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Rheumatology International

Erschienen in:

28.08.2021 | COVID-19 | Review Zur Zeit gratis

COVID-19 and fertility—at the crossroads of autoimmunity and thrombosis

verfasst von: Javeria Tariq, Tulika Chatterjee, Laura Andreoli, Latika Gupta

Erschienen in: Rheumatology International | Ausgabe 11/2021

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Abstract

The SARS-CoV-2 virus is known to mediate attack via ACE-2 Receptor, thus having adverse effects on cardiovascular, respiratory, digestive and reproductive systems, the latter being an area of emerging concern, due to the associated impact on fertility, with potential for an outsized effect on population distribution and socioeconomic road map in subsequent years. This narrative review aims to put forth the current evidence of effect of SARS-CoV-2 on human fertility from a multipronged immunologic, haematologic, and gynaecologic perspective; highlighting the areas of contradiction and potential future measures. A literature search was conducted through the MEDLINE and SCOPUS databases to identify articles on the subject in English. Relevant information was extracted from around 300 articles for this review. The existing data give non-conclusive evidence about the impact of SARS-CoV-2 infection on fertility; however, a greater impact on male fertility as compared to females merits further exploration. However, reproduction and fertility is a key concern and considering the pandemic is prolonged, natural conception or ART require extra precautions.

Nur mit Berechtigung zugänglich

Aitken RJ (2021) COVID-19 and human spermatozoa—potential risks for infertility and sexual transmission? Andrology 9(1):48–52. https://doi.org/10.1111/andr.12859CrossRefPubMed

Zou X, Chen K, Zou J, Han P, Hao J, Han Z (2020) Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 14(2):185–192. https://doi.org/10.1007/s11684-020-0754-0CrossRef

El Miedany Y, Palmer D (2021) Rheumatology-led pregnancy clinic: men perspective. Clin Rheumatol 40(8):3067–3077. https://doi.org/10.1007/s10067-020-05551-0CrossRefPubMedPubMedCentral

Almeida BP, Saad CG, Souza FH, Moraes JC, Nukumizu LA, Viana VS, Bonfá E, Silva CA (2013) Testicular sertoli cell function in ankylosing spondylitis. Clin Rheumatol 32(7):1075–1079. https://doi.org/10.1007/s10067-013-2215-5CrossRefPubMed

Rajaei E, Shahbazian N, Rezaeeyan H, Mohammadi AK, Hesam S, Zayeri ZD (2019) The effect of lupus disease on the pregnant women and embryos: a retrospective study from 2010 to 2014. Clin Rheumatol 38(11):3211–3215. https://doi.org/10.1007/s10067-019-04682-3CrossRefPubMed

Tomioka RB, Ferreira GRV, Aikawa NE, Maciel GAR, Serafini PC, Sallum AM, Campos LMA, Goldestein-Schainberg C, Bonfá E, Silva CA (2018) Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients. Clin Rheumatol 37(10):2869–2873. https://doi.org/10.1007/s10067-018-4208-xCrossRefPubMed

Jutiviboonsuk A, Salang L, Eamudomkarn N, Mahakkanukrauh A, Suwannaroj S, Foocharoen C (2021) Prevalence and clinical associations with premature ovarian insufficiency, early menopause, and low ovarian reserve in systemic sclerosis. Clin Rheumatol 40(6):2267–2275. https://doi.org/10.1007/s10067-020-05522-5CrossRefPubMed

Fan C, Lu W, Li K, Ding Y, Wang J (2021) ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 patients. Front Med 7:563893. https://doi.org/10.3389/fmed.2020.563893CrossRef

Gomes PRC, da Rocha MDR, da Coelho FAR, Pinho S, de Lira JA, de Sousa Carmo RR, Nascimento HMS, de Oliveira SM, da Silva WR, Medeiros RG, Alves EHP, Dos Santos CA, Vasconcelos DFP (2021) Alterations of the male and female reproductive systems induced by COVID-19. Wien Klin Wochenschr 28:1–7. https://doi.org/10.1007/s00508-021-01875-2CrossRef

10.

Aassve A, Cavalli N, Mencarini L, Plach S, Bacci ML (2020) The COVID-19 pandemic and human fertility. Science 369(6502):370–371. https://doi.org/10.1126/science.abc9520CrossRefPubMed

11.

Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, Fei C (2020) Potential influence of COVID-19/ACE2 on the female reproductive system. Mol Hum Reprod 26(6):367–373. https://doi.org/10.1093/molehr/gaaa030CrossRefPubMed

12.

Huang HH, Wang PH, Yang YP, Chou SJ, Chu PW, Wu GJ, Chang CC (2020) A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system. J Chin Med Assoc 83(10):895–897. https://doi.org/10.1097/JCMA.0000000000000388CrossRefPubMedPubMedCentral

13.

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, Yang J (2020) Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA 323(18):1846–1848. https://doi.org/10.1001/jama.2020.4621CrossRefPubMedPubMedCentral

14.

Ding T, Wang T, Zhang J, Cui P, Chen Z, Zhou S, Yuan S, Ma W, Zhang M, Rong Y, Chang J, Miao X, Ma X, Wang S (2021) Analysis of ovarian injury associated with COVID-19 disease in reproductive-aged women in Wuhan, China: an observational study. Front Med 8:635255. https://doi.org/10.3389/fmed.2021.635255CrossRef

15.

Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, Lee S, Wang C, Li H, Cheng L, Ai J (2021) Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online 42(1):260–267. https://doi.org/10.1016/j.rbmo.2020.09.020CrossRefPubMed

16.

Li R, Yin T, Fang F, Li Q, Chen J, Wang Y, Hao Y, Wu G, Duan P, Wang Y, Cheng D, Zhou Q, Zafar MI, Xiong C, Li H, Yang J, Qiao J (2020) Potential risks of SARS-CoV-2 infection on reproductive health. Reprod Biomed Online 41(1):89–95. https://doi.org/10.1016/j.rbmo.2020.04.018CrossRefPubMedPubMedCentral

17.

Kaya Y, Kaya C, Tahta T, Kartal T, Tokgöz VY (2021) Examination of the effect of COVID-19 on sexual dysfunction in women. Int J Clin Pract 75(3):e13923. https://doi.org/10.1111/ijcp.13923CrossRefPubMed

18.

Batiha O, Al-Deeb T, Al-Zoubi E, Alsharu E (2020) Impact of COVID-19 and other viruses on reproductive health. Andrologia 52(9):e13791. https://doi.org/10.1111/and.13791CrossRefPubMed

19.

Wang Z, Xu X (2020) scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells. Cells 9(4):920. https://doi.org/10.3390/cells9040920CrossRefPubMedCentral

20.

Ma L, Xie W, Li D, Shi L, Mao Y, Xiong Y et al (2020) Effect of SARS-CoV-2 infection upon male gonadal function: a single center-based study. medRxiv. https://doi.org/10.1101/2020.03.21.20037267CrossRefPubMedPubMedCentral

21.

Salonia A, Pontillo M, Capogrosso P, Gregori S, Tassara M, Boeri L, Carenzi C, Abbate C, Cignoli D, Ferrara AM, Cazzaniga W, Rowe I, Ramirez GA, Tresoldi C, Mushtaq J, Locatelli M, Santoleri L, Castagna A, Zangrillo A, De Cobelli F, Tresoldi M, Landoni G, Rovere-Querini P, Ciceri F, Montorsi F (2021) Severely low testosterone in males with COVID-19: a case-control study. Andrology 9(4):1043–1052. https://doi.org/10.1111/andr.12993CrossRefPubMed

22.

Schroeder M, Schaumburg B, Müller Z et al (2020) Sex hormone and metabolic dysregulations are associated with critical. medRxiv. https://doi.org/10.1101/2020.05.07.20073817CrossRef

23.

Holtmann N, Edimiris P, Andree M et al (2020) Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril 114(2):233–238. https://doi.org/10.1016/j.fertnstert.2020.05.028CrossRefPubMedPubMedCentral

24.

Li H, Xiao X, Zhang J, Zafar MI, Wu C, Long Y, Lu W, Pan F, Meng T, Zhao K, Zhou L, Shen S, Liu L, Liu Q, Xiong C (2020) Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine 28:100604. https://doi.org/10.1016/j.eclinm.2020.100604CrossRefPubMedPubMedCentral

25.

Kharbach Y, Khallouk A (2021) Male genital damage in COVID-19 patients: are available data relevant? Asian J Urol 8(3):324–326. https://doi.org/10.1016/j.ajur.2020.06.005CrossRefPubMed

26.

José FG, González JGÁ, Molina JMC et al (2020) SARS-CoV-2 infection: implications for sexual and reproductive health. A position statement of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA). Revista Internacional de Andrologia 18(3):117–123. https://doi.org/10.1016/j.androl.2020.06.001CrossRefPubMedPubMedCentral

27.

Sergerie M, Mieusset R, Croute F, Daudin M, Bujan L (2007) High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertil Steril 88(4):970. https://doi.org/10.1016/j.fertnstert.2006.12.045CrossRefPubMed

28.

Omolaoye TS, Adeniji AA, Maya WDC, du Plessis SS (2021) SARS-COV-2 (COVID-19) and male fertility: where are we? Reprod Toxicol (Elmsford, NY) 99:65–70. https://doi.org/10.1016/j.reprotox.2020.11.012CrossRef

29.

Song C, Wang Y, Li W, Hu B, Chen G, Xia P, Wang W, Li C, Diao F, Hu Z, Yang X, Yao B, Liu Y (2020) Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients†. Biol Reprod 103(1):4–6. https://doi.org/10.1093/biolre/ioaa050CrossRefPubMed

30.

Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O, Antonelli G, Lenzi A, Lombardo F (2020) Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest 43(12):1819–1822. https://doi.org/10.1007/s40618-020-01261-1CrossRefPubMed

31.

Ning J, Li W, Ruan Y, Xia Y, Wu X, Hu K, Ding X, Wu X, Yu L, Zhou J, Mao Z, Xu W, Yu W, Cheng F (2020) Effects of 2019 novel coronavirus on male reproductive system: a retrospective study. Preprints. https://doi.org/10.20944/preprints202004.0280.v1CrossRef

32.

Li D, Jin M, Bao P, Zhao W, Zhang S (2020) Clinical characteristics and results of semen tests among men with coronavirus disease 2019. JAMA Netw Open 3(5):e208292. https://doi.org/10.1001/jamanetworkopen.2020.8292CrossRefPubMedPubMedCentral

33.

Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, Spivak AM, Alukal JP, Zhang X, Xiong C, Li PS, Hotaling JM (2020) No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril 113(6):1135–1139. https://doi.org/10.1016/j.fertnstert.2020.04.024CrossRefPubMedPubMedCentral

34.

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y (2020) Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet (London, England) 395(10226):809–815. https://doi.org/10.1016/S0140-6736(20)30360-3CrossRef

35.

Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z (2020) Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med 14(2):193–198. https://doi.org/10.1007/s11684-020-0772-yCrossRefPubMed

36.

Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, Liu Y, Xiao J, Liu H, Deng D, Chen S, Zeng W, Feng L, Wu J (2020) Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis 20(5):559–564. https://doi.org/10.1016/S1473-3099(20)30176-6CrossRefPubMedPubMedCentral

37.

Sharps MC, Hayes DJL, Lee S, Zou Z, Brady CA, Almoghrabi Y, Kerby A, Tamber KK, Jones CJ, Adams Waldorf KM, Heazell AEP (2020) A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta 101:13–29. https://doi.org/10.1016/j.placenta.2020.08.018CrossRefPubMedPubMedCentral

38.

