype H5N1-a review. Hum Pathol 37:381–390PubMedPubMedCentral
20.
Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y (2011) Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza. Microbiol Immunol 55:191–198PubMed
21.
Wang R, Xiao H, Guo R, Li Y, Shen B (2015) The role of C5a in acute lung injury induced by highly pathogenic viral infections. Emerg Microbes Infect 4:e28PubMedPubMedCentral
22.
23.
24.
25.
Pang RTK, Poon TCW, Chan KCA, Lee NLS, Chiu RWK, Tong YK, Wong RMY, Chim SSC, Ngai SM, Sung JJY, Lo YMD (2006) Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome. Clin Chem 52:421–429PubMedPubMedCentral
26.
Sun S, Zhao G, Liu C, Wu X, Guo Y, Yu H, Song H, du L, Jiang S, Guo R, Tomlinson S, Zhou Y (2013) Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. Am J Respir Cell Mol Biol 49:221–230PubMed
27.
Socié G, Caby-Tosi MP, Marantz JL, Cole A, Bedrosian CL, Gasteyger C, Mujeebuddin A, Hillmen P, Vande Walle J, Haller H (2019) Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical uraemic syndrome: 10-year pharmacovigilance analysis. Br J Haemtol 185:297–310
28.
Condom P, Mansury JM, Decramer S et al (2017) Atypical hemolytic uremic syndrome triggered by varicella infection. IDCases 9:89–90PubMedPubMedCentral
29.
Fraga-Rodriguez GM, Brio’-Sanguistin S, Turon-Vinas E, et al. (2017) Eculizumab in a child with atypical haemolytic uraemic syndrome and haemophagocytic lymphohistiocytosis triggered by cytomegalovirus infection. BMJ Case Rep
30.
Méndez R, Menéndez R, Amara-Elori I et al (2019) Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Inf Secur 78:423–431
31.
Romacho T, Valencia I, Ramos-Gonzales M et al (2020) Visfatin/eNampt induces endothelial dysfunction in vivo: a role for toll-like receptor 4 and NLRP3 inflammasome. Sci Rep 10:5386PubMedPubMedCentral
32.
Dolmatova EV, Wang K, Mandavilli R, et al. (2020) The effects of sepsis on endothelium and clinical implications. Cardiovasc Res (in press)
33.
Levi M, van der Poll T (2017) Coagulation and sepsis. Thromb Res 149:38–44PubMed
34.
Schmitt FCF, Manolov V, Morgenstern J, Fleming T, Heitmeier S, Uhle F, al-Saeedi M, Hackert T, Bruckner T, Schöchl H, Weigand MA, Hofer S, Brenner T (2019) Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study. Ann Intensive Care 9:19PubMedPubMedCentral
35.
Shrivastava G, Visoso-Carvajal G, Carcia-Cordero J et al (2020) Dengue virus serotype 2 and its non-structural proteins 2A and 2B activate TLRP3 inflammasome. Front Immunol 11:352PubMedPubMedCentral
36.
Babu FS, LaPorte HM, Nassoiy SP, Majetschak M (2019) Chemokine (C-X-C motif) receptor 4 regulates lung endothelial barrier permeability during resuscitation from hemorrhagic shock. Physiol Res 68:675–679PubMedPubMedCentral
37.
Gupta N, Zhao YY, Evans CE (2019) The stimulation of thrombosis by hypoxia. Thromb Res 181:77–83PubMed
38.
Ye J, Zhang B, Xu J, Chang Q, McNutt MA, Korteweg C, Gong E, Gu J (2007) Molecular pathology in the lungs of severe acute respiratory syndrome patients. Am J Pathol 170:538–545PubMedPubMedCentral
39.
Tang N, Li D, Wang X, Sun Z (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18(4):844–847PubMedPubMedCentral
40.
Chan JCK, Tsui ELH, Wong VCW et al (2007) Prognostication in severe acute respiratory syndrome: a retrospective time-course analysis of 1312 laboratory-confirmed patients in Hong Kong. Respirology 12:531–542PubMedPubMedCentral
41.
Zhou P, Ma B, Xu S, Zhang S, Tang H, Zhu S, Xiao S, Ben D, Xia Z (2014) Knockdown of Bruton’s kinase tyrosine kinase confers potent protection against sepsis-induced acute lung injury. Cell Biochem Biophys 70:1265–1275PubMed
42.
Xu L, Geng T, Zang G, Bo L, Liang Y, Zhou H, Yan J (2020) Exosome derived from CD137-modified endothelial cells regulates the Th17 responses in atherosclerosis. J Cell Mol Med 24:4659–4667PubMedPubMedCentral
43.
Lu K, Zhao J, Liu W et al (2020) Macrophage stimulating 1-induced inflammation response promotes aortic aneurysm formation through triggering endothelial cells death and activating NF-kB signaling pathway. J Recept Signal Transduction 40:374–382
44.
Li X, Fang P, Sun Y et al (2020) Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells. Redox Biol 28:101273
45.
Agarwal S, Sharma H, Chen L, Dhillon NK (2020) NADPH oxidase mediated endothelial injury in HIV and opioid induced pulmonary arterial hypertension. Am J Phys Lung Cell Mol Phys 318:L1097–L1108
46.
He H, Xiao S, Xu G et al (2020) the NADPH oxidase 4 protects vascular endothelial cells from copper oxide nanoparticles-induced oxidative stress and cell death. Life Sci 252:117571PubMed
