Skip to main content
Erschienen in:

04.06.2022 | COVID-19 | Systematic review

Gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and meta-analysis

verfasst von: Sepideh Benvari, Shima Mahmoudi, Mohsen Mohammadi

Erschienen in: World Journal of Pediatrics | Ausgabe 9/2022

Einloggen, um Zugang zu erhalten

Abstract

Background

Coronavirus disease 2019 (COVID-19) has different manifestations in pediatric cases. It is assumed that they might present more gastrointestinal symptoms with a different viral shedding pattern in gastrointestinal samples. In this systematic review and meta-analysis, we aimed to evaluate the viral shedding pattern in gastrointestinal specimens of children with COVID-19.

Methods

We searched all published studies in English language in PubMed, Web of Science, and Scopus, up to date as of October 2021. Our search included the term "severe acute respiratory syndrome coronavirus 2, COVID-19, SARS-CoV-2, novel coronavirus, or coronavirus; and shed, excrete, secret, or carriage; and stool or rectal; and children or pediatrics". We included studies evaluating SARS-CoV-2 shedding in gastrointestinal specimens, including rectal swabs and stool samples of children with COVID-19 infection. We excluded duplicated data, case reports, and studies without original data.

Results

Twelve studies met the eligibility criteria for the qualitative synthesis, 10 of which were included in the meta-analysis. The pooled prevalence of gastrointestinal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in children with COVID-19 was 86% (95% confidence interval 73%–96%, I2 = 62.28%). After respiratory specimen had become negative, 72% (43/60) had persistent shedding in gastrointestinal specimens. The gastrointestinal RNA had a positive test result for more than 70 days after symptoms onset.