Celik O, Saglam A, Baysal B, Derwig IE, Celik N, Ak M, Aslan SN, Ulas M, Ersahin A, Tayyar AT, Duran B, Aydin S (2020) Factors preventing materno-fetal transmission of SARS-CoV-2. Placenta 97:1–5. https://doi.org/10.1016/j.placenta.2020.05.012CrossRefPubMedPubMedCentral

39.

Schwartz DA (2020) An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med 144(7):799–805. https://doi.org/10.5858/arpa.2020-0901-SACrossRefPubMed

40.

Baud D, Greub G, Favre G, Gengler C, Jaton K, Dubruc E, Pomar L (2020) Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA 323(21):2198–2200. https://doi.org/10.1001/jama.2020.7233CrossRefPubMedPubMedCentral

41.

Menter T, Mertz KD, Jiang S, Chen H, Monod C, Tzankov A, Waldvogel S, Schulzke SM, Hösli I, Bruder E (2021) Placental pathology findings during and after SARS-CoV-2 infection: features of villitis and malperfusion. Pathobiology 88(1):69–77. https://doi.org/10.1159/000511324CrossRefPubMed

42.

Man J, Hutchinson JC, Heazell AE, Ashworth M, Jeffrey I, Sebire NJ (2016) Stillbirth and intrauterine fetal death: role of routine histopathological placental findings to determine cause of death. Ultrasound Obstet Gynecol 48(5):579–584. https://doi.org/10.1002/uog.16019CrossRefPubMed

43.

Baergen RN, Heller DS (2020) Placental pathology in COVID-19 positive mothers: preliminary findings. Pediatr Dev Pathol 23(3):177–180. https://doi.org/10.1177/1093526620925569CrossRefPubMedPubMedCentral

44.

Sharma I, Kumari P, Sharma A, Saha SC (2021) SARS-CoV-2 and the reproductive system: known and the unknown..!! Middle East Fertil Soc J 26(1):1. https://doi.org/10.1186/s43043-020-00046-zCrossRefPubMedPubMedCentral

45.

Pereira A, Cruz-Melguizo S, Adrien M, Fuentes L, Marin E, Forti A, Perez-Medina T (2020) Breastfeeding mothers with COVID-19 infection: a case series. Int Breastfeed J 15(1):69. https://doi.org/10.1186/s13006-020-00314-8CrossRefPubMedPubMedCentral

46.

Caso F, Costa L, Ruscitti P, Navarini L, Del Puente A, Giacomelli R, Scarpa R (2020) Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects? Autoimmun Rev 19(5):102524. https://doi.org/10.1016/j.autrev.2020.102524CrossRefPubMedPubMedCentral

47.

Ehrenfeld M, Tincani A, Andreoli L, Cattalini M, Greenbaum A, Kanduc D, Alijotas-Reig J, Zinserling V, Semenova N, Amital H, Shoenfeld Y (2020) COVID-19 and autoimmunity. Autoimmun Rev 19(8):102597. https://doi.org/10.1016/j.autrev.2020.102597CrossRefPubMedPubMedCentral

48.

Sacchi MC, Tamiazzo S, Stobbione P, Agatea L, De Gaspari P, Stecca A, Lauritano EC, Roveta A, Tozzoli R, Guaschino R, Bonometti R (2021) SARS-CoV-2 infection as a trigger of autoimmune response. Clin Transl Sci 14(3):898–907. https://doi.org/10.1111/cts.12953CrossRefPubMedPubMedCentral

49.

Wang EY, Mao T, Klein J, Dai Y, Huck JD, Jaycox JR, Liu F, Zhou T, Israelow B, Wong P, Coppi A, Lucas C, Silva J, Oh JE, Song E, Perotti ES, Zheng NS, Fischer S, Campbell M, Fournier JB, Wyllie AL, Vogels CBF, Ott IM, Kalinich CC, Petrone ME, Watkins AE, Yale IMPACT Team, Cruz CD, Farhadian SF, Schulz WL, Ma S, Grubaugh ND, Ko AI, Iwasaki A, Ring AM (2021) Diverse functional autoantibodies in patients with COVID-19. Nature 595(7866):283–288. https://doi.org/10.1038/s41586-021-03631-yCrossRefPubMed

50.

Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Chen H, Ding X, Zhao H, Zhang H, Wang C, Zhao J, Sun X, Tian R, Wu W, Wu D, Ma J, Chen Y, Zhang D, Xie J, Yan X, Zhou X, Liu Z, Wang J, Du B, Qin Y, Gao P, Qin X, Xu Y, Zhang W, Li T, Zhang F, Zhao Y, Li Y, Zhang S (2020) Coagulopathy and antiphospholipid antibodies in patients with COVID-19. N Engl J Med 382(17):e38. https://doi.org/10.1056/NEJMc2007575CrossRefPubMed

51.

Mohammadi S, Abouzaripour M, Hesam Shariati N, Hesam Shariati MB (2020) Ovarian vein thrombosis after coronavirus disease (COVID-19) infection in a pregnant woman: case report. J Thromb Thrombolysis 50(3):604–607. https://doi.org/10.1007/s11239-020-02177-6CrossRefPubMed

52.

Shoenfeld Y, Blank M, Cervera R, Font J, Raschi E, Meroni PL (2006) Infectious origin of the antiphospholipid syndrome. Ann Rheum Dis 65(1):2–6. https://doi.org/10.1136/ard.2005.045443CrossRefPubMedPubMedCentral

53.

Revannasiddaiah S, Kumar Devadas S, Palassery R, Kumar Pant N, Maka VV (2020) A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2. Med Hypotheses 144:109850. https://doi.org/10.1016/j.mehy.2020.109850CrossRefPubMedPubMedCentral

54.

Gupta R, Deepanjali S, Kumar A, Dadhwal V, Agarwal SK, Pandey RM, Chaturvedi PK (2010) A comparative study of pregnancy outcomes and menstrual irregularities in northern Indian patients with systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int 30(12):1581–1585. https://doi.org/10.1007/s00296-009-1192-0CrossRefPubMed

55.

Pedersen SF, Ho YC (2020) SARS-CoV-2: a storm is raging. J Clin Investig 130(5):2202–2205. https://doi.org/10.1172/JCI137647CrossRefPubMedPubMedCentral

56.

Maiorino MI, Bellastella G, Giugliano D, Esposito K (2018) From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest 41(11):1249–1258. https://doi.org/10.1007/s40618-018-0872-6CrossRefPubMed

57.

Mehta P, Fajgenbaum DC (2021) Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate. Curr Opin Rheumatol. https://doi.org/10.1097/BOR.0000000000000822 (Advance online publication)CrossRefPubMedPubMedCentral

58.

Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F (2014) Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in sertoli cells. Sci Rep 4:4260. https://doi.org/10.1038/srep042604CrossRefPubMedPubMedCentral

59.

Corona G, Baldi E, Isidori AM, Paoli D, Pallotti F, De Santis L, Francavilla F, La Vignera S, Selice R, Caponecchia L, Pivonello R, Ferlin A, Foresta C, Jannini EA, Lenzi A, Maggi M, Lombardo F (2020) SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità). J Endocrinol Invest 43(8):1153–1157. https://doi.org/10.1007/s40618-020-01290-wCrossRefPubMed

60.

Huang C, Ji X, Zhou W, Huang Z, Peng X, Fan L, Lin G, Zhu W (2021) Coronavirus: a possible cause of reduced male fertility. Andrology 9(1):80–87. https://doi.org/10.1111/andr.12907CrossRefPubMed

61.

Leisman DE, Deutschman CS, Legrand M (2020) Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med 46(6):1105–1108. https://doi.org/10.1007/s00134-020-06059-6CrossRefPubMed

62.

Xu J, Qi L, Chi X, Yang J, Wei X, Gong E, Peh S, Gu J (2006) Orchitis: a complication of severe acute respiratory syndrome (SARS). Biol Reprod 74(2):410–416. https://doi.org/10.1095/biolreprod.105.044776CrossRefPubMed

63.