47.
Cui Y, Chen G, Yang Z (2020) Mitochondrial superoxide mediates PM2.5-induced cytotoxicity in human pulmonary lymphatic endothelial cells. Environ Pollut 263:114423PubMed
48.
Connor DE, Gerbelli J, Chew AN (2020) Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro. Phlebology 268355520913384
49.
50.
Song J, Hu B, Qu H et al (2020) Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells. Biochem Biophys Res Commun 525:812–818PubMed
51.
52.
Kalkan BM, Akol S, Ak D et al (2020) Casin and ADM3100 enhance endothelial cell proliferation, tube formation and sprouting. Microvasc Res 130:104001PubMed
53.
Geven C, Bergmann A, Kox M, Pickkers P (2018) Vascular effects of adrenomedullin and the anti-adrenomedullin antibody adrecizumab in sepsis. Shock 50:132–140
54.
Lippi G, Plebani M, Henry BM (2020) Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID −19) infections: a meta-analysis. Clin Chem Acta 506:145–148
55.
56.
57.
Yin S, Huang M, Li D (2020) Difference of coagulation features between severe pneumonia induced by SARS-SoV2 and non-SARS-CoV2. J Thromb Thrombolysis
58.
Bellingan G, Jacono F, Bannard SJ et al (2019) Primary analysis of a phase 1/2 study to assess MultiStem® cell therapy, a regenerative advanced medicinal product (ATMP) in acute respiratory distress syndrome (MUST-ARDS). Am J Respir Crit Care Med 199:A7353
59.
Iba T, Hashiguci N, Nagaoka I et al (2015) Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction. Intensive Care Med Exp 31:36
60.
Liu Y, Mu S, Li X, Liang Y, Wang L, Ma X (2019) Unfractionated heparin alleviates sepsis-induced acute lung injury by protecting tight junctions. J Surg Res 238:175–185PubMed
61.
Potterucha TJ, Libby P, Goldhaber SZ (2017) More than an anticoagulant: do heparins have direct anti-inflammatory effects? Thromb Haemost 28(117):437–444
62.
SeuNg H, Wadle C, Hopp T, et al. (2018) P2Y12 is involved in emergency hematopoiesis after myocardial infarction. Eur Heart J 39 suppl 1: 694
63.
Bartoszewski R, Moszyńska A, Serocki M, Cabaj A, Polten A, Ochocka R, Dell'Italia L, Bartoszewska S, Króliczewski J, Dąbrowski M, Collawn JF (2019) Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia. FASEB J 33:7929–7941PubMedPubMedCentral
64.
Gong H, Rehman J, Tang H, Wary K, Mittal M, Chatturvedi P, Zhao Y, Komorova YA, Vogel SM, Malik AB (2015) HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest 125:652–664PubMedPubMedCentral
65.
Suresh MV, Malijepalli S, Zhang B (2019) Hypoxia-inducible factor (HIF)-1alpha promotes inflammation and injury following aspiration-induced lung injury in mice. Shock 52:612–621PubMed
66.
Kimura Y, Inoue K, Abe M, Nearman J, Baranowska-Kortylewicz J (2007) PDGFRβ and HIF-1α inhibition with imatinib and radioimmunotherapy of experimental prostate cancer. Cancer Biol Ther 6:1763–1772PubMed
67.
Veith C, Zakrzewicz D, Dahal BK (2014) Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorilation in pulmonary hypertension is reversed by HIF-1alpha depletion or imatinib treatment. Thromb Haemost 112:1288–1303PubMed
68.
Takei Y, Yamada M, Saito K et al (2019) Increase in circulating ACE-positive endothelial microparticles during acute lung injury. Eur Respir J 54:4
69.
Moussa MD, Santonocito C, Fagnoul D et al (2014) Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells. Intensive Care Med 2:231–238
70.
Rafat N, Nanusch C, Brikkoetter PT et al (2007) Increased circulating endothelial progenitor cells in septic patients: correlation with survival. Crit Care Med 7:1677–1684
71.
Qi Y, Qian L, Sun B et al (2017) Inhaled NO contributes to lung repair in piglets with acute respiratory distress syndrome via increasing circulating endothelial progenitor cells. PLoS One 3:e33859
72.
Gao X, Chen W, Liang Z, Chen L (2011) Autotransplantation of circulating endothelial progenitor cells protects against lipopolysaccharide-induced acute lung injury in rabbit. Int Immunopharmacol 11:1584–1590PubMed
73.
Liu X, Tan W, Liu Y, Lin G, Xie C (2013) The role of the beta2 adrenergic receptor on endothelial progenitor cells dysfunction of proliferation and migration in chronic obstructive pulmonary disease patients. Expert Opin Ther Targets 17:485–500PubMed
74.
Hallgren R, Samuelsson T, Laurent TC et al (1989) Accumulation of hyaluronan (hyaluronic acid) in the lung in adult respiratory distress syndrome. Am Rev Respir Dis 139:682–687PubMed
75.
Bell TJ, Borgan DJ, Salek-Ardakani S et al (2018) Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis. Matrix Biol 80:14–28PubMed
