Skip to main content
main-content

26.06.2020 | COVID-19 | Research article | Ausgabe 1/2020 Open Access

BMC Medicine 1/2020

COVID-19: a retrospective cohort study with focus on the over-80s and hospital-onset disease

Zeitschrift:
BMC Medicine > Ausgabe 1/2020
Autoren:
Simon E. Brill, Hannah C. Jarvis, Ezgi Ozcan, Thomas L. P. Burns, Rabia A. Warraich, Lisa J. Amani, Amina Jaffer, Stephanie Paget, Anand Sivaramakrishnan, Dean D. Creer
Wichtige Hinweise

Supplementary information

Supplementary information accompanies this paper at https://​doi.​org/​10.​1186/​s12916-020-01665-z.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Background

Data from the UK COVID-19 outbreak are emerging, and there are ongoing concerns about a disproportionate effect on ethnic minorities. There is very limited information on COVID-19 in the over-80s, and the rates of hospital-onset infections are unknown.

Methods

This was a retrospective cohort study from electronic case records of the first 450 patients admitted to our hospital with PCR-confirmed COVID-19, 77% of the total inpatient caseload to date. Demographic, clinical and biochemical data were extracted. The primary endpoint was death during the index hospital admission. The characteristics of all patients, those over 80 years of age and those with hospital-onset COVID-19 were examined.

Results

The median (IQR) age was 72 (56, 83), with 150 (33%) over 80 years old and 60% male. Presenting clinical and biochemical features were consistent with those reported elsewhere. The ethnic breakdown of patients admitted was similar to that of our underlying local population. Inpatient mortality was high at 38%.
Patients over 80 presented earlier in their disease course and were significantly less likely to present with the typical features of cough, breathlessness and fever. Cardiac co-morbidity and markers of cardiac dysfunction were more common, but not those of bacterial infection. Mortality was significantly higher in this group (60% vs 28%, p < 0.001). Thirty-one (7%) patients acquired COVID-19 having continuously been in hospital for a median of 20 (14, 36) days. The peak of hospital-onset infections occurred at the same time as the overall peak of admitted infections. Despite being older and more frail than those with community-onset infection, their outcomes were no worse.

Conclusions

Inpatient mortality was high, especially among the over-80s, who are more likely to present atypically. The ethnic composition of our caseload was similar to the underlying population. While a significant number of patients acquired COVID-19 while already in hospital, their outcomes were no worse.
Zusatzmaterial
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2020

BMC Medicine 1/2020 Zur Ausgabe

Webinare und Artikel zur Corona-Krise

Die aktuelle Entwicklung zu SARS-CoV-2 (2019-nCoV) und der Lungenkrankheit COVID-19 im Überblick. » zum Dossier

Passend zum Thema

ANZEIGE

Was hat ein Nobelpreis mit Demenz zu tun?

In Deutschland leiden rund 1,7 Millionen Menschen an Demenz, davon zwei Drittel aufgrund von Morbus Alzheimer. Im Jahr 2050 werden es geschätzt schon drei Millionen sein. Doch sind Demenzerkrankungen bisher nicht heilbar und die erhofften Erfolge mit Anti-Amyloid-Wirkstoffen in der Therapie von Alzheimer-Demenz blieben bislang aus.

ANZEIGE

Fasten gegen das Vergessen? Das große Potential der Autophagie

Autophagie – der neue Hoffnungsträger im Kampf gegen altersbedingte Erkrankungen. Spätestens seit der Verleihung des Nobelpreises für Medizin im Jahr 2016 rückt der körpereigene Selbstreinigungsmechanismus immer stärker in den Fokus von Wissenschaftlern und Medizinern.

ANZEIGE

consilium Geriatrie – Expertenwissen zum Thema gesundes Altern und Demenzprävention

Körperliche und geistige Gesundheit bis ins hohe Alter. Kaum ein Wunsch ist in der Gesellschaft so präsent. Umso wichtiger ist es über die verschiedenen altersbedingten Krankheiten und deren Prävention informiert zu sein. Das consilium Geriatrie ist Ihr persönlicher Zugang zu Expertenwissen zum Thema altersbedingte Erkrankungen und Demenzprävention.

Bildnachweise