Itoh M, Hiramine C, Tokunaga Y, Mukasa A, Hojo K (1991) A new murine model of autoimmune orchitis induced by immunization with viable syngeneic testicular germ cells alone. II. Immunohistochemical findings of fully-developed inflammatory lesion. Autoimmunity 10(2):89–97. https://doi.org/10.3109/08916939109004812CrossRefPubMed

64.

Connell NT, Battinelli EM, Connors JM (2020) Coagulopathy of COVID-19 and antiphospholipid antibodies. J Thromb Haemost. https://doi.org/10.1111/jth.14893 (Advance online publication)CrossRefPubMedPubMedCentral

65.

Long QX, Liu BZ, Deng HJ, Wu GC, Deng K, Chen YK, Liao P, Qiu JF, Lin Y, Cai XF, Wang DQ, Hu Y, Ren JH, Tang N, Xu YY, Yu LH, Mo Z, Gong F, Zhang XL, Tian WG, Hu L, Zhang XX, Xiang JL, Du HX, Liu HW, Lang CH, Luo XH, Wu SB, Cui XP, Zhou Z, Zhu MM, Wang J, Xue CJ, Li XF, Wang L, Li ZJ, Wang K, Niu CC, Yang QJ, Tang XJ, Zhang Y, Liu XM, Li JJ, Zhang DC, Zhang F, Liu P, Yuan J, Li Q, Hu JL, Chen J, Huang AL (2020) Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med 26(6):845–848. https://doi.org/10.1038/s41591-020-0897-1CrossRefPubMed

66.

Chiu WW, Chamley LW (2004) Clinical associations and mechanisms of action of antisperm antibodies. Fertil Steril 82(3):529–535. https://doi.org/10.1016/j.fertnstert.2003.09.084CrossRefPubMed

67.

Mohkhedkar M, Venigalla SSK, Janakiraman V (2021) Untangling COVID-19 and autoimmunity: identification of plausible targets suggests multi organ involvement. Mol Immunol 137:105–113. https://doi.org/10.1016/j.molimm.2021.06.021CrossRefPubMedPubMedCentral

68.

Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL (2021) Long COVID in patients with mild to moderate disease: do thyroid function and autoimmunity play a role? Endocr Pract. https://doi.org/10.1016/j.eprac.2021.06.016 (Advance online publication)CrossRefPubMedPubMedCentral

69.

Lingel H, Meltendorf S, Billing U, Thurm C, Vogel K, Majer C, Prätsch F, Roggenbuck D, Heuft HG, Hachenberg T, Feist E, Reinhold D, Brunner-Weinzierl MC (2021) Unique autoantibody prevalence in long-term recovered SARS-CoV-2-infected individuals. J Autoimmun 122:102682. https://doi.org/10.1016/j.jaut.2021.102682CrossRefPubMedPubMedCentral

70.

Saud A, Naveen R, Aggarwal R, Gupta L (2021) COVID-19 and myositis: what we know so far. Curr Rheumatol Rep 23(8):63. https://doi.org/10.1007/s11926-021-01023-9CrossRefPubMedPubMedCentral

71.

Zuo Y, Yalavarthi S, Navaz SA, Hoy CK, Harbaugh A, Gockman K, Zuo M, Madison JA, Shi H, Kanthi Y, Knight JS (2021) Autoantibodies stabilize neutrophil extracellular traps in COVID-19. JCI Insight 6(15):150111. https://doi.org/10.1172/jci.insight.150111CrossRefPubMed

Titel: COVID-19 and fertility—at the crossroads of autoimmunity and thrombosis
verfasst von: Javeria Tariq
Tulika Chatterjee
Laura Andreoli
Latika Gupta
Publikationsdatum: 28.08.2021
Verlag: Springer Berlin Heidelberg
Schlagwörter: COVID-19
Fertilität und Kinderwunsch
Pneumonie
Infektionen in der HNO-Heilkunde
Infektionserkrankungen in der Hausarztpraxis
Infektionen in der Intensivmedizin
Andrologie
Erschienen in: Rheumatology International / Ausgabe 11/2021
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-021-04977-2

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