76.
Collum SD, Chen NY, Hernandez AM et al (2017) Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis. Br J Pharmacol 174:284–301
77.
Letsiou E, Rizzo AN, Sammani S, Naureckas P, Jacobson JR, Garcia JGN, Dudek SM (2015) Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury. Am J Phys Lung Cell Mol Phys 308:L259–L269
78.
Aman J, van Bezu J, Damanafshan A, Huveneers S, Eringa EC, Vogel SM, Groeneveld ABJ, Vonk Noordegraaf A, van Hinsbergh VWM, van Nieuw Amerongen GP (2012) Effective treatment of edema and endothelial barrier dysfunction with imatinib. Circulation 126:2728–2738
79.
An R, Ammani S, Esquinca AE et al (2015) Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury. Am J Phys Lung Cell Mol Phys 309:L1294–L1304
80.
Koning NJ, de Lange F, van Meurs M, Jongman RM, Ahmed Y, Schwarte LA, van Nieuw Amerongen GP, Vonk ABA, Niessen HW, Baufreton C, Boer C (2018) Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass. Br J Anaesth 120:1165–1175PubMed
81.
Sato H, Sugimura K, Miura M, Konno R, Kozu K, Yaoita N, Shimizu T, Yamamoto S, Aoki T, Tatebe S, Satoh K, Shimokawa H (2019) Beneficial effects of imatinib in a patient with suspected pulmonary veno-occlusive disease. Tohoku J Exp Med 247:69–73PubMed
82.
Overbeek MJ, van Nieuw Amerongen GP, Boonstra A, Smit EF, Vonk-Noordegraaf A (2008) Possible role of imatinib in clinical pulmonary veno-occlusive disease. Eur Respir J 32:232–235PubMed
83.
Feniocchio E, Depetris I, Campanella D et al (2016) Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report. BMC Cancer 16:793
84.
Carnevale-Schianca F (2010) S. Gallo, D. Rota-Scalabrini, D. Complete resolution of life-threatening bleomycin-induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin’s lymphoma: hope for severe chemotherapy-induced toxicity? J Clin Oncol 29:e691–e693
85.
Napier RJ, Norris RA, Swimm A (2015) Low dose of imatinib induce myelopoiesis and enhance host anti-microbial immunity. PLoS Pathog 11:e1004770PubMedPubMedCentral
86.
Giver CR, Shaw PA, Fletcher H et al (2019) IMPACT-TB: a phase II trial assessing the capacity of low dose imatinib to induce myelopoiesis and enhance host anti-microbial immunity against tuberculosis. Imatinib Mesylate per Oral As a Clinical Therapeutic for TB. Blood 134:1050
87.
Dyall J, Coleman CM, Hart BJ, Venkataraman T, Holbrook MR, Kindrachuk J, Johnson RF, Olinger GG Jr, Jahrling PB, Laidlaw M, Johansen LM, Lear-Rooney CM, Glass PJ, Hensley LE, Frieman MB (2014) Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother 58:4885–4893PubMedPubMedCentral
88.
Coleman CM, Sisk JM, Mingo RM, Nelson EA, White JM, Frieman MB (2016) Abelson kinase inhibitors are potent inhibitors of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus fusion. J Virol 90:8924–8933PubMedPubMedCentral
89.
Sisk JM, Frieman MB, Machmer CE (2018) Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors. J Gen Virol 99:619–630PubMedPubMedCentral
90.
Chan JF, Lau SK, To KK et al (2015) Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev 28:465–522PubMedPubMedCentral
Metadaten
Titel
COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
verfasst von
Monia Marchetti
Publikationsdatum
24.06.2020
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Annals of Hematology / Ausgabe 8/2020
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-020-04138-8

Weitere Artikel der Ausgabe 8/2020

Annals of Hematology 8/2020 Zur Ausgabe

Original Article

Bone turnover markers as an aid to monitor osteoporosis following allogeneic hematopoietic stem cell transplantation

Original Article

Safety of bedside lumbar puncture in adult patients with thrombocytopenia

Original Article

Measuring the cellular memory B cell response after vaccination in patients after allogeneic stem cell transplantation

Original Article

Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma

Original Article

Necrotizing fasciitis in haematological patients: a different scenario

Original Article

Pre-transplant FLT3/ITD status predicts outcome in FLT3-mutated acute myeloid leukemia following allogeneic stem cell transplantation

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Parodontalbehandlung verbessert Prognose bei Katheterablation

18.04.2024 | Arterielle Hypertonie | Nachrichten

Antihypertensiva schützen auch alte Menschen noch vor Demenz

18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

17.04.2024 | DGIM 2024 | Nachrichten

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie
weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise