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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 9/2022

04.08.2022 | COVID-19 | Original Article

Genome-wide association study of SARS-CoV-2 infection in Chinese population

verfasst von: Jie Fan, Quan-Xin Long, Ji-Hua Ren, Hao Chen, Meng-Meng Li, Zheng Cheng, Juan Chen, Li Zhou, Ai-Long Huang

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2022

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Abstract

Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 × 10−6). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 × 10−5) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options.
Literatur
2.
Zurück zum Zitat Zu ZY, Jiang MD, Xu PP et al (2020) Coronavirus disease 2019 (COVID-19): a perspective from China. Radiology 296(2):E15–E25 CrossRef Zu ZY, Jiang MD, Xu PP et al (2020) Coronavirus disease 2019 (COVID-19): a perspective from China. Radiology 296(2):E15–E25 CrossRef
3.
Zurück zum Zitat Yu X, Yang R (2020) COVID-19 transmission through asymptomatic carriers is a challenge to containment. Influenza Other Respir Viruses 14(4):474–475 CrossRef Yu X, Yang R (2020) COVID-19 transmission through asymptomatic carriers is a challenge to containment. Influenza Other Respir Viruses 14(4):474–475 CrossRef
4.
Zurück zum Zitat Zhang Y, Yang H, Li S, Li WD, Wang J, Wang Y (2021) Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults. Mech Ageing Dev 194:111433 CrossRef Zhang Y, Yang H, Li S, Li WD, Wang J, Wang Y (2021) Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults. Mech Ageing Dev 194:111433 CrossRef
6.
Zurück zum Zitat Armstrong J, Rudkin JK, Allen N et al (2020) Dynamic linkage of COVID-19 test results between Public Health England’s Second Generation Surveillance System and UK Biobank. Microb Genom 6(7):mgen00937 Armstrong J, Rudkin JK, Allen N et al (2020) Dynamic linkage of COVID-19 test results between Public Health England’s Second Generation Surveillance System and UK Biobank. Microb Genom 6(7):mgen00937
7.
Zurück zum Zitat Grigorescu F, Lautier C (2020) How geneticists contribute to understanding of COVID-19 disease pathogenicity. Acta Endocrinol (Buchar) 16(3):346–352 CrossRef Grigorescu F, Lautier C (2020) How geneticists contribute to understanding of COVID-19 disease pathogenicity. Acta Endocrinol (Buchar) 16(3):346–352 CrossRef
8.
Zurück zum Zitat Clayton PT (2020) Is susceptibility to severe COVID-19 disease an inborn error of metabolism. J Inherit Metab Dis 43(5):906–907 CrossRef Clayton PT (2020) Is susceptibility to severe COVID-19 disease an inborn error of metabolism. J Inherit Metab Dis 43(5):906–907 CrossRef
9.
Zurück zum Zitat Kaser A (2020) Genetic risk of severe COVID-19. N Engl J Med 383(16):1590–1591 CrossRef Kaser A (2020) Genetic risk of severe COVID-19. N Engl J Med 383(16):1590–1591 CrossRef
10.
Zurück zum Zitat Ellinghaus D, Degenhardt F, Bujanda L et al (2020) Genomewide association study of severe COVID-19 with respiratory failure. N Engl J Med 383(16):1522–1534 CrossRef Ellinghaus D, Degenhardt F, Bujanda L et al (2020) Genomewide association study of severe COVID-19 with respiratory failure. N Engl J Med 383(16):1522–1534 CrossRef
11.
Zurück zum Zitat Ramlall V, Thangaraj PM, Meydan C et al (2020) Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Nat Med 26(10):1609–1615 CrossRef Ramlall V, Thangaraj PM, Meydan C et al (2020) Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Nat Med 26(10):1609–1615 CrossRef
12.
Zurück zum Zitat Saulle I, Vanetti C, Goglia S et al (2020) A new ERAP2/Iso3 isoform expression is triggered by different microbial stimuli in human cells. Could it play a role in the modulation of SARS-CoV-2 infection. Cells 9(9):1951 Saulle I, Vanetti C, Goglia S et al (2020) A new ERAP2/Iso3 isoform expression is triggered by different microbial stimuli in human cells. Could it play a role in the modulation of SARS-CoV-2 infection. Cells 9(9):1951
13.
Zurück zum Zitat Hu J, Li C, Wang S, Li T, Zhang H (2020) Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. medRxiv 15(1):10 Hu J, Li C, Wang S, Li T, Zhang H (2020) Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. medRxiv 15(1):10
14.
Zurück zum Zitat Long QX, Tang XJ, Shi QL et al (2020) Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med 26(8):1200–1204 CrossRef Long QX, Tang XJ, Shi QL et al (2020) Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med 26(8):1200–1204 CrossRef
15.
Zurück zum Zitat The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eur J Hum Genet (2020) 28(6):715–718 The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eur J Hum Genet (2020) 28(6):715–718
16.
Zurück zum Zitat Elhabyan A, Elyaacoub S, Sanad E, Abukhadra A, Elhabyan A, Dinu V (2020) The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: a systematic review. Virus Res 289:198163 CrossRef Elhabyan A, Elyaacoub S, Sanad E, Abukhadra A, Elhabyan A, Dinu V (2020) The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: a systematic review. Virus Res 289:198163 CrossRef
17.
Zurück zum Zitat Nelson CP, Sama IE, Codd V et al (2020) Genetic associations with plasma angiotensin converting enzyme 2 concentration: potential relevance to COVID-19 risk. Circulation 142(11):1117–1119 CrossRef Nelson CP, Sama IE, Codd V et al (2020) Genetic associations with plasma angiotensin converting enzyme 2 concentration: potential relevance to COVID-19 risk. Circulation 142(11):1117–1119 CrossRef
18.
Zurück zum Zitat Smatti MK, Al-Sarraj YA, Albagha O, Yassine HM (2020) Host genetic variants potentially associated with SARS-CoV-2: a multi-population analysis. Front Genet 11:578523 CrossRef Smatti MK, Al-Sarraj YA, Albagha O, Yassine HM (2020) Host genetic variants potentially associated with SARS-CoV-2: a multi-population analysis. Front Genet 11:578523 CrossRef
19.
Zurück zum Zitat Wallentin L, Lindbäck J, Eriksson N et al (2020) Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J 41(41):4037–4046 CrossRef Wallentin L, Lindbäck J, Eriksson N et al (2020) Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J 41(41):4037–4046 CrossRef
20.
Zurück zum Zitat Wang F, Huang S, Gao R et al (2020) Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. Cell Discov 6(1):83 CrossRef Wang F, Huang S, Gao R et al (2020) Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. Cell Discov 6(1):83 CrossRef
21.
Zurück zum Zitat Zeberg H, Pääbo S (2020) The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature 587(7835):610–612 CrossRef Zeberg H, Pääbo S (2020) The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature 587(7835):610–612 CrossRef
22.
Zurück zum Zitat Beyerstedt S, Casaro EB, Rangel ÉB (2021) COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis 40(5):905–919 CrossRef Beyerstedt S, Casaro EB, Rangel ÉB (2021) COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis 40(5):905–919 CrossRef
23.
Zurück zum Zitat D’Amico S, Tempora P, Lucarini V et al (2021) ERAP1 and ERAP2 enzymes: a protective shield for RAS against COVID-19. Int J Mol Sci 22(4):1705 D’Amico S, Tempora P, Lucarini V et al (2021) ERAP1 and ERAP2 enzymes: a protective shield for RAS against COVID-19. Int J Mol Sci 22(4):1705
24.
Zurück zum Zitat López de Castro JA (2018) How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins. Front Immunol 9:2463 CrossRef López de Castro JA (2018) How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins. Front Immunol 9:2463 CrossRef
25.
Zurück zum Zitat Admon A (2019) ERAP1 shapes just part of the immunopeptidome. Hum Immunol 80(5):296–301 CrossRef Admon A (2019) ERAP1 shapes just part of the immunopeptidome. Hum Immunol 80(5):296–301 CrossRef
26.
Zurück zum Zitat Pepelyayeva Y, Amalfitano A (2019) The role of ERAP1 in autoinflammation and autoimmunity. Hum Immunol 80(5):302–309 CrossRef Pepelyayeva Y, Amalfitano A (2019) The role of ERAP1 in autoinflammation and autoimmunity. Hum Immunol 80(5):302–309 CrossRef
27.
Zurück zum Zitat Reeves E, James E (2018) The role of polymorphic ERAP1 in autoinflammatory disease. Biosci Rep 38(4):BSR20171503 Reeves E, James E (2018) The role of polymorphic ERAP1 in autoinflammatory disease. Biosci Rep 38(4):BSR20171503
28.
Zurück zum Zitat Shelton JF, Shastri AJ, Ye C et al (2021) Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity. Nat Genet 53(6):801–808 CrossRef Shelton JF, Shastri AJ, Ye C et al (2021) Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity. Nat Genet 53(6):801–808 CrossRef
29.
Zurück zum Zitat Mapping the human genetic architecture of COVID-19.  Nature  (2021) 600(7889):472–477 Mapping the human genetic architecture of COVID-19.  Nature  (2021) 600(7889):472–477
Metadaten
Titel
Genome-wide association study of SARS-CoV-2 infection in Chinese population
verfasst von
Jie Fan
Quan-Xin Long
Ji-Hua Ren
Hao Chen
Meng-Meng Li
Zheng Cheng
Juan Chen
Li Zhou
Ai-Long Huang
Publikationsdatum
04.08.2022
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-022-04478-5