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03.08.2022 | COVID-19 | Original Article

Epidemiology, Clinical Profile, Intensive Care Needs and Outcome in Children with SARS-CoV-2 Infection Admitted to a Tertiary Hospital During the First and Second Waves of the COVID-19 Pandemic in India

verfasst von: Vishwa C.R., Raman Sharma, Muralidharan Jayashree, Karthi Nallasamy, Arun Bansal, Suresh Kumar Angurana, Joseph L. Mathew, Naveen Sankhyan, Sourabh Dutta, Sanjay Verma, Rakesh Kumar, Mahesh Devnanai, Pankaj C. Vaidya, Ram Samujh, Mini P. Singh, Kapil Goyal, P. V. M. Lakshmi, Akshay K. Saxena

Erschienen in: Indian Journal of Pediatrics

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Abstract

Objectives

To compare the epidemiological, clinical profile, intensive care needs and outcome of children hospitalized with SARS-CoV-2 infection during the first and second waves of the pandemic.

Methods

This was a retrospective study of all children between 1 mo and 14 y, admitted to a dedicated COVID-19 hospital (DCH) during the first (1st June to 31st December 2020) and second waves (1st March to 30th June 2021).

Results

Of 217 children, 104 (48%) and 113 (52%) were admitted during the first and second waves respectively. One hundred fifty-two (70%) had incidentally detected SARS-CoV-2 infection, while 65 (30%) had symptomatic COVID-19. Comorbidities were noted in 137 (63%) children. Fifty-nine (27%) and 66 (30%) children required high-dependency unit (HDU) and ICU care respectively. Severity of infection and ICU needs were similar during both waves. High-flow oxygen (n = 5, 2%), noninvasive ventilation [CPAP (n = 34, 16%) and BiPAP (n = 8, 5%)] and invasive ventilation (n = 45, 21%) were respiratory support therapies needed. NIV use was more during the second wave (26% vs. 13%; p = 0.02). The median (IQR) length (days) of DCH stay among survivors was longer during the first wave [8 (6–10) vs. 5.5 (3–8); p = 0.0001].

Conclusions

Disease severity, associated comorbidities, PICU and organ support need and mortality were similar in the first and second waves of the pandemic. Children admitted during the second wave were younger, had higher proportion of NIV use and shorter length of COVID-19 hospital stay.
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Metadaten
Titel
Epidemiology, Clinical Profile, Intensive Care Needs and Outcome in Children with SARS-CoV-2 Infection Admitted to a Tertiary Hospital During the First and Second Waves of the COVID-19 Pandemic in India
verfasst von
Vishwa C.R.
Raman Sharma
Muralidharan Jayashree
Karthi Nallasamy
Arun Bansal
Suresh Kumar Angurana
Joseph L. Mathew
Naveen Sankhyan
Sourabh Dutta
Sanjay Verma
Rakesh Kumar
Mahesh Devnanai
Pankaj C. Vaidya
Ram Samujh
Mini P. Singh
Kapil Goyal
P. V. M. Lakshmi
Akshay K. Saxena
Publikationsdatum
03.08.2022
Verlag
Springer India
Schlagwort
COVID-19
Erschienen in
Indian Journal of Pediatrics
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-022-04283-0

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