Skip to main content
Erschienen in: Acta Neurologica Belgica 4/2020

09.06.2020 | COVID-19 | Original article Zur Zeit gratis

A complication of coronavirus disease 2019: delirium

verfasst von: Gabriele Cipriani, Sabrina Danti, Angelo Nuti, Cecilia Carlesi, Claudio Lucetti, Mario Di Fiorino

Erschienen in: Acta Neurologica Belgica | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

COVID-19 is predominantly a respiratory disease. However, some cases exhibit other features including Central Nervous System symptoms. In the older adult, COVID-19 may present with atypical symptoms, including delirium and its complications. The objective of this study is to describe the relationship between the new type of coronavirus infection and delirium. Systematic research (Cochrane Library and PubMed) was carried out (only upper time limit: April 2020). Publications found through this indexed search were reviewed and manually screened to identify relevant studies. Search terms used included “COVID-19, Delirium, Dementia, Intensive Care Unit”. We manually added articles identified through other sources (i.e., key journals). Older people are at the greatest risk from COVID-19. If infected, they may present delirium. Moreover, it is not exclusive to older people. Delirium is not inevitable; rather, it is preventable. Delirium prevention programs are even more crucial in the era of COVID-19 and cannot be allowed to wither despite the challenges of integrating delirium prevention with COVID-19 care. An acute change in condition, behaviour, or mental status should prompt a delirium screen. As regards the treatment, it is advisable to use non-pharmacological interventions first where possible. Medication may be needed for patients with agitation where there is intractable distress or high risk to self/others.
Literatur
2.
Zurück zum Zitat Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (2020) The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5(4):536–544CrossRef Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (2020) The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5(4):536–544CrossRef
5.
Zurück zum Zitat Chan JF, Yuan S, Kok KH et al (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 395(10223):514CrossRefPubMedPubMedCentral Chan JF, Yuan S, Kok KH et al (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 395(10223):514CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383(9920):911–922CrossRefPubMed Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383(9920):911–922CrossRefPubMed
10.
Zurück zum Zitat Devlin JW, Skrobik Y, Gelinas C et al (2018) Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 46(9):e825–e873CrossRefPubMed Devlin JW, Skrobik Y, Gelinas C et al (2018) Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 46(9):e825–e873CrossRefPubMed
11.
Zurück zum Zitat Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS (2004) Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291(14):1753–1762CrossRefPubMed Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS (2004) Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291(14):1753–1762CrossRefPubMed
12.
Zurück zum Zitat American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington, VA, USACrossRef American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington, VA, USACrossRef
13.
Zurück zum Zitat Tieges Z, Evans JJ, Neufeld KJ, MacLullich AM (2018) The neuropsychology of delirium: advancing the science of delirium assessment. Int J Geriatr Psychiatry 33(11):1501–1511CrossRefPubMed Tieges Z, Evans JJ, Neufeld KJ, MacLullich AM (2018) The neuropsychology of delirium: advancing the science of delirium assessment. Int J Geriatr Psychiatry 33(11):1501–1511CrossRefPubMed
14.
Zurück zum Zitat World Health Organization (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva World Health Organization (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva
17.
Zurück zum Zitat Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E, Ba C (2015) Partial and no recovery from delirium in older hospitalized adults: frequency and baseline risk factors. J Am Geriatr Soc 63(11):2340–2348CrossRefPubMed Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E, Ba C (2015) Partial and no recovery from delirium in older hospitalized adults: frequency and baseline risk factors. J Am Geriatr Soc 63(11):2340–2348CrossRefPubMed
22.
Zurück zum Zitat McNeil JB, Hughes CG, Girard T, EW LB, Chandrasekhar R, Han JH (2029) Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients. PLoS ONE 14(12):e0226412CrossRef McNeil JB, Hughes CG, Girard T, EW LB, Chandrasekhar R, Han JH (2029) Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients. PLoS ONE 14(12):e0226412CrossRef
25.
26.
Zurück zum Zitat Burns A, Gallagley A, Byrne J (2004) Delirium. J Neurol Neurosurg Psychiatr 75(3):362–367CrossRef Burns A, Gallagley A, Byrne J (2004) Delirium. J Neurol Neurosurg Psychiatr 75(3):362–367CrossRef
30.
31.
Zurück zum Zitat Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, Talbot PG (2019) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12(1):14CrossRefPubMedCentral Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, Talbot PG (2019) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12(1):14CrossRefPubMedCentral
32.
Metadaten
Titel
A complication of coronavirus disease 2019: delirium
verfasst von
Gabriele Cipriani
Sabrina Danti
Angelo Nuti
Cecilia Carlesi
Claudio Lucetti
Mario Di Fiorino
Publikationsdatum
09.06.2020
Verlag
Springer International Publishing
Erschienen in
Acta Neurologica Belgica / Ausgabe 4/2020
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-020-01401-7

Weitere Artikel der Ausgabe 4/2020

Acta Neurologica Belgica 4/2020 Zur Ausgabe