Conclusions

Gastrointestinal shedding of SARS-CoV-2 might occur in a substantial portion of children and might persist long after negative respiratory testing. Further research is recommended to find the role of SARS-CoV-2 gastrointestinal shedding in transmission in children.
Literatur
1.
Zurück zum Zitat Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–33.PubMedPubMedCentralCrossRef Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–33.PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–20.PubMedCrossRef Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–20.PubMedCrossRef
3.
Zurück zum Zitat Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115:766–73.PubMedCrossRef Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115:766–73.PubMedCrossRef
4.
Zurück zum Zitat Mahmoudi S, Mehdizadeh M, Shervin Badv R, Navaeian A, Pourakbari B, Rostamyan M, et al. The coronavirus disease 2019 (COVID-19) in children: a study in an Iranian Children’s Referral Hospital. Infect Drug Resist. 2020;13:2649–55.PubMedPubMedCentralCrossRef Mahmoudi S, Mehdizadeh M, Shervin Badv R, Navaeian A, Pourakbari B, Rostamyan M, et al. The coronavirus disease 2019 (COVID-19) in children: a study in an Iranian Children’s Referral Hospital. Infect Drug Resist. 2020;13:2649–55.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Ekbatani MS, Hassani SA, Tahernia L, Yaghmaei B, Mahmoudi S, Navaeian A, et al. Atypical and novel presentations of coronavirus disease 2019: a case series of three children. Br J Biomed Sci. 2021;78:47–52.PubMedCrossRef Ekbatani MS, Hassani SA, Tahernia L, Yaghmaei B, Mahmoudi S, Navaeian A, et al. Atypical and novel presentations of coronavirus disease 2019: a case series of three children. Br J Biomed Sci. 2021;78:47–52.PubMedCrossRef
6.
Zurück zum Zitat Mamishi S, Movahedi Z, Mohammadi M, Ziaee V, Khodabandeh M, Abdolsalehi MR, et al. Multisystem inflammatory syndrome associated with SARS-CoV-2 infection in 45 children: a first report from Iran. Epidemiol Infect. 2020;148:e196.PubMedCrossRef Mamishi S, Movahedi Z, Mohammadi M, Ziaee V, Khodabandeh M, Abdolsalehi MR, et al. Multisystem inflammatory syndrome associated with SARS-CoV-2 infection in 45 children: a first report from Iran. Epidemiol Infect. 2020;148:e196.PubMedCrossRef
7.
Zurück zum Zitat Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Carducci FIC, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4:653–61.PubMedPubMedCentralCrossRef Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Carducci FIC, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4:653–61.PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations: scientific brief, 29 March 2020 (No. WHO/2019-nCoV/Sci_Brief/Transmission_modes/2020.1). 2020. World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations: scientific brief, 29 March 2020 (No. WHO/2019-nCoV/Sci_Brief/Transmission_modes/2020.1). 2020.
9.
Zurück zum Zitat Pourakbari B, Mahmoudi S, Mahmoudieh Y, Eshaghi H, Navaeian A, Rostamyan M, et al. SARS-CoV-2 RNAaemia in children: an Iranian referral hospital-based study. J Med Virol. 2021;93:5452–7.PubMedPubMedCentralCrossRef Pourakbari B, Mahmoudi S, Mahmoudieh Y, Eshaghi H, Navaeian A, Rostamyan M, et al. SARS-CoV-2 RNAaemia in children: an Iranian referral hospital-based study. J Med Virol. 2021;93:5452–7.PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Ling Y, Xu SB, Lin YX, Tian D, Zhu ZQ, Dai FH, et al. Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin Med J (Engl). 2020;133:1039–43.CrossRef Ling Y, Xu SB, Lin YX, Tian D, Zhu ZQ, Dai FH, et al. Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin Med J (Engl). 2020;133:1039–43.CrossRef
11.
Zurück zum Zitat Wu Y, Guo C, Tang L, Hong Z, Zhou J, Dong X, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol. 2020;5:434–5.PubMedPubMedCentralCrossRef Wu Y, Guo C, Tang L, Hong Z, Zhou J, Dong X, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol. 2020;5:434–5.PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Chen Y, Chen L, Deng Q, Zhang G, Wu K, Ni L, et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. J Med Virol. 2020;92:833–40.PubMedCrossRef Chen Y, Chen L, Deng Q, Zhang G, Wu K, Ni L, et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. J Med Virol. 2020;92:833–40.PubMedCrossRef
13.
Zurück zum Zitat van Doorn AS, Meijer B, Frampton CM, Barclay ML, de Boer NK. Systematic review with meta-analysis: SARS-CoV-2 stool testing and the potential for faecal-oral transmission. Aliment Pharmacol Ther. 2020;52:1276–88.PubMedPubMedCentral van Doorn AS, Meijer B, Frampton CM, Barclay ML, de Boer NK. Systematic review with meta-analysis: SARS-CoV-2 stool testing and the potential for faecal-oral transmission. Aliment Pharmacol Ther. 2020;52:1276–88.PubMedPubMedCentral
14.
Zurück zum Zitat Yan D, Zhang X, Chen C, Jiang D, Liu X, Zhou Y, et al. Characteristics of viral shedding time in SARS-CoV-2 infections: a systematic review and meta-analysis. Front Public Health. 2021;9:652842.PubMedPubMedCentralCrossRef Yan D, Zhang X, Chen C, Jiang D, Liu X, Zhou Y, et al. Characteristics of viral shedding time in SARS-CoV-2 infections: a systematic review and meta-analysis. Front Public Health. 2021;9:652842.PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Parasa S, Desai M, Thoguluva Chandrasekar V, Patel HK, Kennedy KF, Roesch T, et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2011335.PubMedPubMedCentralCrossRef Parasa S, Desai M, Thoguluva Chandrasekar V, Patel HK, Kennedy KF, Roesch T, et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2011335.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Zhang Y, Cen M, Hu M, Du L, Hu W, Kim JJ, et al. Prevalence and persistent shedding of fecal SARS-CoV-2 RNA in patients with COVID-19 infection: a systematic review and meta-analysis. Clin Transl Gastroenterol. 2021;12:e00343.PubMedPubMedCentralCrossRef Zhang Y, Cen M, Hu M, Du L, Hu W, Kim JJ, et al. Prevalence and persistent shedding of fecal SARS-CoV-2 RNA in patients with COVID-19 infection: a systematic review and meta-analysis. Clin Transl Gastroenterol. 2021;12:e00343.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Ma X, Su L, Zhang Y, Zhang X, Gai Z, Zhang Z. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol Immunol Infect. 2020;53:373–6.PubMedPubMedCentralCrossRef Ma X, Su L, Zhang Y, Zhang X, Gai Z, Zhang Z. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol Immunol Infect. 2020;53:373–6.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China–the character of children with COVID-19. Emerg Microbes Infect. 2020;9:707–13.PubMedCrossRef Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China–the character of children with COVID-19. Emerg Microbes Infect. 2020;9:707–13.PubMedCrossRef
19.
Zurück zum Zitat de Souza TH, Nadal JA, Nogueira RJ, Pereira RM, Brandão MB. Clinical manifestations of children with COVID-19: a systematic review. Pediatr Pulmonol. 2020;55:1892–9.PubMedPubMedCentralCrossRef de Souza TH, Nadal JA, Nogueira RJ, Pereira RM, Brandão MB. Clinical manifestations of children with COVID-19: a systematic review. Pediatr Pulmonol. 2020;55:1892–9.PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Xing YH, Ni W, Wu Q, Li WJ, Li GJ, Wang WD, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. J Microbiol Immunol Infect. 2020;53:473–80.PubMedPubMedCentralCrossRef Xing YH, Ni W, Wu Q, Li WJ, Li GJ, Wang WD, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. J Microbiol Immunol Infect. 2020;53:473–80.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777–84.PubMedCrossRef Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777–84.PubMedCrossRef
22.
Zurück zum Zitat Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25.PubMedPubMedCentralCrossRef Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25.PubMedPubMedCentralCrossRef
23.
Zurück zum Zitat Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.PubMedCrossRef Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.PubMedCrossRef
24.
Zurück zum Zitat Zhang Y, Chen C, Song Y, Zhu S, Wang D, Zhang H, et al. Excretion of SARS-CoV-2 through faecal specimens. Emerg Microbes Infect. 2020;9:2501–8.PubMedPubMedCentralCrossRef Zhang Y, Chen C, Song Y, Zhu S, Wang D, Zhang H, et al. Excretion of SARS-CoV-2 through faecal specimens. Emerg Microbes Infect. 2020;9:2501–8.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Kipkorir V, Cheruiyot I, Ngure B, Misiani M, Munguti J. Prolonged SARS-CoV-2 RNA detection in anal/rectal swabs and stool specimens in COVID-19 patients after negative conversion in nasopharyngeal RT-PCR test. J Med Virol. 2020;92:2328–31.PubMedPubMedCentralCrossRef Kipkorir V, Cheruiyot I, Ngure B, Misiani M, Munguti J. Prolonged SARS-CoV-2 RNA detection in anal/rectal swabs and stool specimens in COVID-19 patients after negative conversion in nasopharyngeal RT-PCR test. J Med Virol. 2020;92:2328–31.PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Cai J, Wang X, Zhao J, Ge Y, Xu J, Tian H, et al. Comparison of clinical and epidemiological characteristics of asymptomatic and symptomatic SARS-CoV-2 infection in children. Virol Sin. 2020;35:803–10.PubMedPubMedCentralCrossRef Cai J, Wang X, Zhao J, Ge Y, Xu J, Tian H, et al. Comparison of clinical and epidemiological characteristics of asymptomatic and symptomatic SARS-CoV-2 infection in children. Virol Sin. 2020;35:803–10.PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Hua CZ, Miao ZP, Zheng JS, Huang Q, Sun QF, Lu HP, et al. Epidemiological features and viral shedding in children with SARS-CoV-2 infection. J Med Virol. 2020;92:2804–12.PubMedPubMedCentralCrossRef Hua CZ, Miao ZP, Zheng JS, Huang Q, Sun QF, Lu HP, et al. Epidemiological features and viral shedding in children with SARS-CoV-2 infection. J Med Virol. 2020;92:2804–12.PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Tan YP, Tan BY, Pan J, Wu J, Zeng SZ, Wei HY. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha. China. J Clin Virol. 2020;127:104353.PubMedCrossRef Tan YP, Tan BY, Pan J, Wu J, Zeng SZ, Wei HY. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha. China. J Clin Virol. 2020;127:104353.PubMedCrossRef
29.
Zurück zum Zitat Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26:502–5.PubMedPubMedCentralCrossRef Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26:502–5.PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Liu P, Cai J, Jia R, Xia S, Wang X, Cao L, et al. Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19. Emerg Microbes Infect. 2020;9:1254–8.PubMedPubMedCentralCrossRef Liu P, Cai J, Jia R, Xia S, Wang X, Cao L, et al. Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19. Emerg Microbes Infect. 2020;9:1254–8.PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Ma X, Su L, Cheng L, Zhang Z, Sun J, Liu M, et al. Severe acute respiratory syndrome coronavirus 2 viral load in respiratory and feces specimens of children with coronavirus disease 2019. Future Virol. 2021;16:85–91.CrossRef Ma X, Su L, Cheng L, Zhang Z, Sun J, Liu M, et al. Severe acute respiratory syndrome coronavirus 2 viral load in respiratory and feces specimens of children with coronavirus disease 2019. Future Virol. 2021;16:85–91.CrossRef
32.
Zurück zum Zitat Wolf GK, Glueck T, Huebner J, Muenchhoff M, Hoffmann D, French LE, et al. Clinical and epidemiological features of a family cluster of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 infection. J Pediatric Infect Dis Soc. 2020;9:362–5.PubMedCrossRef Wolf GK, Glueck T, Huebner J, Muenchhoff M, Hoffmann D, French LE, et al. Clinical and epidemiological features of a family cluster of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 infection. J Pediatric Infect Dis Soc. 2020;9:362–5.PubMedCrossRef
33.
Zurück zum Zitat Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;71:1547–51.CrossRef Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;71:1547–51.CrossRef
34.
Zurück zum Zitat De Ioris MA, Scarselli A, Ciofi degli Atti ML, Ravà L, Smarrazzo A, Concato C, et al. Dynamic viral severe acute respiratory syndrome coronavirus 2 RNA shedding in children: preliminary data and clinical consideration of Italian regional center. J Pediatric Infect Dis Soc. 2020;9:366–9.PubMedCrossRef De Ioris MA, Scarselli A, Ciofi degli Atti ML, Ravà L, Smarrazzo A, Concato C, et al. Dynamic viral severe acute respiratory syndrome coronavirus 2 RNA shedding in children: preliminary data and clinical consideration of Italian regional center. J Pediatric Infect Dis Soc. 2020;9:366–9.PubMedCrossRef
35.
Zurück zum Zitat Wang JG, Cui HR, Tang HB, Deng XL. Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis. Sci Rep. 2020;10:17846.PubMedPubMedCentralCrossRef Wang JG, Cui HR, Tang HB, Deng XL. Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis. Sci Rep. 2020;10:17846.PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, et al. SARS-CoV-2–related MIS-C: a key to the viral and genetic causes of Kawasaki disease? J Exp Med. 2021;218:e20210446.PubMedPubMedCentralCrossRef Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, et al. SARS-CoV-2–related MIS-C: a key to the viral and genetic causes of Kawasaki disease? J Exp Med. 2021;218:e20210446.PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Zare-Zardini H, Soltaninejad H, Ferdosian F, Hamidieh AA, Memarpoor-Yazdi M. Coronavirus disease 2019 (COVID-19) in children: prevalence, diagnosis, clinical symptoms, and treatment. Int J Gen Med. 2020;13:477–82.PubMedPubMedCentralCrossRef Zare-Zardini H, Soltaninejad H, Ferdosian F, Hamidieh AA, Memarpoor-Yazdi M. Coronavirus disease 2019 (COVID-19) in children: prevalence, diagnosis, clinical symptoms, and treatment. Int J Gen Med. 2020;13:477–82.PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Mamishi S, Heydari H, Aziz-Ahari A, Shokrollahi MR, Pourakbari B, Mahmoudi S, et al. Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: atypical CT manifestations and mortality risk of severe COVID-19 infection. J Microbiol Immunol Infect. 2021;54:839–44.PubMedCrossRef Mamishi S, Heydari H, Aziz-Ahari A, Shokrollahi MR, Pourakbari B, Mahmoudi S, et al. Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: atypical CT manifestations and mortality risk of severe COVID-19 infection. J Microbiol Immunol Infect. 2021;54:839–44.PubMedCrossRef
39.
Zurück zum Zitat Xu CL, Raval M, Schnall JA, Kwong JC, Holmes NE. Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data. Pediatr Infect Dis J. 2020;39:e249–56.PubMedCrossRef Xu CL, Raval M, Schnall JA, Kwong JC, Holmes NE. Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data. Pediatr Infect Dis J. 2020;39:e249–56.PubMedCrossRef
40.
Zurück zum Zitat Cheung KS, Hung IFN, Chan PPY, Lung KC, Tso E, Liu R, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology. 2020;159:81–95.PubMedCrossRef Cheung KS, Hung IFN, Chan PPY, Lung KC, Tso E, Liu R, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology. 2020;159:81–95.PubMedCrossRef
41.
Zurück zum Zitat Al-Beltagi M, Saeed NK, Bediwy AS, El-Sawaf Y. Paediatric gastrointestinal disorders in SARS-CoV-2 infection: epidemiological and clinical implications. World J Gastroenterol. 2021;27:1716–27.PubMedPubMedCentralCrossRef Al-Beltagi M, Saeed NK, Bediwy AS, El-Sawaf Y. Paediatric gastrointestinal disorders in SARS-CoV-2 infection: epidemiological and clinical implications. World J Gastroenterol. 2021;27:1716–27.PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Hao S, Lian J, Lu Y, Jia H, Hu J, Yu G, et al. Decreased B cells on admission associated with prolonged viral RNA shedding from the respiratory tract in coronavirus disease 2019: a case–control study. J Infect Dis. 2020;222:367–71.PubMedCrossRef Hao S, Lian J, Lu Y, Jia H, Hu J, Yu G, et al. Decreased B cells on admission associated with prolonged viral RNA shedding from the respiratory tract in coronavirus disease 2019: a case–control study. J Infect Dis. 2020;222:367–71.PubMedCrossRef
44.
Zurück zum Zitat Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323:1843–4.PubMedPubMedCentral Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323:1843–4.PubMedPubMedCentral
45.
46.
Zurück zum Zitat Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020;5:335–7.PubMedPubMedCentralCrossRef Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020;5:335–7.PubMedPubMedCentralCrossRef
Metadaten
Titel
Gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and meta-analysis
verfasst von
Sepideh Benvari
Shima Mahmoudi
Mohsen Mohammadi
Publikationsdatum
04.06.2022
Verlag
Springer Nature Singapore
Schlagwort
COVID-19
Erschienen in
World Journal of Pediatrics / Ausgabe 9/2022
Print ISSN: 1708-8569
Elektronische ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-022-00553-1

Neu im Fachgebiet Pädiatrie

Steigende Zahl von Skorbut-Fällen bei Kindern

Eine Erkrankung, die eigentlich der Vergangenheit angehören sollte, scheint in reichen westlichen Nationen wieder häufiger aufzutreten: Seit der Coronapandemie steigt bei Kindern und Jugendlichen in Frankreich die Inzidenz von Skorbut.

Vermeidung negativer Appendektomie und übersehener Appendizitis

Die Diagnose einer akuten Appendizitis stellt insbesondere im Kleinkindes- und Kindesalter eine Herausforderung dar. Ein israelisches Forschungsteam hat nun negative Appendektomien sowie zunächst übersehene Appendizitiden, die erst bei einem zweiten Besuch in der Notaufnahme diagnostiziert wurden, genauer untersucht.

Gespräche über Behandlungswünsche am Lebensende

Mit Jugendlichen und jungen Erwachsenen, die an einer Krebserkrankung sterben werden, finden Gespräche über ihre Wünsche für die Versorgung am Lebensende oft nur selten oder gar nicht statt. Die Autoren einer aktuellen US-amerikanische Studie mahnen, die Bedeutung solcher Gespräche nicht zu unterschätzen.

Hohe Atrophierate nach Hodentorsion im Kindesalter

Auf längere Sicht ist die Atrophierate nach einer Hodentorsion pädiatrischer Patienten erschreckend hoch. Das hat eine Studie mit jahrelanger Nachbeobachtung ergeben. Entscheidend ist die Zeit, die bis zur Detorsion verstreicht.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.