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Erschienen in: Endocrine 2/2022

30.07.2022 | COVID-19 | Original Article

COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity

verfasst von: Sevilay Sezer, Ceylan Bal, Ayşe Kaya Kalem, Bircan Kayaaslan, Fatma Eser, İmran Hasanoglu, Esragül Akıncı, Rahmet Güner, Özcan Erel, Gülsen Yılmaz

Erschienen in: Endocrine | Ausgabe 2/2022

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Abstract

Purpose

This study aims to evaluate the correlations between the severity of the disease and serum steroid levels by analyzing the serum steroid levels in COVID-19 patients with different levels of disease progression and the control group.

Methods

Morning serum Aldosterone, 11-deoxycortisol, Androstenedione, 17-hydroxyprogesterone, Dihydrotestosterone (DHT), Dehydroepiandrosterone (DHEA), Corticosterone, Dehydroepiandrosterone sulfate (DHEAS), Estrone, Estradiol, Progesterone, 11-deoxycorticosterone, Cortisol, Corticosterone, Androsterone, Pregnenolone, 17-hydroxypregnenolone and 21-deoxycortisol levels were measured in 153 consecutive patients were grouped as mild, moderate, and severe based on the WHO COVID-19 disease severity classification and the control group. Steroid hormone levels were analyzed at once with a liquid chromatography-tandem mass spectrometric method (LC-MS/MS).

Results

In our study, nearly all steroids were statistically significantly higher in the patients’ group than in the control group (p < 0.001). Also, DHEA was an independent indicator of the disease severity with COVID-19

Conclusions

Our study reveals that the alteration in steroid hormone levels was correlated with disease severity. Also, steroid hormone levels should be followed up during COVID-19 disease management.
Literatur
2.
Zurück zum Zitat M. Wiegand et al. Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay. medRxiv 2022 M. Wiegand et al. Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay. medRxiv 2022
3.
Zurück zum Zitat R. Pal, COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications. Endocrine 68(2), 251–252 (2020) CrossRef R. Pal, COVID-19, hypothalamo-pituitary-adrenal axis and clinical implications. Endocrine 68(2), 251–252 (2020) CrossRef
4.
Zurück zum Zitat R. Pal, M. Banerjee, COVID-19 and the endocrine system: exploring the unexplored. J. Endocrinological Investig. 43(7), 1027–1031 (2020) CrossRef R. Pal, M. Banerjee, COVID-19 and the endocrine system: exploring the unexplored. J. Endocrinological Investig. 43(7), 1027–1031 (2020) CrossRef
5.
Zurück zum Zitat M.K.S. Leow et al. Hypocortisolism in survivors of severe acute respiratory syndrome (SARS). Clin. Endocrinol. 63(2), 197–202 (2005) CrossRef M.K.S. Leow et al. Hypocortisolism in survivors of severe acute respiratory syndrome (SARS). Clin. Endocrinol. 63(2), 197–202 (2005) CrossRef
6.
Zurück zum Zitat T. Tan et al. Association between high serum total cortisol concentrations and mortality from COVID-19. Lancet Diabetes Endocrinol. 8(8), 659–660 (2020) CrossRef T. Tan et al. Association between high serum total cortisol concentrations and mortality from COVID-19. Lancet Diabetes Endocrinol. 8(8), 659–660 (2020) CrossRef
7.
Zurück zum Zitat World Health Organisation. Corticosteroids for COVID-19. Living guidance 2 September 2020 World Health Organisation. Corticosteroids for COVID-19. Living guidance 2 September 2020
8.
Zurück zum Zitat M.Q. Almeida, B.B. Mendonca, Adrenal insufficiency and glucocorticoid use during the COVID-19 pandemic. Clinics 75, e2022 (2020) CrossRef M.Q. Almeida, B.B. Mendonca, Adrenal insufficiency and glucocorticoid use during the COVID-19 pandemic. Clinics 75, e2022 (2020) CrossRef
9.
Zurück zum Zitat A. Lipsa, J.S. Prabhu, Gender disparity in COVID-19: Role of sex steroid hormones. Asian Pac. J. tropical Med. 14(1), 5 (2021) CrossRef A. Lipsa, J.S. Prabhu, Gender disparity in COVID-19: Role of sex steroid hormones. Asian Pac. J. tropical Med. 14(1), 5 (2021) CrossRef
10.
Zurück zum Zitat S. Karashima, I. Osaka, Rapidity and precision of steroid hormone measurement. J. Clin. Med. 11(4), 956 (2022) CrossRef S. Karashima, I. Osaka, Rapidity and precision of steroid hormone measurement. J. Clin. Med. 11(4), 956 (2022) CrossRef
11.
Zurück zum Zitat L.M. Montaño et al. Could lower testosterone in older men explain higher COVID-19 morbidity and mortalities? Int. J. Mol. Sci. 23(2), 935 (2022) CrossRef L.M. Montaño et al. Could lower testosterone in older men explain higher COVID-19 morbidity and mortalities? Int. J. Mol. Sci. 23(2), 935 (2022) CrossRef
12.
Zurück zum Zitat M. Marazuela, A. Giustina, M. Puig-Domingo, Endocrine and metabolic aspects of the COVID-19 pandemic. Rev. Endocr. Metab. Disord. 21(4), 495–507 (2020) CrossRef M. Marazuela, A. Giustina, M. Puig-Domingo, Endocrine and metabolic aspects of the COVID-19 pandemic. Rev. Endocr. Metab. Disord. 21(4), 495–507 (2020) CrossRef
13.
Zurück zum Zitat J.F. Bermejo-Martin et al. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit. Care 24(1), 1–13 (2020) CrossRef J.F. Bermejo-Martin et al. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit. Care 24(1), 1–13 (2020) CrossRef
14.
Zurück zum Zitat A.M. Traish, Sex steroids and COVID-19 mortality in women. Trends Endocrinol. Metab. 32(8), 533–536 (2021) CrossRef A.M. Traish, Sex steroids and COVID-19 mortality in women. Trends Endocrinol. Metab. 32(8), 533–536 (2021) CrossRef
15.
Zurück zum Zitat G. Pinna, Sex and COVID-19: a protective role for reproductive steroids. Trends Endocrinol. Metab. 32(1), 3–6 (2021) CrossRef G. Pinna, Sex and COVID-19: a protective role for reproductive steroids. Trends Endocrinol. Metab. 32(1), 3–6 (2021) CrossRef
16.
Zurück zum Zitat I.E. van Zeggeren et al. Sex steroid hormones are associated with mortality in COVID-19 patients: Level of sex hormones in severe COVID-19. Medicine 100, 34 (2021) I.E. van Zeggeren et al. Sex steroid hormones are associated with mortality in COVID-19 patients: Level of sex hormones in severe COVID-19. Medicine 100, 34 (2021)
17.
Zurück zum Zitat C. Bryce et al. Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience. Mod. Pathol. 34(8), 1456–1467 (2021) CrossRef C. Bryce et al. Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience. Mod. Pathol. 34(8), 1456–1467 (2021) CrossRef
18.
Zurück zum Zitat A.S. Alzahrani et al. The impact of COVID-19 viral infection on the hypothalamic-pituitary-adrenal axis. Endocr. Pract. 27(2), 83–89 (2021) CrossRef A.S. Alzahrani et al. The impact of COVID-19 viral infection on the hypothalamic-pituitary-adrenal axis. Endocr. Pract. 27(2), 83–89 (2021) CrossRef
19.
Zurück zum Zitat M.F. Santana et al. Case report: adrenal pathology findings in severe COVID-19: an autopsy study. The. Am. J. tropical Med. Hyg. 103(4), 1604 (2020) CrossRef M.F. Santana et al. Case report: adrenal pathology findings in severe COVID-19: an autopsy study. The. Am. J. tropical Med. Hyg. 103(4), 1604 (2020) CrossRef
20.
Zurück zum Zitat S. Tomo et al. Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment? Endocr. Regul. 55(3), 174–181 (2021) CrossRef S. Tomo et al. Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment? Endocr. Regul. 55(3), 174–181 (2021) CrossRef
21.
Zurück zum Zitat D.A. Vassiliadi et al. Pituitary–adrenal responses and glucocorticoid receptor expression in critically Ill patients with COVID-19. Int. J. Mol. Sci. 22(21), 11473 (2021) CrossRef D.A. Vassiliadi et al. Pituitary–adrenal responses and glucocorticoid receptor expression in critically Ill patients with COVID-19. Int. J. Mol. Sci. 22(21), 11473 (2021) CrossRef
22.
Zurück zum Zitat X. Bertagna, Effects of chronic ACTH excess on human adrenal cortex. Front. Endocrinol. 8, 43 (2017) CrossRef X. Bertagna, Effects of chronic ACTH excess on human adrenal cortex. Front. Endocrinol. 8, 43 (2017) CrossRef
23.
Zurück zum Zitat M.S. Gonen et al. Assessment of neuroendocrine changes and hypothalamo-pituitary autoimmunity in patients with COVID-19. Horm. Metab. Res. 54(03), 153–161 (2022) CrossRef M.S. Gonen et al. Assessment of neuroendocrine changes and hypothalamo-pituitary autoimmunity in patients with COVID-19. Horm. Metab. Res. 54(03), 153–161 (2022) CrossRef
Metadaten
Titel
COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity
verfasst von
Sevilay Sezer
Ceylan Bal
Ayşe Kaya Kalem
Bircan Kayaaslan
Fatma Eser
İmran Hasanoglu
Esragül Akıncı
Rahmet Güner
Özcan Erel
Gülsen Yılmaz
Publikationsdatum
30.07.2022
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
Endocrine / Ausgabe 2/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-022-03140-6

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